A5089739186- Dementia and Cognitive Impairment Research
- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Motor Control and Adaptation
- Mental Health and Patient Involvement
- Genetic Neurodegenerative Diseases
- Health disparities and outcomes
- Health Literacy and Information Accessibility
- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Cognitive Functions and Memory
- COVID-19 and Mental Health
- Geriatric Care and Nursing Homes
- Chronic Disease Management Strategies
- Heart Rate Variability and Autonomic Control
- Action Observation and Synchronization
- Visual perception and processing mechanisms
- Alzheimer's disease research and treatments
- Technology Use by Older Adults
- Diet and metabolism studies
- Online Learning and Analytics
- Patient-Provider Communication in Healthcare
University of Tasmania
2016-2025
North Bristol NHS Trust
2024
Dementia Australia
2008-2017
Australian National University
2014
Monash University
2004-2009
The University of Melbourne
2007
Florey Institute of Neuroscience and Mental Health
2007
Swinburne University of Technology
1996-2003
<h3>Objective:</h3> Although the <i>APOE</i> ϵ<i>4</i> allele is associated with more rapid decline in memory healthy older adults, significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes cognition unclear. <h3>Methods:</h3> Healthy and cognitively normal adults (n = 141; mean age 76 years) underwent PET neuroimaging Aβ, genotyping, cognitive assessment as part their baseline Australian Imaging Biomarkers Lifestyle study. Cognitive function was reassessed 18 months...
Huntington's disease is a progressive neurodegenerative disorder that results in deterioration and atrophy of various brain regions.To assess the functional connectivity between prefrontal regions patients with disease, compared normal controls, using magnetic resonance imaging.20 17 matched controls performed Simon task known to activate lateral anterior cingulate cortical regions. The was hypothesised be impaired interest, selected from both hemispheres, dorsal cortex.Controls showed...
Dementia is a global public health priority and risk reduction an important pillar of the response. While 40% cases are estimated to be attributable modifiable lifestyle factors, awareness evidence low, limiting peoples’ opportunity adopt risk-reducing behaviours. To address this gap, we designed, implemented, evaluated educational intervention, Preventing Massive Open Online Course (PDMOOC). This mixed-methods study examined reach impact free globally available PDMOOC, assess its potential...
Background: Symptoms of attention-deficit/hyperactivity disorder (ADHD) have been associated with frontal lobe deficits.We used a novel brain electrical imaging method to investigate rapid and continuous changes in activity during the performance task (CPT) normal boys ADHD.The amplitude latency topography steady-state visually evoked potential (SSVEP) were examined while subjects performed "X" version CPT (CPT-X; reference task) "A-X" (CPT-AX).Methods: Seventeen meeting DSM-III-R criteria...
<h3>Objective</h3> The striatum and its projections are thought to be the earliest sites of Huntington9s disease (HD) pathology. This study aimed investigate progression striatal pathology in symptomatic HD using diffusion tensor imaging. <h3>Method</h3> Diffusion weighted images were acquired 18 patients 17 healthy controls twice, 1 year apart. Mean diffusivity (MD) was calculated caudate, putamen, thalamus corpus callosum, compared between groups. In addition, caudate width measured T1...
Abstract Introduction Recent evidence suggests that attention deficit hyperactivity disorder ( ADHD ) is associated with a range of brain functional connectivity abnormalities, one the most prominent being reduced inhibition default mode network DMN while performing cognitive task. In this study, we examine effects methylphenidate dose on in boys diagnosed they performed Method Brain was estimated using steady‐state visual evoked potential partial coherence before and 90 min after...
The development of attention and executive functions in normal children (7–12 years) was investigated using a novel selective reaching task, which involved as rapidly possible towards target, while at times having to ignore distractor. information processing paradigm allowed the measurement various distinct dimensions behaviour within single task. largest improvements vigilance, set-shifting, response inhibition, attention, impulsive responding were observed occur between ages 8 10, with...
