A5101480224- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Endometriosis Research and Treatment
- Metastasis and carcinoma case studies
- Thyroid Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Intestinal and Peritoneal Adhesions
- Reproductive tract infections research
- Intraperitoneal and Appendiceal Malignancies
- Cancer Research and Treatments
- Endometrial and Cervical Cancer Treatments
- Wnt/β-catenin signaling in development and cancer
- Genetic factors in colorectal cancer
- Healthcare Systems and Reforms
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- FOXO transcription factor regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Ovarian function and disorders
- Cervical Cancer and HPV Research
- Reproductive Biology and Fertility
- Cancer Diagnosis and Treatment
- RNA modifications and cancer
Sichuan University
2020-2024
West China Second University Hospital of Sichuan University
2024
West China Hospital of Sichuan University
2020
China Medical University
1995-2015
First Hospital of China Medical University
2009-2015
Objective The 7th edition of AJCC staging manual implicitly states that only T1 and T2 lesions lack regional lymph node metastasis but have tumor deposit(s) will be classified in addition as N1c, though it is not consistent pN1c also an option for pT3/T4a tumors the table. Nevertheless, this TNM classification, how to classify deposits (TDs) colorectal cancer patients with (LNM) TDs simultaneously still clear. aim study investigate possibility counting metastatic nodes classification...
Abstract Vaginal dysbiosis often occurs in patients with cervical cancer. The fucosylation of mucosal epithelial cells is closely related to microbial colonization, and play an important role protecting the vaginal cells. However, no reports on relationship between abnormal cell fucosylation, their roles occurrence development cancer are unavailable. Here we report that core levels were significantly lower serum, exfoliated tumor tissue patients. Core fucosyltransferase gene (Fut8) knockout...
β-catenin, an epithelial-mesenchymal transition (EMT)-associated marker, is key in the progression of colorectal cancer (CRC). However, prognostic significance β-catenin expression patients with CRC remains controversial. In present study, at tumor invasive front and center was investigated, correlations amongst differential patterns clinicopathological characteristics prognosis were determined. total, 181 that diagnosed (as determined by histopathological evaluation) subjected to surgical...
Mesenchyme forkhead 1 (FoxC2) is an epithelial-mesenchymal transition (EMT)-inducing factor. Previous studies have demonstrated that FoxC2 binds directly to the promoter region of p120-catenin (p120ctn). The aim this study was investigate clinical significance expression and inter-relationship between p120ctn, in gastric cancer.Immunohistochemistry used examine p120ctn proteins 325 cancer samples. Staining for tissues markedly stronger than normal tissues. High associated significantly with...
Aims Accumulating evidence over the past decade has shown that abnormal activation of epithelial to mesenchymal transition ( EMT ) contributes tumour progression and metastasis in colorectal cancer CRC ). In this study, we investigated expression interleukin‐like inducer ILEI ‐associated markers (E‐cadherin, vimentin) tissues determined correlations between clinicopathological characteristics, prognosis . Methods results total, 194 patients diagnosed with based on histopathological...
Background: Uterine leiomyoma (UL) is one of the most common benign tumors in women, and its incidence gradually increasing China. The clinical complications UL have a negative impact on women's health, cost treatment poses significant burden patients. Diagnosis-related groups (DRG) are internationally recognized as advanced healthcare payment management methods that can effectively reduce costs. However, there variations design grouping rules DRG policies across different regions....
Abstract Mucinous breast cancer is a slow‐growing neoplasm, which has fewer lymph node metastases and favorable prognosis compared with invasive no special type. The hematogenous spread of mucinous carcinoma very rare. Though involving thyroid been reported before, there still report about metastatic in the literature. Recently by performing fine‐needle aspiration, 58‐year‐old woman who had 13 years ago was diagnosed as carcinoma, cellular variant neuroendocrine differentiation. For this...
Recent studies have revealed that glutamate decarboxylase 65 (GAD65) plays important roles in cancer progression. The role of GAD65 gastric development, progression and prognosis is currently unknown, we aimed to investigate this.Immunohistochemistry expression 313 tissues was significantly higher than 60 adjacent non-tumour tissues. Moreover, the level correlated with depth tumour invasion TNM stage. a significant prognostic factor univariate survival analysis, but did not remain an...
Objective To analyze the medical service pricing policy of 30 provinces and autonomous regions in China recommend on problems challenges, for reference reform future. Methods Literature review analysis were used summary performance appraisal China. Results Most areas surveyed followed step-by-step approach to gradually adjust pricing, while a few completed it one-time adjustment manner. 2015 witnessed most areas, up 20 (66.67%), price adjustment; their adjustments focused...
To explore the pharmacological mechanism of a Chinese patent drug (Kunling Pill (KLP)) on improving diminished ovarian reserve based proteomic analysis.A total 18 patients divided into three groups (the normal ovary (NOR), (DOR), and KLP groups) undergoing assisted reproductive technology by standard stimulation protocols were recruited to collect follicular fluid. Data-independent acquisition mass spectrometry was used identify differentially expressed proteins nano-LC-MS/MS. Bioinformatic...
AIM:To explore molecular mechanism of gastric carcinogenesis, we screened associated genes dysplasia and further investigated their expression in carcinomas with different stages. METHODS:Relatively pure normal tissue were procured by manual microdissection, amplified cDNAPCR, then used to carry out forward (dysplasia as tester, driver) reverse (normal SSH. Subtracted cDNA fragments cloned into vector, screened, sequenced, made homologous analysis. The differentially expressed was detected...
For 100 patients with gastric cancer, intraoperative intraperitoneal perfusion(IOIPP) using double - distilled water (D. D. W) hibitane 37°C for 5 minutes was performed. The anticancer effects were assessed cytologically in pre IOIPP and post-IOIPP specimens of the abdominal effusion and/or lavaged peritoneal fluid. radical gastrectomy performed 65 93 cases advanced shed cancer cells cavity detected 16 (24.62%) 3 post (4.62%). There significant difference between two groups (P<0.01). Shed...