A5050624877- Reproductive Biology and Fertility
- Ovarian function and disorders
- Circadian rhythm and melatonin
- Reproductive Health and Technologies
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Empathy and Medical Education
- Estrogen and related hormone effects
- Stress Responses and Cortisol
- Clinical Reasoning and Diagnostic Skills
- Birth, Development, and Health
- Sperm and Testicular Function
- Menopause: Health Impacts and Treatments
- Innovations in Medical Education
- Cancer-related cognitive impairment studies
- Mesenchymal stem cell research
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2016-2024
Universidade de São Paulo
2018-2021
Fundação Faculdade de Medicina
2020
Weatherford College
2020
Universidad San Pedro
2004
Melatonin has anti-inflammatory and antioxidative actions at the mitochondrial level. This indole-containing molecule may protect ovarian grafts during process of cryopreservation. Therefore, we aimed to determine whether melatonin pretreatment improves rat graft quality.Twenty-six female rats were allocated two study groups thirteen animals each: 1) control group: ovaries cryopreserved using standard protocol; 2) in a medium with melatonin. Ten each group submitted 24-h freezing, whole...
The use of secretome may be a new strand cell therapy, which is equal to or even superior the injection live cells, called cell-free therapy. In ovarian transplantation, this approach therapeutic possibility for graft in hypoxia. We designed present study evaluate whether therapy with adipose tissue-derived stem cells (ASCs) rat frozen-thawed grafts could protect against ischemic injury. A single dose ASCs vehicle was injected into bilateral ovaries 18 adult female rats immediately after an...
Gelfoam scaffold is a feasible and safe non-invasive technique for Adipose tissue-derived Stem Cell (ASC)-delivery in the treatment of frozen-thawed ovarian autografts. This study seeks to analyze genes expression profile rat autografts treated with scaffold-based delivery adipose stem cells.Eighteen adult Wistar rats were distributed into three groups: Control (frozen-thawed only); Group 1 (G1) 2 (G2) ovaries culture medium or ASC, respectively). Both treatments performed immediately after...
The CA1 region of the hippocampus has an important role in learning and memory. It been shown that estrogen deficiency may reduce synaptic density hormone replacement therapy attenuate reduction. This study aimed to evaluate effects raloxifene on profile ovariectomized rats. Sixty three-month-old virgin rats were randomized into six groups (n = 10). Treatments started either three days (early treatment) or sixty (late after ovariectomy. received propylene glycol vehicle (0.5 mL/animal/day),...
Ovarian cryopreservation is a promising technique despite being hindered by damage from freezing and thawing. Melatonin can mitigate this outcome.
Abstract Background: Melatonin has anti-inflammatory and antioxidative actions at the mitochondrial level. This indole may protect ovarian graft during cryopreservation process. Therefore, our study aimed to determine whether melatonin pretreatment improves rat quality. Methods: Twenty female rats were allocated two groups of ten animals each: 1) control group: ovaries cryopreserved using standard protocol; 2) in a medium with melatonin. Following 24-h freezing, whole underwent autologous...
Apresenta-se uma proposta pedagógica, não habitual nas escolas médicas tradicionais, que introduz precocemente o aluno de graduação em um estágio observação da prática médica. Alunos do segundo semestre curso médico preparados para fazer participativa atendimento aos pacientes e entrevistas com profissionais saúde, desenvolveram a aprendizagem reflexão sobre comunicação profissional saúde sua clientela partir dos fatos observados. Resultados indicam experiência disciplina propiciou alunos...