A5081731382- Neuroscience of respiration and sleep
- Photorefractive and Nonlinear Optics
- Solid State Laser Technologies
- Glass properties and applications
- Renal function and acid-base balance
- Ion Transport and Channel Regulation
Vollum Institute
2024
Oregon Health & Science University
2024
Techtronic Industries (United States)
2002
Summary Acid-sensing ion channels (ASICs) are typically activated by acidic environments and contribute to nociception synaptic plasticity. ASIC1a is the most abundant subunit in central nervous system forms homomeric permeable Na + Ca 2+ , making it a compelling therapeutic target for acidotic pathologies including stroke traumatic brain injury. However, complete conformational library of human its various functional states has yet be described. Using cryo-EM, we obtained hASIC1a structures...
Thermoluminescence (TL), optical absorption, and electron paramagnetic resonance (EPR) have been used to characterize point defects in Mg-doped stoichiometric LiNbO3. A broad TL emission, peaking at 440 nm, is observed near 94 K when these crystals are irradiated 77 then rapidly warmed. X rays below-band-gap lasers (325 355 nm) equally effective producing the peak. During excitation, holes trapped on oxygen ions adjacent lithium vacancies electrons niobium regular lattice sites. These both...