A5019698804- Immune responses and vaccinations
- Immune cells in cancer
- Immune Response and Inflammation
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Inflammation biomarkers and pathways
- Reproductive System and Pregnancy
- Phagocytosis and Immune Regulation
- Zoonotic diseases and public health
- Stress Responses and Cortisol
- Respiratory Support and Mechanisms
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Medical and Biological Ozone Research
- Child Nutrition and Water Access
- Adipose Tissue and Metabolism
- IL-33, ST2, and ILC Pathways
- Neuroendocrine regulation and behavior
- Long-Term Effects of COVID-19
- Signaling Pathways in Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
McGill University Health Centre
2021-2025
McGill University
2024
Christie (Canada)
2024
University of Nottingham
1989
Since the vast majority of species solely rely on innate immunity for host defense, it stands to reason that a critical evolutionary trait like immunological memory evolved in this primitive branch our immune system. There is ample evidence vaccines such as bacillus Calmette-Guérin (BCG) induce protective responses (trained immunity) against heterologous pathogens. Here we show while BCG vaccination significantly reduces morbidity and mortality influenza A virus (IAV), fails provide...
Resident-tissue macrophages (RTMs) arise from embryonic precursors1,2, yet the developmental signals that shape their longevity remain largely unknown. Here we demonstrate in mice genetically deficient 12-lipoxygenase and 15-lipoxygenase (Alox15-/- mice) neonatal neutrophil-derived 12-HETE is required for self-renewal maintenance of alveolar (AMs) during lung development. Although seeding differentiation AM progenitors remained intact, absence led to a significant reduction AMs adult lungs...
Viral infections can cause acute respiratory distress syndrome (ARDS), systemic inflammation, and secondary cardiovascular complications. Lung macrophage subsets change during ARDS, but the role of heart macrophages in cardiac injury viral ARDS remains unknown. Here we investigate how immune signals typical for affect subsets, health, inflammation.
Disease tolerance is an evolutionarily conserved host defense strategy that preserves tissue integrity and physiology without affecting pathogen load. Unlike resistance, the mechanisms underlying disease remain poorly understood. In present study, we investigated whether adjuvant (β-glucan) can reprogram innate immunity to provide protection against influenza A virus (IAV) infection. β-Glucan treatment reduces morbidity mortality IAV infection, independent of resistance. The enhanced...
Alveolar macrophages (AMs) reside in the lower airways and play a crucial role lung health response to sterile inflammation infections. AMs possess remarkable adaptability different environmental challenges that can persist through their memory capacity (trained immunity). β-glucan has been characterized as potent inducer of central trained immunity by reprogramming hematopoietic stem cells (HSCs) bone marrow. In present study, we show systemic administration induces peripheral alveolar...
Pregnancy is associated with profound changes in immunity. However, pregnancy-related respiratory immune adaptations response to influenza infection and their impact on disease severity remain unclear. Here, we describe, a preclinical model of mid-gestation pregnancy, mechanism enhanced host defense against A virus (IAV) localized the nasal cavity that limits viral replication reduces magnitude intrapulmonary responses. Consequently, pregnant mice show reduced pulmonary pathology preserved...
Alveolar macrophages (AMs) reside in the lower airways and play a crucial role lung health response to sterile inflammation infections. AMs possess remarkable adaptability different environmental challenges that can persist through their memory capacity (trained immunity). β-glucan has been characterized as potent inducer of trained immunity by reprogramming hematopoietic stem cells (HSCs) bone marrow generating innate with enhanced responsiveness. In present study, we show systemic...
ABSTRACT Alveolar macrophages (AMs) reside in the lower airways and play a crucial role lung health response to sterile inflammation infections. AMs possess remarkable adaptability different environmental challenges that can persist through their memory capacity (trained immunity). β-glucan has been characterized as potent inducer of trained immunity by reprogramming hematopoietic stem cells (HSCs) bone marrow generating innate with enhanced responsiveness. In present study, we show systemic...
Alveolar macrophages (AMs) reside in the lower airways and play a crucial role lung health response to sterile inflammation infections. AMs possess remarkable adaptability different environmental challenges that can persist through their memory capacity (trained immunity). β-glucan has been characterized as potent inducer of trained immunity by reprogramming hematopoietic stem cells (HSCs) bone marrow generating innate with enhanced responsiveness. In present study, we show systemic...
<b>Introduction:</b> Acute respiratory distress syndrome is responsible for 400,000 deaths per year worldwide. Despite five decades of research, no immunomodulatory treatment has been proven to be effective. Trained immunity (TI) the ability innate immune system reprogrammed by a first insult, without persistent inflammation, then providing an increased response second insult. The aim this study confirm that TI could protect from acute lung injury (ALI). <b>Methods:</b> twelve weeks old...
Despite the worldwide application of vaccination and other antiviral interventions, pulmonary viral infections remain a persistent threat to human health. The 1918 influenza pandemic killed more than 40 million people in just one year, SARS-CoV-2 has 6.9 since 2019. While current approved COVID-19 vaccines are administered parenterally induce systemic immunity, they only prevent progression severe disease. Thus, vaccine platforms still needed for completely preventing disease subsequent...
ABSTRACT Immunity to infectious disease involves a combination of host resistance, which eliminates the pathogen, and tolerance, limits tissue damage. While severity most pulmonary viral infections, including influenza A virus (IAV), is linked excessive inflammation, our mechanistic understanding this observation remains largely unknown. Here we show that mitochondrial cyclophilin D (CypD) protects against IAV infection via tolerance. Mice deficient in CypD ( -/- mice) are significantly more...