A5022552248- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Cancer Diagnosis and Treatment
- Multisensory perception and integration
- Ear and Head Tumors
- Hearing Impairment and Communication
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Thyroid Cancer Diagnosis and Treatment
- Neuroscience and Music Perception
- Head and Neck Surgical Oncology
- Vasculitis and related conditions
- Oral and Maxillofacial Pathology
- Congenital heart defects research
- Cerebral Venous Sinus Thrombosis
- Head and Neck Anomalies
- Streptococcal Infections and Treatments
- Ophthalmology and Eye Disorders
- Tactile and Sensory Interactions
- Noise Effects and Management
Kobe City Medical Center General Hospital
2012-2025
Foundation for Biomedical Research and Innovation
2012-2025
Kyoto University
2014-2025
Shonan Oiso Hospital
2019-2025
Center for Clinical Research (United States)
2021-2024
Osaka Red Cross Hospital
2019-2024
Hospital for Sick Children
2017-2019
Osaka Hospital
2018-2019
SickKids Foundation
2017
Aizawa Hospital
2016
ABSTRACT From early stages of development, Sox2-class transcription factors (Sox1, Sox2 and Sox3) are expressed in neural tissues sensory epithelia. In this report, we show that function is required for differentiation Xenopus ectoderm. Microinjection dominant-negative forms (dnSox2) mRNA inhibits animal caps caused by attenuation BMP signals. Expression dnSox2 developing embryos suppresses expression N-CAM regional markers. We have analyzed temporal requirement Sox2-mediated signaling using...
Physical activity (PA) is a key determinant of health in older adults. However, little known about the effect social factors on PA among adults during coronavirus disease 2019 (COVID-19) pandemic. Therefore, we aimed to clarify association between socioeconomic status, participation, and A cross-sectional study was conducted 999 community-dwelling residents aged 65–90 years. self-administered questionnaire used collect data August 2020. Multivariable logistic regression analyses were...
Objective Cochlear nerve deficiency (CND) is often associated with poor cochlear implant (CI) outcomes, and patients CND may be candidates for auditory brainstem implantation (ABI). The purpose of this study was to identify investigations which predict CI outcomes immediately after recommend ABI within the critical period development when precedes ABI. Study Design Retrospective case review. Setting centers at tertiary referral hospitals. Patients Nineteen children who underwent...
Sulphated glycosaminoglycans (GAGs) attached to proteoglycan core proteins are implicated in cell adhesion, motility and morphogenesis. Variable sulphation patterns, which thought be important for regulating function, generated by sequential reactions during GAG biosynthesis. However, the mechanism such diversity is remains unclear.A novel sulphatase, designated RsulfFP1, was isolated from rat embryos screening floor plate specific genes. RsulfFP1 its orthologues show homology with other...
Cajal-Retzius (CR) cells are early-generated transient neurons and important in the regulation of cortical neuronal migration laminar formation. Molecular entities characterizing CR cell identity, however, remain largely elusive. We purified mouse expressing GFP to homogeneity by fluorescence-activated sorting examined a genomewide expression profile at embryonic postnatal periods. identified 49 genes that exceeded hybridization signals >10-fold compared with non-CR day 13.5, 2, or both....
Conclusion: Cochlear implantation was effective for deaf children with congenital cytomegalovirus (CMV) infection, but their cochlear implant (CI) outcomes were often impaired, depending on the types of CMV-associated psycho-neurological disorders. Evaluation cognitive development and autistic tendency implantees might be useful to predict CI outcomes. Objectives: To reveal influence disorders Methods: This a retrospective evaluation 11 CMV infection (CMV-CIs) 14 autosomal recessive hearing...
Primary culture of postnatal cerebellar granule cells provides a model system that recapitulates many molecular events developing in vivo . Depolarization cultured increases intracellular Ca 2+ and activates /calmodulin-dependent calcineurin (CaN) phosphatase. This signaling mimics some the for proliferation, migration, differentiation We investigated genome-wide expression profiles depolarization- CaN-regulated genes mouse addressed their relevance to gene regulation Granule were under...
