A5038838969- Geological and Geochemical Analysis
- earthquake and tectonic studies
- High-pressure geophysics and materials
- Geochemistry and Geologic Mapping
- Geology and Paleoclimatology Research
- Geochemistry and Elemental Analysis
- Paleontology and Stratigraphy of Fossils
- Geological and Geophysical Studies
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Geomagnetism and Paleomagnetism Studies
- Geological and Geophysical Studies Worldwide
- Geological Studies and Exploration
- Hydrocarbon exploration and reservoir analysis
- Pancreatic and Hepatic Oncology Research
- Groundwater and Isotope Geochemistry
- Neuroblastoma Research and Treatments
- Groundwater flow and contamination studies
- Geophysical and Geoelectrical Methods
- Pancreatic function and diabetes
- Evolution and Paleontology Studies
- Clay minerals and soil interactions
- Advanced Optical Imaging Technologies
- Radioactive element chemistry and processing
- Geological formations and processes
University of Rochester Medical Center
2024-2025
University of Rochester
2021-2024
University of Cape Town
2014-2023
Rutgers, The State University of New Jersey
2010-2020
Rutgers Cancer Institute of New Jersey
2010-2020
Arthur M. Sackler Gallery
2009-2020
Johnson University
2016-2020
University of Otago
2018
Murdoch University
2013
Memorial Sloan Kettering Cancer Center
2012
Cancers comprise a heterogeneous group of human diseases. Unifying characteristics include unchecked abilities tumor cells to proliferate and spread anatomically, the presence clonal advantageous genetic changes. However, universal highly specific markers are unknown. Herein, we report widespread long interspersed element-1 (LINE-1) repeat expression in cancers. We show that nearly half all cancers immunoreactive for LINE-1-encoded protein. LINE-1 protein is common feature many types...
In cancer cells, the aberrant conversion of pyruvate into lactate instead acetyl-CoA in presence oxygen is known as Warburg effect. The consequences and mechanisms this metabolic peculiarity are incompletely understood. Here we report that p53 status a key determinant Wild-type expression decreased levels dehydrogenase kinase-2 (Pdk2) product its activity, inactive form complex (P-Pdc), both which regulators metabolism. Decreased Pdk2 P-Pdc turn promoted lactate. Thus, wild-type limited...
Iron is the most important metal for modern industry and Sweden by far largest iron-producer in Europe, yet genesis of Sweden's main iron-source, 'Kiruna-type' apatite-iron-oxide ores, remains enigmatic. We show that magnetites from central Swedish deposit at Grängesberg have δ(18)O values between -0.4 +3.7‰, while 1.90-1.88 Ga meta-volcanic host rocks +4.9 +9‰. Over 90% magnetite data are consistent with direct precipitation intermediate to felsic magmas or magmatic fluids high-temperature...
Abstract Kiruna-type apatite-iron-oxide ores are key iron sources for modern industry, yet their origin remains controversial. Diverse ore-forming processes have been discussed, comprising low-temperature hydrothermal versus a high-temperature from magma or magmatic fluids. We present an extensive set of new and combined oxygen isotope data magnetite Sweden, Chile Iran, compare them with global reference layered intrusions, active volcanic provinces, established ores. show that approximately...
Abstract Catastrophic lava dome collapse is considered an unpredictable volcanic hazard because the physical properties, stress conditions, and internal structure of domes are not well understood can change rapidly through time. To explain locations instabilities at Merapi volcano, Indonesia, we combined geochemical mineralogical analyses, rock property measurements, drone-based photogrammetry, geoinformatics. We show that a horseshoe-shaped alteration zone formed in 2014 was subsequently...
Field mapping and petrological-geochemical investigation of the Jinchuan intrusion in north-central China clarifies how was emplaced provides a new model that explains its large rich Ni-Cu-platinoid deposits may have formed. The into high-grade gneisses marbles along disconformity at base an overlying cover sequence, indicating it as sill, not near-vertical dike, previously proposed. After emplacement rotated to present orientation deformed metamorphosed under greenschist-facies conditions....
