A5025099295- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Organoboron and organosilicon chemistry
- Advanced NMR Techniques and Applications
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Solid-state spectroscopy and crystallography
- Conducting polymers and applications
- Metal-Organic Frameworks: Synthesis and Applications
- Luminescence and Fluorescent Materials
- Porphyrin and Phthalocyanine Chemistry
- Pelvic floor disorders treatments
- Boron and Carbon Nanomaterials Research
- Inorganic Fluorides and Related Compounds
- Advanced Fluorescence Microscopy Techniques
- Retinoids in leukemia and cellular processes
- Lipid Membrane Structure and Behavior
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Catalytic C–H Functionalization Methods
- Asthma and respiratory diseases
- Drug Solubulity and Delivery Systems
- Phosphodiesterase function and regulation
- Molecular Sensors and Ion Detection
Chiesi (Italy)
2023-2024
Chiesi Foundation
2022
University of Bologna
2018-2020
University of Parma
2018
Using a commercially available potentiostat, the electrochemical synthesis of unnatural amino acids bearing heteroaromatics on lateral chain has been accomplished. This strategy exploits side-chain decarboxylative arylation aspartic/glutamic acid, reaction that becomes challenging with electron-rich coupling partners such as 5- and 6-membered heteroaromatics. These rings are underrepresented in acids, therefore allowing wider exploration chemical space, given abundance aryl bromides...
Plastic crystals are solids characterized by disorder–order transitions that often exploitable for the realization of functional materials. A major challenge in design such materials lies difficulty both predicting and tailoring phase stability relative transitions. Herein we describe a simple approach modulation plastic transition ferroelectric salts (R)-3-hydroxlyquinuclidinium chloride bromide, [QH]Cl [QH]Br, based on formation solid solutions. Mixed formula [QH]ClxBr1–x could be prepared...
Zn-to-Co transmetalation of IRMOF-9 introduces major structural changes.
The order-disorder phase transition associated with the uprise of reorientational motion in (DABCOH2)2+ , supramolecular salts general formula [1⋅(DABCOH2 )]X2 (where 1=12-crown-4, DABCO=1,4-diazabicyclo[2.2.2]octane, and X=Cl- or Br- ), has been investigated by variable temperature X-ray diffraction on single crystals powder samples, as well DSC solid-state NMR spectroscopy (SSNMR). two compounds undergo a reversible change at 292 290 K, respectively. crystalline materials form solid...
Aiming at the inhaled treatment of pulmonary diseases, optimization process previously reported MAPI compound 92a is herein described. The project was focused on overcoming chemical stability issue and achieving a balanced bronchodilator/anti-inflammatory profile in rats order to be confident clinical effect without having overdose one biological targets. strategy based fine-tuning substitution pattern muscarinic PDE4 structural portions dual pharmacology compounds, also making use analysis...
Herein we report that 4-pyridinylboronic acid (1) in the solid state self-assembles into tetrameric macrocycles via B–N bond formation. The tetramers are linked O–H···O bonds resulting a material can be exfoliated sonication to give thinner sheets as demonstrate Fourier transform infrared spectroscopy, transmission electron microscopy, selected area diffraction, and atomic force microscopy experiments. For comparison, structure of related compound 4-(pyridin-4-yl) phenylboronic (2) is also discussed.
The structures and solid-state dynamics of the supramolecular salts general formula [(12-crown-4)2 ⋅DABCOH2 ](X)2 (where DABCO=1,4-diazabicyclo[2.2.2]octane, X=BF4 , ClO4 ) have been investigated as a function temperature (from 100 to 360 K) pressure (up 3.4 GPa), through combination variable-temperature variable-pressure XRD techniques NMR spectroscopy. two are isomorphous crystallize in enantiomeric space groups P32 21 P31 . All building blocks composing complex display dynamic processes...
Using a commercially available potentiostat, the electrochemical synthesis of unnatural amino acids bearing heteroaromatics on lateral chain has been accomplished. This strategy exploits side-chain decarboxylative arylation aspartic/glutamic acid, reaction that becomes challenging with electron-rich coupling partners such as 5- and 6-membered heteroaromatics. These rings are underrepresented in acids, therefore it allowed wider exploration chemical space, also given abundance aryl bromides...
Sustained released formulation is the most used strategy to control efficacy and adverse reactions of an API (active pharmaceutical ingredient) with a narrow therapeutic index. In this work, we different way tailor solubility diffusion drug. Salification Theophylline Squaric Acid was carried out better absorption after administration. proved be winning decreasing dissolution APIs up 54% respect Theophylline. Most importantly, accomplished in first 10 min process, which are important for Two...
The boronic acid derivatives 4‐pyridinylboronic (4‐pyBA) and pyrimidine‐5‐boronic (pyrBA) have been reacted with the oxocarbon rhodizonic or sodium rhodizonate both in solution solid state. Four novel condensation adducts isolated as hydrates, namely C 16 H B 2 N O 12 · x ( 1a· O; = 4), 14 10 3H 2a· O), 4 2.5H 1b· 2b· fully characterized by X‐ray single crystal powder diffraction. Their thermal stability behavior upon dehydration also investigated TGA single‐crystal to diffraction...
Using a commercially available potentiostat, the electrochemical synthesis of unnatural amino acids bearing heteroaromatics on lateral chain has been accomplished. This strategy exploits side-chain decarboxylative arylation aspartic/glutamic acid, reaction that becomes challenging with electron-rich coupling partners such as 5- and 6-membered heteroaromatics. These rings are underrepresented in acids, therefore it allowed wider exploration chemical space, also given abundance aryl bromides...
Fluorescence lifetime imaging microscopy (FLIM) is used to study the supramolecular organization of liposomal all- trans retinoic acid (ATRA), exploiting its intrinsic fluorescence as signal and phasor transformation a fit-free analytical tool.
We report a novel heterodimeric charge-assisted hydrogen bonding synthon and prove its robustness by preparation of three-component co-crystal.