A5080712003- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Animal Virus Infections Studies
- Virus-based gene therapy research
- interferon and immune responses
- Advanced Materials Characterization Techniques
- Software-Defined Networks and 5G
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Thermoregulation and physiological responses
- Thermochemical Biomass Conversion Processes
- Advanced Battery Technologies Research
- Advanced Photocatalysis Techniques
- Climate Change and Health Impacts
- Advanced MIMO Systems Optimization
- Electron and X-Ray Spectroscopy Techniques
- Cooperative Communication and Network Coding
- Coal Combustion and Slurry Processing
- Aluminum Alloys Composites Properties
- Viral Infections and Vectors
- Satellite Communication Systems
- Caching and Content Delivery
- Antibiotic Resistance in Bacteria
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Chinese Academy of Agricultural Sciences
2021-2025
Dalian Polytechnic University
2025
Zhejiang University
2013-2025
State Key Laboratory of Advanced Technology For Materials Synthesis and Processing
2025
Wuhan University of Technology
2025
Southern University of Science and Technology
2025
Nanjing University of Aeronautics and Astronautics
2024
Huazhong Agricultural University
2021-2024
New York University
2023-2024
“Thick electrode using high voltage cathode” can be considered, since this research focuses on cathode materials.
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has a global health crisis; its structural protein envelope (E) is critical for viral entry, budding, production, and induction of pathology which makes it potential target therapeutics against COVID-19. Here, we find that the E3 ligase RNF5 interacts with catalyzes ubiquitination E on 63rd lysine, leading to degradation ubiquitin-proteasome system (UPS). Importantly,...
Development of a multiplexed and sensitive biosensing platform is priority for public health security. We report micropore resistance counting based on polystyrene microsphere size-based encoding Clostridium butyricum Argonaute (CbAgo) decoding ultrasensitive detection. Initially, we constructed target DNA-modified coding system counting. Subsequently, the precise recognition cleavage capabilities guide DNA-activated CbAgo protein enable encoded system. Changes in concentration microspheres...
SARS-CoV-2, the causative agent of COVID-19 pandemic, undergoes continuous evolution, highlighting an urgent need for development novel antiviral therapies. Here we show a quantitative mass spectrometry-based succinylproteomics analysis SARS-CoV-2 infection in Caco-2 cells, revealing dramatic reshape succinylation on host and viral proteins. promotes several key enzymes TCA, leading to inhibition cellular metabolic pathways. We demonstrated that protein is regulated by nonstructural (NSP14)...
This paper presents the measurement of effective heat conductivity ash deposit based on a novel technique for Zhun Dong coal (ZD) with high sodium in pilot scale furnace. The variation thickness time is determined by digital image technique. In addition, simplified two color method applied to obtain surface temperature. Subsequently, change average growth calculated combining temperature and thickness. Meanwhile, mineral phases deposits were identified X-ray diffraction spectrometry (XRD);...
We report a highly efficient method to construct 3-trifluoromethyl coumarins using CF3SO2Cl as the trifluoromethyl radical source with ester 3-arylpropiolates. The reaction incorporated cascade cyclization/dearomatization/ester migration/oxidization/rearomatization process afford various under visible light irradiation in good excellent yields.
Abstract The severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne human-infecting bunyavirus, which utilizes two envelope glycoproteins, Gn and Gc, to enter host cells. However, the structure organization of these glycoproteins on virion surface are not yet known. Here we describe SFTSV determined by single particle reconstruction, allows mechanistic insights into bunyavirus assembly at near-atomic resolution. Gc proteins exist as heterodimers further assemble pentameric...
We developed an advanced microscopy imaging platform enabling amplification-free, multiplex detection of pathogenic bacteria in food and clinical samples, eliminating the need for DNA extraction. This leverages two-dimensional encoded polystyrene (PS) microspheres Argonaute-based decoding system to create multiplexed signal libraries. Each PS microsphere probe, with spectrally distinct fluorophores differing particle sizes, achieves high fluorescence through a tetrahedral DNA-enhanced...
Abstract The resolution capability of the scanning electron microscope has increased immensely in recent years, and is now within sub-nanometre range, at least for inorganic materials. An equivalent advance not yet been achieved imaging morphologies nanostructured organic materials, such as photovoltaic blends. Here we show that energy-selective secondary detection can be used to obtain high-contrast, material-specific images an blend. We also find differentiate mixed phases from pure...
Near infrared Cy dye was efficiently embedded into zeolitic imidazolate framework-8 by a facile route for further using in the imaging-guided photothermal therapy.
Emerging vaccine-breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlight an urgent need for novel antiviral therapies. Understanding the pathogenesis of coronaviruses is critical developing drugs. Here, we demonstrate that SARS-CoV-2 N protein suppresses interferon (IFN) responses by reducing early growth response gene-1 (EGR1) expression. The overexpression EGR1 inhibits replication promoting IFN-regulated expression, which interacts with and degrades...
Zhun Dong (ZD) coal, which is characterized by high sodium levels, was burned in a pilot-scale furnace to investigate the behavior of fouling deposits on an oil-cooled probe with different surface temperatures. In this study, were collected at 1298 K temperature. addition, inlet temperatures conduction oil set as 543, 493, and 443 K, comparable feedwater temperature coal-fired boiler economizer. The deposition varied ranges 733–594, 714–571, 671–507 K. A digital imaging technique used...
This study investigated the effects of high-intensity ultrasound (HIU, 95 W, 10 s) on physical properties, stability and in vitro digestion β-carotene enriched oleogels. Candelilla wax (3 wt%) nut oils (peanut, pine walnut oil) with or without were used to form HIU improved storage modules (G') peanut, oleogels from 11048.43 ± 728.85 Pa, 38111.67 11663.98 Pa 21921.13 1011.55 13502.40 646.54 75322.47 9715.25 48480.97 4109.64 respectively. Moreover, reduced oil loss 23.98 2.58%, 17.14 0.69%...