19th century descriptions of cysts in the popliteal region or calf communicating with knee included those Adams (1840) and Baker (1877, 1885), these phenomena are often called Baker's cysts.Baker clearly recognized possibility acute rupture occurring cysts.Recently Dixon Grant (1964) have described five patients rheumatoid arthritis whom they diagnosed synovial a effusion into calf.The present paper describes use contrast arthrography studying twenty who presented during past 2 years either...

Patients with falciparum malaria were studied in Thailand, an area of known chloroquine resistance. The patients unselected and some had severe malaria, they randomly assigned to one two sequential regimes. A short course quinine (average 4 doses, equivalent 2 g base) followed by a single dose pyrimethamine-sulfadoxine (Fansidar) cured 92% (36 out 39), while 1-5-dose mefloquine all the 35 who could be up. Gastrointestinal side effects minimal if at least 12 hours elapsed between last...

Amodiaquine cured 38% (13/34) of patients with falciparum malaria in Southeast Thailand. Chloroquine 0% (0/13). The cure rates amodiaquine were the same whether a 1.5 g or 2.0 course was used. Most resistant to at RI level and chloroquine RII level. In hospital, cleared parasitemia more frequently than did chloroquine. With amodiaquine, parasite clearance time 77 hours; fever 36 hours low suggests that does not cause drug fever. Because resistance, should be used for Routine use is indicated...

Using a crossover design, 12 healthy male volunteers received 3 forms of quinine in day courses random sequence at weekly intervals. Enteric‐coated tablets and gelatin capsules sulfate (540 mg base) were given orally every 8 hours for days (1.62 gm base daily), dihydrochloride (490 was as continuous intravenous infusion (1.47 daily). Drug‐related toxicity included headache, tinnitus, liver dysfunction. Form‐related toxicities nausea, abdominal pain, diarrhea with oral administration...

In order to investigate the role that human T-lymphotropic virus type I (HTLV-I) tax oncogene plays in apoptosis and transformation vivo, four lines of HTLV-I transgenic mice were generated under regulatory control CD3-ϵ promoter–enhancer sequence. These develop a variety phenotypes including mesenchymal tumours, which at wound sites, salivary mammary adenomas. situ DNA fragment labelling immunocytochemical analysis these tumours reveals they display enhanced levels apoptosis, is associated...

Two new investigational antimalarial drugs developed by the U.S. Army Malaria Research Program were tested in patients with multi-drug-resistant falciparum malaria from Vietnam. WR 33063, a phenanthrene methanol, cured 13 treated United States. All of these had suffered multiple recrudescences after treatment standard drugs. In addition, 23 25 acute attacks Vietnam cured. The rate clinical response was prompt. 30090, quinoline similarly eight States and 26 Adverse effects associated not...

Quinine (at least four doses given at intervals of eight to 12 hours) followed by a single dose sulfadoxine-pyrimethamine (Fansidar) is the most effective treatment chloroquine-resistant falciparum malaria. This regimen cured 96% patients (302 out 314) with an average initial parasite count 90 X 10-9/1.

Clindamycin, a semi-synthetic antibiotic of the lincomycin family, at dose 450 mg eight-hourly for three days in adults cured five out 10 patients moderately ill with chloroquine-resistant falciparum malaria. Combination therapy full-dose quinine and clindamycin all four so treated who were followed up, half dosage cured. Both combinations, however, caused upper gastrointestinal toxicity appeared to potentiate both possibly antimalarial efficacy. Colitis due was not observed. Sequential...

AZD7969 is a potent inhibitor of glycogen synthase kinase 3 (GSK3β), which multifunctional serine/threonine that negatively regulates the Wnt/β-catenin signaling pathway. Treatment rats and dogs with for periods up to 4 weeks resulted in number changes, most significant was dose-dependent, treatment-related, increase proliferation tissues thought arise from derepression stem cell compartment. Phenotypically, this hyperplasia either maintained normal tissue architecture gastrointestinal...

SUMMARY A case history of acute generalized exanthematous pustulosis (AGEP) following oral terbinafine is reported. 64‐year‐old woman presented with a rapidly spreading micropustular eruption 3 days after completing 28‐day course terbinafine. There was positive family psoriasis but no personal history. The clinical presentation and histopathology were consistent AGEP. nearly complete resolution the pustular within 3.5 weeks cessation treatment topical systemic corticosteroids. patient has...

The growth plate, ovary, adrenal gland, and rodent incisor tooth are sentinel organs for antiangiogenic effects since they respond reliably, quantitatively, sensitively to inhibition of the vascular endothelial factor receptor (VEGFR). Here we report that treatment rats with platelet-derived beta (PDGFRβ) inhibitors target pericytes results in severe ovarian hemorrhage degeneration eventual rupture corpus luteum. Evaluation typical revealed no abnormalities. Histologically, changes ovary...

Quinine was compared with a 9-phenanthrene methanol (WR33063) and 4-quinoline (WR30090) for the treatment of 207 patients falciparum malaria in Southeast Thailand. eradicated parasitaemia (average 70 hours) more rapidly than either WR30090 (72 or WR33063 (77 hours). But had higher cure rate (92%) (86%) quinine (85%). The mean duration fever were combined failure to form an arbitrary efficacy index. Using this concept most effective drug. recrudescence correlated degree fever. least toxic...

Lichen planus (LP) is an incompletely understood T-cell mediated auto-immune dermatosis. When LP involves the genitalia it may present as painful, pruritic erosions that can be exquisitely tender, causing distress and genitourinary sexual dysfunction. Management of erosive genital often suboptimal. Despite higher order evidence demonstrating efficacy oral acitretin in management cutaneous LP, still features below other immunosuppressive immunomodulatory therapies many clinicians' therapeutic...