A5010356691- Osteoarthritis Treatment and Mechanisms
- Spine and Intervertebral Disc Pathology
- Knee injuries and reconstruction techniques
- Lower Extremity Biomechanics and Pathologies
- Elasticity and Material Modeling
- Proteoglycans and glycosaminoglycans research
- Total Knee Arthroplasty Outcomes
- Tendon Structure and Treatment
- Bacterial biofilms and quorum sensing
- Musculoskeletal pain and rehabilitation
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Advanced Chemical Sensor Technologies
- Botulinum Toxin and Related Neurological Disorders
- Plant and Biological Electrophysiology Studies
- Primate Behavior and Ecology
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Scoliosis diagnosis and treatment
- Balance, Gait, and Falls Prevention
- Coronary Interventions and Diagnostics
- Veterinary Equine Medical Research
- Body Composition Measurement Techniques
- Physical Activity and Health
- Arctic and Antarctic ice dynamics
Korea Institute of Industrial Technology
2015-2023
Alberta Innovates
2021
University of Maryland, College Park
2013-2016
University of Calgary
2004-2012
The defining characteristic of the annulus fibrosus (AF) intervertebral disc (IVD) has long been lamellar structures that consist highly ordered collagen fibers arranged in alternating oblique angles from one layer to next. However, a series recent histologic studies have demonstrated AF lamellae contain elastin- and type VI collagen-rich secondary "cross-bridge" across lamellae. In this study, we use optical coherence tomography (OCT) elucidate three-dimensional (3-D) morphologies these...
The aim of this study was to investigate if the experimentally detected altered chondrocyte volumetric behavior in early osteoarthritis can be explained by changes extracellular and pericellular matrix properties cartilage. Based on our own experimental tests literature, structural mechanical parameters for normal osteoarthritic cartilage were implemented into a multiscale fibril-reinforced poroelastic swelling model. Model simulations compared with observed cell volume mechanically loaded...
Sarcopenia is a symptom in which muscle mass decreases due to decreasing the number of fibers and cross-sectional area as aging. This study aimed develop machine learning classification model for predicting sarcopenia through inertial measurement unit (IMU)-based physical performance data female elderly.Seventy-eight subjects from an elderly population (aged: 78.8±5.7 years) volunteered participate this study. To evaluate elderly, experiment conducted timed-up-and-go test (TUG) 6-minute walk...
A combinatorial biofilm treatment involving a low dose of antibiotics along with small amount electricity is known as the bioelectric effect (BE). When an external electric field or current applied, biofilms can be affected by resulting electrostatic force. Our group researching maximization force through integration both alternating and direct currents, voltage below electrolysis threshold (0.82 V). To validate efficacy this technology, in present work we investigated two major...
Interlamellar shear may play an important role in the homeostasis and degeneration of intervertebral disk. Accurately modeling behavior interlamellar compartment would enhance study its mechanobiology. In this study, physical experiments were utilized to describe define a constitutive model, which was implemented into finite element analysis. Ovine annulus fibrosus (AF) specimens from three locations within disk (lateral, outer anterior, inner anterior) subjected vitro mechanical testing....
Basic science study using in vitro tissue testing and imaging to characterize local strains annulus fibrosus (AF) tissue.To mesoscale strain inhomogeneities between lamellar inter-/translamellar (ITL) matrix compartments during shear loading.The intervertebral disc is characterized by significant heterogeneities structure plays a critical role load distribution force transmission the spine. In particular, AF possesses architecture interdigitated complex network of extracellular components...
Experimental study.In this study, the ambient temperature of a radiofrequency (RF) electrode tip was compared and analyzed in terms products, mode, flow quantity, rate.Endoscopic spine surgery is widely used operation for degenerative lumbar stenosis herniated disc. To perform endoscopic surgery, dedicated instruments like RF generator are essential.An evaluation system capable measuring under equal conditions at certain distance from manufactured. The between sensor set to 1, 5, 10 mm....
Bioelectric effect is known as combinatorial biofilm treatment with low dose of antibiotics small electricity. When external electric field or current are applied, biofilms can be affected by the electrostatic force, non-uniform distribution essential electrolytes, induction activity enzyme, and increase permeability biofilms. In this work, we have focused on reduction applied power consumption that could avoid water electrolysis which was one major challenges for biomedical applications. We...
A compromised stability in the elderly population is considered a major factor for fall risk assessment. The dynamic of human gait with various mathematical metrics has been extensively studied to find prediction index and prevention strategies that can be embedded wearable monitoring sensor. In this study, zero-moment point method (ZMP) was utilized analyzing young female populations. Participants groups no musculoskeletal disorders experience were asked walk at habitual speed on 10 m flat...
To estimate the accuracy of quantitative computed tomography (QCT) as a method to measure bone mineral density (BMD) in vicinity titanium prosthesis, we investigated effects (1) (2) offset longitudinal axis be examined from that gantry CT scanner, (3) size field view (FOV) and (4) combination these on based measurements cortical cancellous specimens. 14 bovine parallelepipeds were used this investigation. The specimens scanned with without when centered scanner at distance cm. Image data...
Biofilms comprise diverse bacteria and fungi with slime material, especially in humid conditions. The surface of the heat ventilation air conditioning (HVAC) system, at evaporator, is high moisture conditions due to compression relaxation refrigerant. electrically polarized molecules, which include polysaccharide, DNA, liposome, amino acids. Thus, when an electric field applied biofilms, creates electrostatic force that enhances destruction biofilms results detachment from surface....
Basic science, experimental animal study.To determine the effects of Botulinum toxin type A (BTX-A) injections on mechanical properties skinned muscle fibers (cells) rabbit paraspinal muscles.BTX-A has been widely used in treatment disorders hyperactivity, such as spasticity, dystonia, and back pain. However, BTX-A injection shown to cause atrophy, fat infiltration, decreased force output target muscles, but its potential contractile machinery production cellular level remain...
By virtue of their upright locomotion, similar to that humans, motion analysis non-human primates has been widely used in order better understand musculoskeletal biomechanics and neuroscience problems. Given the difficulty conducting a marker-based infrared optical tracking system for behavior primates, 2-dimensional (D) video applied. Distinct from conventional system, depth image sensor provides 3-D information on movement without any skin markers. The specific aim this study was develop...
Osteoporosis induced bone fracture is not limited to simple damage according its fractured region and the age of damaged person. Therefore, there has been more necessity understand study biomechanical aspects osteoporosis, relevant research actively conducted. With development medical imaging technology, reconstruction CT images into a 3D model made possible, it conducted analyze 3-dimensionally inhomogeneously distributed mineral density values. The strength computational analysis based on...