This study utilised a finger force task to investigate the influence of attention and age on occurrence motor overflow in form mirror movements neurologically intact adults. Forty right-handed participants were recruited from three groups: 20–30 years, 40–50 60–70 years. Participants required maintain target using both their index middle fingers, representing 50% maximum strength capacity for that hand. Attention was directed hand by activating bone conduction vibrator attached small Based...
Abstract The development of attention and executive functions in normal children (7–12 years) was investigated using a novel selective reaching task, which involved as rapidly possible towards target, while at times having to ignore distractor. information processing paradigm allowed the measurement various distinct dimensions behaviour within single task. largest improvements vigilance, set-shifting, response inhibition, attention, impulsive responding were observed occur between ages 8 10,...
Objective: To compare the use of Continuous Performance Task (CPT) reaction time variability (intraindividual or standard deviation time), as a measure vigilance in attention-deficit hyperactivity disorder (ADHD), and stimulant medication response, utilizing simple CPT X-task vs an A-X-task. Method: Comparative analyses two separate A-X-task data sets, subgroup performance on off were conducted. Results: The had direct relationship to ADHD clinician severity ratings, unlike Variability was...
Up to 40% of incident dementia is considered attributable behavioral and lifestyle factors. Given the current lack medical treatments projected increase in prevalence, a focus on prevention through risk reduction needed.
Introduction: Timely post-diagnostic support is necessary to help people with dementia and those who provide care adapt the diagnosis optimise independence quality of life. However, evidence from carers regarding they need scarce. Aim: To explore perspectives their had been offered, barriers facilitators accessing such support, viewed as desirable or ideal. Method: This was a cross-sectional qualitative exploratory study. Data were collected individual interviews 13 recently diagnosed at...
Encouraging middle-aged adults to maintain their physical and cognitive health may have a significant impact on reducing the prevalence of dementia in future. Mobile phone apps interactive websites be one effective way target this age group. However, date there has been little research investigating user experience risk reduction tools delivered way.The aim study was explore participant engagement evaluations three different targeted smartphone Web-based following four-week...
Abstract Introduction Recent evidence suggests that attention‐deficit hyperactivity disorder ( ADHD ) is associated with brain functional connectivity FC abnormalities. Methods In this study, we use steady‐state visually evoked potential event‐related partial coherence as a measure of to examine differences between typically developing TD group 25 boys and an age/ IQ ‐matched 42 drug naive newly diagnosed group). Functional was estimated while both groups performed low‐demand reference task...
Abstract Introduction Containment measures implemented to minimize the spread of coronavirus disease 2019 (COVID‐19) are reported be negatively affecting mental health, diet, and alcohol consumption. These factors, as well poor cardiometabolic health insufficient physical cognitive activity, known increase risk developing dementia. COVID‐19 “lockdown” may have exacerbated these dementia factors among people in mid‐to‐later life. Methods We compared longitudinal data from before (October...
The stop signal task (stop task) is designed to assess inhibitory control and a frequently used research tool in clinical disorders such as ADHD schizophrenia. Previous methods of setting delay assessing are problematic. current study reports two modifications that improve the measure control. first modification was set delays proportional go mean reaction time (go MRT) better account for inter-subject variability MRT. Twenty-eight normal children were tested, all standard, dependent...
Previous studies on aging and attention typically examine group differences between younger older adults, rather than seeing as a continuous process. Using correlational analyses, this study examined progressive changes in the magnitude of attentional blink (AB) associated with aging. Increased age was found to be significantly ability detect second target (T2), whereby correlated production longer more pronounced AB; supports proposition that is reduced inhibitory processes selective...
This study investigated the influence of attentional and motor demands on overflow in 17 healthy young (18-35 years) older adults (60-80 years). Participants performed a finger pressing task by exerting either 33% or 66% their maximal force output using dominant nondominant hand. Overflow was concurrently recorded passive Attention manipulated via tactile stimulus presented to one both hands for certain trials. Results showed that exhibited greater than effect target exacerbated adults....