The accuracy of empirical force fields is critical for meaningful molecular dynamics simulations concentrated ionic solutions. Current models are typically developed on the basis single ion properties such as monohydrate energy in gas phase, or absolute hydration free at infinite dilution. However, failure these to represent accurately solutions cannot be excluded. Here, issues illustrated a polarizable potential based classical Drude oscillators. To model solutions, parameters functions...

In a complex and dynamic job shop containing logistics factor, schedule needs to be generated rapidly, so the real-time scheduling method is more suitable for such scenario. Such takes advantage of local information within short time due rapid changes under uncertain environment. Therefore, how make use future by prediction while ensuring robustness valuable problem. To solve it, firstly, new model algorithm proposed. There kind release moment task which can give AGVs longest prepare than...

As communication technology and smart manufacturing have developed, the industrial internet of things (IIoT) has gained considerable attention from academia industry. Wireless sensor networks (WSNs) many advantages with broad applications in areas including environmental monitoring, which makes it a very important part IIoT. However, energy depletion hardware malfunctions can lead to node failures WSNs. The environment also impact wireless channel transmission, leading network reliability...

Mechanosensitive PIEZO channels are thought to open their pore through tension-induced flattening of large transmembrane arm domains. Yet, the structural basis this activation remains unclear. Here, we uncover conformational coupling between and opening in PIEZO2 by capturing protein motions across length scales using hybrid-resolution molecular dynamics simulations. Sampling multiple microsecond-long trajectories under physiological tension show that correlates with anticlockwise rotation...

In a smart factory environment, much larger amount of data are transmitted in the workshop networks bringing big challenges to transfer capability and energy usage efficiency. workshop, two main networks, i.e., wired/wireless fieldbus wireless sensor usually used collect transmit separately; thus, this paper proposes mobile hierarchical transmission architecture integrate these also taking advantages from existing intelligence factories, such as automatic guided vehicles (AGVs), implement...

In a smart factory environment, much larger amount of data is transmitted in the workshop networks bringing big challenges to transfer capability and energy usage efficiency. workshop, two main (i.e., wired/wireless fieldbus wireless sensor networks) are usually used collect transmit separately; thus, this work proposes integrate these by also taking advantage existing mobile intelligences factories, such as automatic guided vehicles, implement novel materials delivery scheme well suited for...

High quantity of slurries, kerf, are generated during ingot wafering and represent up to 40% the silicon in weight. The highly pure contained kerf is contaminated with organics, metal impurities, water an oxide layer. recovery could be efficient way reduce costs production solar panels through material energy savings. At high temperatures, organic contamination causes formation carbide species that difficult segregate remelting into a ingot. Also, fusion silicon, temperatures 1500°C reached...

In the context of new retail and personalized, small-batch, distributed collaborative production, orders arrive in real time, each workshop needs to organize production lines based on suborders time under constraints smart contracts. However, existing cloud centralized scheduling method has very high calculation communication costs when inserting fully reactive edge is difficult meet various order-level requirements customers. Therefore, this article proposes a real-time model that considers...

In recent years, the individualized demand of customers brings small batches and diversification orders towards enterprises. The application enabling technologies in factory, such as industrial Internet things (IIoT) cloud manufacturing (CMfg), enhances ability customer requirement automatic elicitation process control. job shop scheduling problem with a random arrival time dramatically increases difficulty management. Thus, how to collaboratively schedule production logistics resources...

Abnormal alteration of bone morphogenetic protein (BMP) signaling is implicated in many types diseases including cancer and heterotopic ossifications. Hence, small molecules targeting BMP type I receptors (BMPRI) to interrupt are believed be an effective approach treat these diseases. However, lack understanding the molecular determinants responsible for binding selectivity current inhibitors has been a big hindrance development clinical use. To address this issue, we carried out silico...

The development of industrial-enabling technology, such as the industrial Internet Things and physical network system, makes it possible to use real-time information in production-logistics scheduling. Real-time an intelligent factory is random, arrival customers’ jobs, fuzzy, processing time Production-Logistics Resources. Besides, coordination production logistic resources a flexible workshop also hot issue. availability this will enhance quality making scheduling decisions. However, when...

Activins transduce the TGF-β pathway through a heteromeric signaling complex consisting of type I and II receptors, activins also inhibit bone morphogenetic protein (BMP) mediated by receptor ALK2. Recent studies indicated that activin A cross-activates BMP ALK2R206H, mutation associated with Fibrodysplasia Ossificans Progressiva (FOP). How inhibits ALK2WT-mediated but activates ALK2R206H-mediated is not well understood, here we offer some insights into its molecular mechanism. We first...

Various all-atom molecular dynamics (MD) simulation methods have been developed to compute free energies and crossing rates of ions small molecules through ion channels. However, a systemic comparison across different is scarce. Using carbon nanotube as model conductance channel, we computed the single-channel permeability for potassium using umbrella sampling, Markovian milestoning, steady-state flux under applied voltage. We show that slightly modified inhomogeneous solubility-diffusion...

In recent years, the individualized demand of customers brings small batches and diversification orders towards enterprises. The application enabling technologies in factory, such as Industrial Internet Things (IIoT) Cloud Manufacturing (CMfg), enhances ability customer requirement automatic elicitation manufacturing process control. job shop scheduling problem with random arrival time dramatically increases difficulty management. Thus, how to collaboratively schedule production logistics...

The widespread deployment of smart phone and object technologies have fostered the rise People-centric Internet Things. Things is direct motivation drive for agile social manufacturing applications in future Industry 4.0. However, it challenging human to organize services around with crowdsourced, open, decentralized objects. In this paper, we propose a service-oriented architecture Industrial Things, define reference middleware both addition, activities component physical are presented...

Dynamically tuned gyroscope (DTG) is used more and wildly in inertial navigator, so it significant to eliminate the gyro random drift noise order increase precise of DTG. The DTG error characteristics mathematic model were presented, a fast algorithm based on translation invariant discrete wavelet transform (TIDWT) was with new thresholding function, signal sampled dynamic disturbance are processed by this method, validity verified through experiment.

The tyrosine kinase inhibitors (TKIs) have improved overall survival of CML (chronic myeloid leukemia) patients and allow them to experience normal life expectancy. However, relapse drug resistance remain the main challenges in clinical treatment CML. B-cell lymphoma 6 (BCL6) is essential regulation multiple function such as immune response lymphomagenesis lymph node germinal cells. Recent studies shown that BCL6 required for maintenance leukemia stem cells CML, but expression Bcl-6 Imatinib...