A5044636381- TGF-β signaling in diseases
- Connective tissue disorders research
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Developmental Biology and Gene Regulation
- Legal Systems and Judicial Processes
- American Constitutional Law and Politics
- Judicial and Constitutional Studies
- Ocular Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Bone and Dental Protein Studies
- Occupational and environmental lung diseases
- Microbial metabolism and enzyme function
- melanin and skin pigmentation
- Cancer Cells and Metastasis
- Legal Education and Practice Innovations
- Kruppel-like factors research
- Property Rights and Legal Doctrine
- Congenital Ear and Nasal Anomalies
- Signaling Pathways in Disease
- Diverse Educational Innovations Studies
- Cancer-related gene regulation
- Education Systems and Policy
- Peptidase Inhibition and Analysis
- Proteoglycans and glycosaminoglycans research
University Hospital Cologne
2021-2025
University of Cologne
2013-2022
MFAP4 (microfibrillar-associated protein 4) is an extracellular glycoprotein found in elastic fibers without a clearly defined role fiber assembly. In the present study, we characterized molecular interactions between and components. We established that primarily assembles into trimeric hexameric structures of homodimers. Binding analysis revealed specifically binds tropoelastin fibrillin-1 -2, as well elastin cross-linking amino acid desmosine, it co-localizes with fibrillin-1-positive...
Significance Bone morphogenetic proteins (BMPs) are essential signaling molecules important in embryo development and maintaining tissue function adulthood. BMPs regulated outside the cell by inhibitors such as chordin. The structure of chordin is unknown extracellular generally not suitable for high-resolution methods. This study uses electron microscopy other techniques to determine shape human It has a compact horseshoe-shaped with terminal BMP-binding regions protruding prongs. spacing...
Recent studies have revealed an important role for LTBP-4 in elastogenesis. Its mutational inactivation humans causes autosomal recessive cutis laxa type 1C (ARCL1C), which is a severe disorder caused by defects of the elastic fiber network. Although human gene involved ARCL1C has been discovered based on similar abnormalities exhibited mice lacking short Ltbp-4 isoform (Ltbp4S(-/-)), murine phenotype does not replicate ARCL1C. We therefore inactivated both isoforms mouse germline to model...
Malignant mesothelioma is a form of cancer that highly resistant to conventional therapy for which no major therapeutic advances have been introduced. Here, we identify gremlin-1, known bone morphogenetic protein inhibitor crucial embryonic development, as potential target mesothelioma. We found high expression levels gremlin-1 in the tumor tissue, well primary cells cultured from pleural effusion samples. Downregulation by siRNA-mediated silencing cell line inhibited proliferation. This was...
Bone morphogenetic protein 10 (BMP-10) is crucial for endothelial cell signaling via activin receptor-like kinase 1 (ALK1), a pathway central to vascular homeostasis and angiogenesis. Dysregulated BMP-10 contributes cardiovascular diseases cancer, highlighting the need control ALK1-mediated responses therapeutic development. biosynthesis involves processing by proprotein convertases (PPCs) resulting in non-covalently associated prodomain-growth factor (PD-GF) complex (CPLX), similar other...
Twisted gastrulation (Tsg) and chordin are secreted glycoproteins that function together as BMP (bone morphogenetic protein) antagonists to regulate growth factor signalling. Chordin binds BMPs, preventing them from interacting with their receptors Tsg is known strengthen this inhibitory complex. also acts a agonist by promoting cleavage of tolloid-family proteinases. Here we explore the structural mechanism through which exerts dual activity. We have characterized nanoscale structure human...
Since their discovery as pluripotent cytokines extractable from bone matrix, it has been speculated how morphogenetic proteins (BMPs) become released and activated the extracellular matrix (ECM). In contrast to TGF-βs, most investigated BMPs are secreted bioactive prodomain (PD)–growth factor (GF) complexes (CPLXs). Recently, we demonstrated that PD-dependent targeting of BMP-7 CPLXs fibrillin microfibril (FMF) components fibrillin-1 -2 represents a BMP sequestration mechanism by rendering...
Bone morphogenetic proteins (BMP) are powerful regulators of cellular processes such as proliferation, differentiation, and apoptosis. However, the specific molecular requirements controlling bioavailability BMPs in extracellular matrix (ECM) not yet fully understood. Our previous work showed that targeted to ECM growth factor-prodomain (GF-PD) complexes (CPLXs) via interactions their PDs. We BMP-7 PD binding microfibril component fibrillin-1 renders CPLXs from an open, bioactive V-shape...
Tom Clark’s Transition from Attorney General to Supreme Court Justice ALEXANDER WOHL When Clark accepted President Truman’s offer be General, the told him “pick out somebody for SolicitorGeneral who, in event you go, I’ll have another man—I won’t look all over country and wait around get me man General.”1 Whether this oblique comment meant that Truman was thinking even then ofClark fill a future vacancy cannot known. It seems likely, however, given four of high court appointments—Harold H....
When Supreme Court Justice Tom Clark resigned his seat on the bench at youthful age of 67 after 18 years, decision was unique in annals history: he leaving so that son Ramsey, just nominated as Attorney General, could assume job himself had once held without conflict interest. As Alexander Wohl shows, and Ramsey a profound impact American law society. For nearly three quarters century, they influenced presidents, policies, legal rulings, during careers tracked closely with some most...
The Life ofJohn Marshall Revisited AlexanderWohl While perusing the law section of a used bookstore recently, I was pleased to find for only thirty dollars somewhat worn, but handsomelybound copy ofAlbertBeveridge’s classicfour-volumeThe LifeofJohnMarshall. Having intended some time read this Pulitzer Prize-winning biography, eagerly snatched it up, pausing briefly consider $250.00 set that had been autographedby author. interestedto see how masterpiece stood test since 1916, when first two...