A5049313833- Supramolecular Chemistry and Complexes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Analysis
- Innovative Education and Learning Practices
- Porphyrin and Phthalocyanine Chemistry
- Organizational Learning and Leadership
- Communication in Education and Healthcare
- Synthesis and Biological Activity
- Chemical synthesis and alkaloids
- Molecular Sensors and Ion Detection
- Reflective Practices in Education
- Diverse Music Education Insights
- Berberine and alkaloids research
- Supramolecular Self-Assembly in Materials
- Neuroscience and Neuropharmacology Research
- Luminescence and Fluorescent Materials
- Nicotinic Acetylcholine Receptors Study
- Cholinesterase and Neurodegenerative Diseases
- Social and Educational Sciences
University of Amsterdam
2018-2021
University of Copenhagen
2018
Incorporation of 2,5-dihydroxyterephthalate as a covalent scaffold in the axis 30-membered all-carbon macrocycle provides access to modular series rotaxanes. Installment tethered alkynes or azides onto terephthalic phenolic hydroxyl functionalities, which are situated at opposite sides macrocycle, gives versatile prerotaxane building blocks. The corresponding [2]rotaxanes obtained by introduction bulky stoppering ("capping") units tethers and subsequent cleavage ring/thread ester linkages....
After earlier unsuccessful attempts, this work reports the application of covalent templating for synthesis mechanically interlocked molecules (MiMs) bearing no supramolecular recognition sites. Two linear strands were covalently connected in a perpendicular fashion by central ketal linkage. subsequent attachment first strand to template via temporary benzylic linkages, second was linked backfolding macrocyclization. The resulting pseudo[1]rotaxane structure successfully converted...
The common para regioselectivity in Pictet-Spengler reactions with dopamine derivatives is redirected to the ortho position by a simple change of solvents. In combination chiral auxiliary on nitrogen, this ortho-selective produced 1-benzyltetrahydroisoquinoline alkaloids ( S)-crassifoline and S)-norcrassifoline bioactive 1,2-dioxygenated tetrahydroprotoberberine S)-govaniadine, S)-caseamine, S)-clarkeanidine high enantiopurity. Ortho/para ratios up 89:19 diastereomeric 85:15 were obtained...
The neurotransmitter metabolite 3,4-dihydroxy-phenylglycolaldehyde (dopegal) damages neurons and the myocardium by protein cross-linking, resulting in conglomerations cell death. We investigated this process on a synthetic scale, leading to discovery of an Amadori-type rearrangement dopegal reaction with several amino acids neuropeptides. This alkylation also occurs neurotransmitters, suggesting influence neurochemical processes. readily under physiological conditions.
Despite the advances in synthesis of mechanically interlocked molecules, a generally applicable approach to natural products, such as lasso peptides, is yet be formulated. While amino acid sequences have been introduced into several rotaxanes, key structural components always dictated by method used for supramolecular preorganization. In this work, we report use an ester-functionalized, aromatic δ-amino central covalent templating unit both [2]catenane and [2]rotaxane from same...
Universitetsuddannelsen i idræt integrerer læring af praktiske kompetencer og akademisk faglig fordybelse. I denne artikel præsenterer vi ”authentic microtea-ching” som model, hvor medbestemmelse formidlingsdimensionen indgår centrale fokusområder vores undervisning. Vores empiriske erfaringer med at ud-vikle modellen samt det lærings- uddannelsesstrategiske sigte beskrives udgangspunkt et specifikt kursus, studerende via små trefasede forløb bevæger sig fra være deltagere undervisning til...