A5102785381- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Circular RNAs in diseases
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Vascular anomalies and interventions
- Renal and Vascular Pathologies
- RNA modifications and cancer
- Pulmonary Hypertension Research and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Barrier Structure and Function Studies
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Central Venous Catheters and Hemodialysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Thallium and Germanium Studies
- Cerebral Venous Sinus Thrombosis
- Cancer, Stress, Anesthesia, and Immune Response
- Galectins and Cancer Biology
First Affiliated Hospital of Zhengzhou University
2009-2023
Zhengzhou University
2013
Increasing evidence demonstrated that TPX2 was highly expressed and tightly associated with human tumor development progression. However, its precise role in bladder carcinoma remains to be delineated. In the present study, we revealed high expression of at both mRNA protein levels tissues cells, pN1-3 pT2-4 status were significantly higher than those pN0 pTa-T1 status, respectively. Additionally, level strongly pT (P = 0.001), histological grade lymph node metastasis 0.022), shorter...
To report our techniques and experience of laparoscopic extravascular stent placement for nutcracker syndrome.This study included 13 syndrome patients who were treated by from June 2009 to August 2013. Clinical surgical data short-term outcomes analyzed retrospectively.The average duration the operation was 72 minutes blood loss 30 mL. The postoperative length stay 6 days. Retroperitoneal hematoma relieved conservative therapy in one patient. computed tomography showed that outflow left...
Aberrantly expressed microRNAs (miRs) are extensively involved in tumorigenesis. microRNA-340 (miR-340) has been reported as a tumor suppressor various cancer types. However, whether miR-340 plays an important role prostate remains unknown. This study aims to investigate the expression pattern of and its functional significance cancer. Results showed that was frequently downregulated human cell lines tissues. overexpression suppressed proliferative invasive properties cells. also promoted...
Abstract Background Clear cell renal carcinoma (ccRCC) is the most common subtype with a poor prognosis. LncRNA-LET long non-coding RNA (lncRNA) that down-regulated in ccRCC tissues. However, its role development and progress unclear. Methods expression was detected tissues cells using quantitative real-time PCR. The overexpression knockdown experiments were performed xenograft mouse model to evaluate of lncRNA-LET. Cell cycle, apoptosis JC-1 assays conducted via flow cytometer. protein...
The synthetic biology technology which enhances the specificity and efficacy of treatment is a novel try in biomedical therapy during recent years. A high frequency somatic mutations was shown human telomerase reverse transcriptase (hTERT) promoter bladder cancer, indicating that mutational hTERT might be tumor-specific element for cancer therapy. In our study, we aimed to construct combination module driven by super artificial investigate its influence on malignant phenotypes cancer. dual...
Pulmonary fibrosis (PF) is a destructive pulmonary disease and the molecular mechanisms underlying PF are unclear. This study investigated differentially expressed proteins associated with occurrence development of in rat lung tissue bleomycin-induced PF.Sixteen Sprague-Dawley rats were randomly divided into 2 groups: model group (n = 8) control 8). After successfully establishing induced by bleomycin, groups identified through isobaric tag for relative absolute quantitation coupled liquid...
Magnesium isoglycyrrhizinate (MI), a magnesium salt of 18α-GA stereoisomer, has been reported to exert efficient hepatoprotective activity. However, its effect on bladder cancer remains unclear. The study explored the effects MI growth, colony formation, apoptosis, invasion, and migration cells (HTB9 BIU87 cells). Typical apoptotic changes such as nuclear concentration fragmentation were observed using Hoechst staining. expression levels microRNA-26b (miR-26b), NADPH oxidase 4 (Nox4),...
Background Elongation factor for RNA polymerase 2 (ELL2) and ELL associated (EAF2) have been reported to tumor suppressive properties in prostate epithelial cells. Aims We investigated ELL2 expression human cancer specimens, protein stability ubiquitination Materials Methods Immunostaining analysis of specimens was used determine normal tissues. knockdown cell lines LNCaP C4‐2 compare proliferation motility. Deletion site‐directed mutagenesis identify amino acid residues that were important...
Objective To report our experience of retroperitoneal laparoscopic extravascular stent placement for nutcracker syndrome. Methods The clinical data 12 syndrome patients (10 males and 2 females; mean age 26 years) who underwent from March 2014 to Febuary 2016 were retrospectively reviewed. The main symptoms gross hematuria in 8 patients(one with proteinuria)and flank pain was noted 1 patient. Three male had left-sided secondary varicoceles. Ultrasonography computed tomography showed...
Objective To explore the expression of Tiaml in clear cell renal carcinoma and analyze its correlations to pathology disease prognosis.Methods The expressions Tiam1 protein 107 specimens human 20 normal tissues were detected by immunohistochemical staining clinical significance was then analyzed.Results higher cancers than adjacent ( P ＜ 0.01 ).Tiam1 rates 47.6％ 72.7％ Ⅰ - Ⅱ Ⅲ Ⅳ tumors,while 49.3％ 76.5％ T1 T2 T3 T4 tumors,respectively ).Expression lymph node positive negative 71.7％ versus...
Objective To investigate the clinical effects of ureteroscopic lithotripsy combined with ureteral catheter irrigation in treating calculus.Methods Two hundred and fifty-two patients calculus from June 2010 to 2012 underwent after placement F4 into ureter.Results Of 252 patients,250 cases were treated successfully,the success rate was 99.2％,and average operations time 15 65 min.No serious complication occurred.Conclusions Ureteroscopic hthotripsy leads better visibility surgical...
Objective To explore the expression of nerve growth factor receptors p75 (p75NGFR) in human bladder carcinoma samples, and effects hypoxia on p75NGFR cancer ceils. Methods The 107 lymph node specimens were immunohistochemically investigated. cell line (T24) was assessed by immunocytochemistry, reverse tran-scription-PCR Normoxic Condition (air, 5%CO2) condition(10%O2, 5%CO2, 85%N2). Results expressed 46 107(43.0%) tumor samples. There no signifi-cant correlation between factors such as...
Objective To explore the expression of aquaporin1 and aquaporin3 in donor lung with warm ischemia, study whether the,expression level aquaporinl is related to acute injury caused by ischemia. Methods Adult Wistar rats were divided into 3 groups ac-cording ischemic time 0 h (group A,n = 10) ,1 B,n ,and 2 C, n 10). We examined AQP1 AQP3 protein mRNA tissues immunohistochemistry, Western blotting, reverse transcriptase-polymerase chain reaction. Results Immunohistochemical examination revealed...
Abstract Background: Magnesium Isoglycyrrhizinate (MI), a magnesium salt of 18α-GA stereoisomer, has been reported to exert efficient hepatoprotective activity. However, its effect in bladder cancer remain unclear. Methods: The MI the growth, colony formation, apoptosis, invasion and migration cells (HTB9 BIU87 cells) was evaluated vitro . Typical apoptotic changes such as nuclear concentration fragmentation observed by Hoechst staining. expression miR-26b, Nox4, NF-κB HIF-1α detected...