A5078834725- Lipid metabolism and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Micro and Nano Robotics
- Nanopore and Nanochannel Transport Studies
- Advanced Fluorescence Microscopy Techniques
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Bio-sensing Technologies
- Advanced Biosensing Techniques and Applications
Tallinn University of Technology
2023-2025
University of Kurdistan
2020
Molecular movement and interactions at the single-molecule level, particularly in live cells, are often studied using fluorescence correlation spectroscopy (FCS). While powerful, FCS has notable drawbacks: It requires high laser intensities long acquisition times, increasing phototoxicity, relies on problematic statistical assumptions data fitting. We introduce intensity trace analysis (FITSA), a Bayesian method that directly analyzes traces. FITSA offers faster, more stable convergence than...
Lipoprotein lipase (LPL), a crucial enzyme in the intravascular hydrolysis of triglyceride-rich lipoproteins, is potential drug target for treatment hypertriglyceridemia. The activity and stability LPL are influenced by complex ligand network. Previous studies performed dilute solutions suggest that can appear various oligomeric states. However, it was not known how physiological environment, blood plasma, affects action LPL. In current study, we demonstrate albumin, major protein component...
By applying entropic barriers, we present a rod separation mechanism that induces the movement of rods different sizes in opposite directions. This is based on combination saw-tooth channel, static force, and an oscillating driving force. The asymmetric shape channel elongated causesa complicated interaction effect between walls which reduces accessible configuration space for leads to free-energy effects.