In mice, genetic changes that inactivate the retinoblastoma tumor suppressor pathway often result in pancreatic neuroendocrine tumors (Pan-NETs). Conversely, humans with this disease, mutations genes of have rarely been detected, even genome-wide sequencing studies. study, we took a closer look at role human Pan-NETs.Pan-NET from 92 patients were subjected to immunohistochemical staining for markers pathway. To search amplifications genes, genomic DNAs 26 copy number analysis. Finally,...
The Platreef is the main platinum group element (PGE)-bearing facies of northern limb Bushveld complex, but unlike Merensky Reef eastern and western limbs, it in direct contact with country rock. Mineral separate δ18O values for samples from Upper Zone Main indicate crystallization a well-mixed, already contaminated, magma having value 7·5‰. Pyroxenes pyroxenites at Sandsloot Mine have that are up to 2·4‰ higher than pyroxenes Zones. These differences can be explained by additional...
ABSTRACT SecY and SecE are integral cytoplasmic membrane proteins that form an essential part of the protein translocation machinery in Escherichia coli . Sites direct contact between these two have been suggested by allele-specific synthetic phenotypes exhibited pairwise combinations prlA prlG signal sequence suppressor mutations genes. We introduced cysteine residues within first periplasmic loop second SecE, at a specific pair positions identified this genetic interaction. The expression...
Nanotechnology is the new industrial revolution of 21st Century as various processes lead to radical improvements in medicine, manufacturing, energy production, land remediation, information technology and many other everyday products applications. With this however, there are undoubted concerns for health, safety environment which arise from unique nature materials at nanometre scale.The vitro assays used screening strategy all validated, internationally accepted protocols provide a useful...
Within healthy human somatic cells, retrotransposition by long interspersed nuclear element-1 (also known as LINE-1 or L1) is thought to be held in check a variety of mechanisms, including DNA methylation and RNAi. The expression L1-ORF1 protein, which rarely found normal tissue, was assayed using antibodies with clinical cancer specimens cell lines. L1-ORF1p detected nearly all breast tumors that the authors examined, protein also present high percentage ileal carcinoids, bladder,...
Research Article| March 01, 2010 O- AND H-ISOTOPE RECORD OF CAPE TOWN RAINFALL FROM 1996 TO 2008, ITS APPLICATION RECHARGE STUDIES TABLE MOUNTAIN GROUNDWATER, SOUTH AFRICA C. HARRIS; HARRIS Department of Geological Sciences, University Cape Town 7701 South Africa e mail: chris.harris@uct.ac.za Search for other works by this author on: GSW Google Scholar BURGERS; BURGERS Africa, Present address: SRK Town, Albion Spring, 183 Main Rd, 7700 Rondebosch 7700, e-mail: clburgers@gmail.com J. MILLER;...
The Panzhihua intrusion in southwest China is part of the Emeishan Large Igneous Province and host a large Fe-Ti-V ore deposit. During emplacement main intrusion, multiple generations mafic dykes invaded carbonate wall rocks, producing contact aureole. We measured oxygen-isotope composition intrusions, their constituent minerals, samples country rock. Magnetite plagioclase from have δ18O values that are consistent with magmatic equilibrium, formed magmas were 1–2‰ higher than expected...
Abstract Endogenous c-MYC (MYC) has been reported to be a potential pharmacological target trigger ubiquitous tumor regression of pancreatic neuroendocrine tumors (PanNETs) and lung tumors. Recently inhibitors bromodomain extra-terminal (BET) family proteins have shown antitumor effects through the suppression MYC in leukemia lymphoma. In this paper, we investigated activity BET protein inhibitor (BETi) CPI203 as single agent combination with rapamycin human PanNETs. We found that exposure...
Abstract The magmatic-hydrothermal transition is key in controlling the fate of many economically important elements due to change partitioning when melt and magmatic fluid coexist. Despite its increasing economic importance, behavior lithium (Li) such environments remains poorly known. We illustrate how compositionally unusual biotites from rhyolitic Bishop Tuff (California, USA) Kos Plateau (Greece) may contain a volatile phase trapped between layers biotite crystals. originating pristine...