A5050052875- Plant Reproductive Biology
- Lipid metabolism and biosynthesis
- Photosynthetic Processes and Mechanisms
- Plant biochemistry and biosynthesis
- Plant Molecular Biology Research
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Plant Surface Properties and Treatments
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- RNA modifications and cancer
University of Göttingen
2019-2022
Universitätsmedizin Göttingen
2022
The developmental program of seed formation, germination, and early seedling growth requires not only tight regulation cell division metabolism, but also concerted control the structure function organelles, which relies on specific changes in their protein composition. Of particular interest is switch from heterotrophic to photoautotrophic growth, for cytoplasmic lipid droplets (LDs) play a critical role as depots energy-rich storage lipids. Here, we present results bottom-up proteomics...
Membrane contact sites (MCSs) are interorganellar connections that allow for the direct exchange of molecules, such as lipids or Ca2+ between organelles, but can also serve to tether organelles at specific locations within cells. Here, we identified and characterized three proteins Arabidopsis thaliana form a lipid droplet (LD)-plasma membrane (PM) tethering complex in plant cells, namely LD-localized SEED LD PROTEIN (SLDP) 1 SLDP2 PM-localized LD-PLASMA MEMBRANE ADAPTOR (LIPA). Using...
Pancreatic Ductal Adenocarcinoma (PDAC) represents a lethal malignancy with consistently poor outcome. Besides mutations in PDAC driver genes, the aggressive tumor biology of disease and its remarkable therapy resistance are predominantly installed by potentially reversible epigenetic dysregulation. However, regulators act context-dependent manner opposing implication on progression, thus critically determining therapeutic efficacy targeting. Herein, we aimed at exploring molecular...
Aminoacylation of transfer RNA (tRNA) is a key step in protein biosynthesis, carried out by highly specific aminoacyl-tRNA synthetases (ARSs). ARSs have been implicated autosomal dominant and recessive human disorders. Autosomal variants tryptophanyl-tRNA synthetase 1 (WARS1) are known to cause distal hereditary motor neuropathy Charcot-Marie-Tooth disease, but recessively inherited phenotype yet be clearly defined. Seryl-tRNA (SARS1) has rarely an developmental disorder. Here, we report...
After reaching the stigma, pollen grains germinate and form a tube that transports sperm cells to ovule. Due selection pressure between tubes, likely evolved mechanisms quickly adapt temperature changes sustain elongation at highest possible rate. We investigated these adaptions in tobacco (Nicotiana tabacum) tubes grown vitro under 22°C 37°C by multi-omics approach including lipidomic, metabolomic, transcriptomic analysis. Both glycerophospholipids galactoglycerolipids increased saturated...
ABSTRACT Membrane contact sites (MCS) are inter-organellar connections that allow for the direct exchange of molecules, such as lipids or Ca 2+ between organelles, but can also serve to tether organelles at specific locations within cells. Here we identified and characterised three proteins form a lipid droplet (LD)-plasma membrane (PM) tethering complex in plant cells, namely LD-localised SEED LD PROTEIN (SLDP) 1 2 PM-localised LD-PLASMA MEMBRANE ADAPTOR (LIPA). Using proteomics different...
Abstract After reaching the stigma, pollen grains germinate and form a tube that transports sperm cells to ovule. Due selection pressure between tubes, they likely evolved mechanisms quickly adapt temperature changes sustain an elongation at highest possible rate. We investigated these adaptions in Nicotiana tabacum tubes grown vitro under 22 °C 37 by multi-omic approach including lipidomic, metabolomic transcriptomic analysis. Both glycerophospholipids galactoglycerolipids increased...