A5063586869- Water Treatment and Disinfection
- Carcinogens and Genotoxicity Assessment
- Computational Drug Discovery Methods
- Sulfur Compounds in Biology
- Immunotoxicology and immune responses
- Intelligent Tutoring Systems and Adaptive Learning
- Pharmaceutical and Antibiotic Environmental Impacts
- Antenna Design and Analysis
- Health, Environment, Cognitive Aging
- Mine drainage and remediation techniques
- Restraint-Related Deaths
- Antenna Design and Optimization
- Animal testing and alternatives
- Statistical Methods in Clinical Trials
- Groundwater flow and contamination studies
- Metabolomics and Mass Spectrometry Studies
- Organizational Management and Leadership
- Teaching and Learning Programming
- Animal Ecology and Behavior Studies
- Chemistry and Chemical Engineering
- Environmental Toxicology and Ecotoxicology
- Atmospheric chemistry and aerosols
- Network Time Synchronization Technologies
- Distributed systems and fault tolerance
- Topic Modeling
Canary Wharf Group (United Kingdom)
2024
Stratophase (United Kingdom)
2021
California Institute of Technology
2003
Welsh Local Government Association
1995
University of Warwick Science Park
1989
The results of the US Environmental Protection Agency, Office Drinking Water, sampling and analysis volatile organic compounds (VOCs) in finished water supplies that use groundwater sources are discussed. Concentrations 29 VOCs addition to five trihalomethanes total carbon from 945 were measured. most frequently found other than trichloroethylene, 1,1,1‐trichloroethane, tetrachloroethylene, cis‐ and/or trans‐1,2‐dichloroethylene, 1,1‐dichloroethane. Approximately half samples taken a random...
The discovery of carcinogenic nitrosamine impurities above the safe limits in pharmaceuticals has led to an urgent need develop methods for extending structure–activity relationship (SAR) analyses from relatively limited datasets, while level confidence required that SAR indicates there is significant value investigating effect individual substructural features a statistically robust manner. This challenging exercise perform on small dataset, since practice, compounds contain mixture...
Low levels of N-nitrosamines (NAs) were detected in pharmaceuticals and, as a result, health authorities (HAs) have published acceptable intakes (AIs) to limit potential carcinogenic risk. The rationales behind the AIs not been provided understand process for selecting TD50 or read-across analog. In this manuscript we evaluated toxicity data eleven common NAs comprehensive and transparent consistent with ICH M7. This evaluation included substances which had datasets that robust, limited but...
Under ICH M7, impurities are assessed using the bacterial reverse mutation assay (i.e., Ames test) when predicted positive in silico methodologies followed by expert review. N-Nitrosamines (NAs) have been of recent concern as pharmaceuticals, mainly because their potential to be highly potent mutagenic carcinogens rodent bioassays. The purpose this analysis was determine sensitivity predict carcinogenic outcome with curated proprietary Vitic (n = 131) and Leadscope 70) databases. NAs were...
The tumorigenic dose 50 (TD
N-nitrosamines (NAs) are a class of compounds which many, especially the small dialkyl type, indirect acting DNA alkylating mutagens. Their presence in pharmaceuticals is subject to very strict acceptable daily intake (AI) limits, traditionally expressed on mass basis. Here we demonstrate that AIs not experimentally derived for specific compound, but via statistical extrapolation or read across suitable analog, should be molar scale corrected target substance's molecular weight. This would...
Virtual Control Groups (VCGs) based on Historical Data (HCD) in preclinical toxicity testing have the potential to reduce animal usage. As a case study we retrospectively analyzed impact of replacing Concurrent (CCGs) with VCGs treatment-relatedness 28 selected histopathological findings reported either rat or dog eTOX database. We developed novel methodology whereby statistical predictions using CCGs varying covariate similarity were compared designations from original toxicologist reports;...
The unexpected finding of N-nitrosamine (NA) impurities in many pharmaceutical products raised significant challenges for industry and regulators. In addition to well-studied small molecular weight NAs, which are potent rodent carcinogens, novel NAs associated with active ingredients have been found, limited or no safety data. A tiered approach establishing Acceptable Intake (AI) limits NA has established using chemical-specific data, read-across, a class-specific TTC limit. There ∼140 some...
Large data sharing projects amongst the pharmaceutical industry have potential to generate new insights using on a scale that has not been previously available. A retrospective analysis of preclinical toxicology collected as part eTOX project was conducted with aim provide background rates and treatment-related value both clinical pathology histopathology datasets. Incorporated into this an extensive consolidation task standardise all data. Reference intervals for common parameters in rat...
Preclinical inter-species concordance can increase the predictivity of observations to clinic, potentially reducing drug attrition caused by unforeseen adverse events. We quantified histopathological findings and target organ toxicities across four preclinical species in eTOX database using likelihood ratios (LRs). This was done whilst only comparing between studies with similar compound exposure (Δ|Cmax| ≤ 1 log-unit), repeat-dosing duration, animals same sex. discovered 24 previously...
Abstract Abandoned mines create pollution problems in rivers as minewater levels rise and discharges of metal‐rich acidic waters occur. Mines adjacent to can cause serious problems, reducing fish stocks preventing restocking. A computer model has been used simulate the impact these devise an optimal treatment strategy meet river quality objectives. The use this model, through application two case studies, is described.
The transition from rule-based to neural-based architectures has made it more difficult for low-resource languages like Scottish Gaelic participate in modern language technologies.The performance of deep-learning approaches correlates with the availability training data, and have limited data reserves by definition.Historical non-standard orthographic texts could be used supplement but manual conversion these is expensive timeconsuming.This paper describes development a neuralbased...
<h3>To the Editor.</h3> —In October 1983Archives, Cartwright et al<sup>1</sup>describe a patient who inhaled butane gas. As noted in article, most hydrocarbon incidents have been associated with aspiration of aliphatic hydrocarbons higher molecular weight (C<sub>8</sub>and above). Butane, however, is low (C<sub>4</sub>) gaseous that has designated as simple asphyxiant,<sup>2,3</sup>since no systemic effect had linked to its inhalation.<sup>3</sup>The dosage far exceeds an industrial...