Abstract Background Simultaneous bilateral cochlear implantation promotes symmetric development of auditory pathways but binaural hearing remains abnormal. To evaluate whether cortical processing impaired in such children, activity to unilateral and stimuli was assessed a unique cohort 16 children who received implants (CIs) simultaneously at 1.97 ± 0.86 years age had ~4 CI experience, providing the first opportunity assess electrically driven absence reorganized asymmetries from sequential...
Specialization of the auditory cortices for pure tone listening may develop with age. In adults, right hemisphere dominates when to tones and music; we thus hypothesized that (a) asymmetric function between increases age (b) this development is specific tonal rather than broadband/non-tonal stimuli. Cortical responses tone-bursts broadband click-trains were recorded by multichannel electroencephalography in young children (5.1 ± 0.8 years old) adolescents (15.2 1.7 normal hearing. Peak...
In a common cavity (CC) deformity, the cochlea and vestibule are confluent to form single without internal architecture, distribution of auditory neuronal tissue is unclear. The purposes this study reveal spatial in CC deformity using electrically evoked brainstem response (EABR) during cochlear implantation.Retrospective case review.Cochlear implant (CI) center at tertiary referral hospital.Five patients with who underwent implantation intraoperative EABR testing.Spatial electrodes that...
Accurate use of interaural time differences (ITDs) for spatial hearing may require access to bilateral auditory input during sensitive periods in human development. Providing cochlear implants (CIs) simultaneously promotes symmetrical development pathways but does not support normal ITD sensitivity. Thus, although binaural interactions are established by CIs the brainstem, potential deficits cortical processing ITDs remain. Cortical children with simultaneous and similar time-in-sound was...
Activation of cortical areas related to visual motion processing and control eye movement, deactivation parieto-insular vestibular cortices (PIVC) were revealed by functional magnetic resonance imaging (fMRI) with small-field optokinetic stimulation (OKS). The results agreed well those previous studies, which indicates that the current protocol is reliable enough be used as a clinical examination.To propose an fMRI set-up OKS simple performed test.Ten right-handed healthy volunteers...
Thymic carcinoma was found in a thymic cyst 60-year-old woman who admitted to our hospital due cough and pain her right chest. Chest X-ray showed huge shadow the mediastinum. CT scan cystic tumor with solid mass. An operation revealed cyst. Pathologic diagnosis squamous cell carcinoma, that contained some glandular tissues. The patient has been good condition for two years after operation. Although concurrent occurrence of is very rare, it should be added differential when anterior...
Abstract Human ACTG1 mutations are associated with high-frequency hearing loss, and patients in this gene good candidates for electric acoustic stimulation. To better understand the genetic etiology of loss cases, massively parallel DNA sequencing was performed on 7,048 unrelated Japanese probands. Among 1,336 autosomal dominant patients, we identified 15 probands (1.1%) 13 potentially pathogenic variants. Six variants were novel seven previously reported. We collected analyzed detailed...
Objective This study focused on the intensities of cochlear implant (CI) stimulation in pediatric CI users with inner ear malformation or nerve deficiency (CND). In this population, programming is difficult because a large intensity required to achieve sufficient hearing, but excess stimuli often induce facial stimulation. We aimed assess whether results intraoperative electrically evoked auditory brainstem responses (EABRs) testing predict maximum current levels (cC levels) optimized by...
Despite early bilateral cochlear implantation, children with congenital deafness do not develop accurate spatial hearing; we thus asked whether auditory brain networks are disrupted in these children. EEG responses were evoked unilaterally and bilaterally 13 normal hearing 16 receiving implants simultaneously. Active cortical areas estimated by the Time Restricted Artifact Coherent source Suppression (TRACS) beamformer connected identified measuring coherence between responses. A whole-brain...