A5002545531- Heavy Metal Exposure and Toxicity
- Immunotoxicology and immune responses
- Vitamin K Research Studies
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Vitamin C and Antioxidants Research
- Trace Elements in Health
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Animal testing and alternatives
- Noise Effects and Management
- Clostridium difficile and Clostridium perfringens research
- Therapeutic Uses of Natural Elements
- Pharmacogenetics and Drug Metabolism
- Wound Healing and Treatments
- Contact Dermatitis and Allergies
- Antifungal resistance and susceptibility
- Viral Infections and Outbreaks Research
- Electrospun Nanofibers in Biomedical Applications
- Asthma and respiratory diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phagocytosis and Immune Regulation
- Pesticide Exposure and Toxicity
Western University
2022-2023
University of Belgrade
2013-2021
Institut de Biologie Valrose
2021
Inserm
2021
Université Côte d'Azur
2021
Centre National de la Recherche Scientifique
2021
Institute for Biological Sciences
2013-2014
Institute for Biological Research “Siniša Stanković”
2013-2014
Mucosa-associated invariant T (MAIT) cells are MR1-restricted, innate-like lymphocytes with tremendous antibacterial and immunomodulatory functions. Additionally, MAIT sense respond to viral infections in an MR1-independent fashion. However, whether they can be directly targeted immunization strategies against pathogens is unclear. We addressed this question multiple wild-type genetically altered but clinically relevant mouse strains using several vaccine platforms influenza viruses,...
The Wilms’ tumor suppressor Wt1 is involved in multiple developmental processes and adult tissue homeostasis. first phenotypes recognized knockout mice were cardiac kidney defects. expression the heart has been described epicardial, endothelial, smooth muscle cells, fibroblasts. Expression of cardiomyocytes suggested but remained a controversial issue, as well role cardiomyocyte development regeneration after injury. We determined during embryonic development, adult, injury by quantitative...
Although numerous investigations have demonstrated a direct effect of cadmium (Cd) on peripheral blood mononuclear cell (PBMC) activity in humans, there is virtually no data concerning the vivo impact this metal circulatory cells. In study, effects sub-lethal Cd (1 mg/kg) dose were examined rats 48 h following single intraperitoneal injection. treatment resulted increased total leukocyte levels; however, decreases PBMC numbers seen. These changes coincided with an accumulation cells lungs...
Summary Mucosa-associated invariant T (MAIT) cells are evolutionarily conserved, innate-like lymphocytes with enormous immunomodulatory potentials. Due to their strategic localization, cell receptor (iTCR) specificity for major histocompatibility complex-related protein 1 (MR1) ligands of commensal and pathogenic bacterial origin, sensitivity infection-elicited cytokines, MAIT best known antimicrobial characteristics. However, they thought also play important parts in the contexts cancer,...
Context: Dermal toxicity of coumarin anticoagulant rodenticides, such as warfarin, represents potential risk for workers handling these agents and individuals applying easily available rodenticides in their households well.Objective: In this study, proinflammatory effects repeated epicutaneous administration warfarin rats were explored by examining inflammatory cytokine skin responses.Materials methods: Ex vivo production IL-1β, IL-6, TNF-α IL-17 explants epidermal cells isolated enzyme...
Recombinant vesicular stomatitis virus (rVSV) vaccines expressing spike proteins of Wuhan, Beta, and/or Delta variants SARS-CoV-2 were generated and tested for induction antibody T cell immune responses following intramuscular delivery to mice. rVSV-Wuhan rVSV-Delta an rVSV-Trivalent (mixed rVSV-Wuhan, -Beta, -Delta) vaccine elicited potent neutralizing antibodies (nAbs) against live Wuhan (USAWA1), Beta (B.1.351), (B.1.617.2), Omicron (B.1.1.529) viruses. Prime-boost vaccination with...
Warfarin (WF) is an anticoagulant which also affects physiological processes other than hemostasis. Our previous investigations showed the effect of WF gained access to organism via skin on resting peripheral blood granulocytes. Based these data, aim present study was examine whether could modulate inflammatory as well. To this response induced by subcutaneous sponge implantation in rats examined.Warfarin-soaked polyvinyl sponges (WF-sponges) were implanted subcutaneously and cell...
Abstract Poly(DL‐lactide‐ co ‐ε‐caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition microstructure of characterized with Fourier transform infrared spectroscopy‐attenuated total reflection (FTIR‐ATR) scanning electron microscopy (SEM), respectively. Drug loading release properties investigated using methylene blue as the drug model. Biocompatibility...