A5053890725- RNA and protein synthesis mechanisms
- Machine Learning in Bioinformatics
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Bacterial Genetics and Biotechnology
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- RNA Research and Splicing
- Protein Structure and Dynamics
Friedrich Schiller University Jena
2022-2024
Hochschule Mittweida
2017-2020
Abstract Storage and directed transfer of information is the key requirement for development life. Yet any stored on our genes useless without its correct interpretation. The genetic code defines rule set to decode this information. Aminoacyl-tRNA synthetases are at heart process. We extensively characterize how these enzymes distinguish all natural amino acids based computational analysis crystallographic structure data. results meta-analysis show that read-out a delicate interplay between...
The origin of the machinery that realizes protein biosynthesis in all organisms is still unclear. One key component this are aminoacyl tRNA synthetases (aaRS), which ligate tRNAs to amino acids while consuming ATP. Sequence analyses revealed these enzymes can be divided into two complementary classes. Both classes differ significantly on a sequence and structural level, feature different reaction mechanisms, occur diverse oligomerization states. one unifying aspect both their function...
The International Virus Bioinformatics Meeting 2022 took place online, on 23-25 March 2022, and has attracted about 380 participants from all over the world. goal of meeting was to provide a meaningful interactive scientific environment promote discussion collaboration inspire suggest new research directions questions. created highly even without physical face-to-face interactions. This is focal point gain an insight into state-of-the-art virus bioinformatics landscape interact with...
The 2023 International Virus Bioinformatics Meeting was held in Valencia, Spain, from 24–26 May 2023, attracting approximately 180 participants worldwide. primary objective of the conference to establish a dynamic scientific environment conducive discussion, collaboration, and generation novel research ideas. As first in-person event following SARS-CoV-2 pandemic, meeting facilitated highly interactive exchanges among attendees. It served as pivotal gathering for gaining insights into...
ABSTRACT Storage and directed transfer of information is the key requirement for development life. Yet any stored on our genes useless without its correct interpretation. The genetic code defines rule set to decode this information. Aminoacyl-tRNA synthetases are at heart process. For first time, we extensively characterize how these enzymes distinguish all natural amino acids based computational analysis crystallographic structure data. results meta-analysis show that read-out a delicate...
Abstract RNA-protein interactions (RPIs) are crucial for accurately operating various processes in and between organisms across kingdoms of life. Mutual detection RPI partner molecules depends on distinct sequential, structural, or thermodynamic features, which can be determined via experimental bioinformatic methods. Still, the underlying molecular mechanisms many RPIs poorly understood. It is further hypothesized that not even described yet. Computational prediction continuously challenged...
Abstract The origin of the machinery that realizes protein biosynthesis in all organisms is still unclear. One key component this are aminoacyl tRNA synthetases (aaRS), which ligate tRNAs to amino acids while consuming ATP. Sequence analyses revealed these enzymes can be divided into two complementary classes. Both classes differ significantly on a sequence and structural level, feature different reaction mechanisms, occur diverse oligomerization states. one unifying aspect both their...