Philippe Charlier

ORCID: 0000-0003-0357-511X
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About
Contact & Profiles
Research Areas
  • Forensic Anthropology and Bioarchaeology Studies
  • Paleopathology and ancient diseases
  • History of Medicine Studies
  • Health, Medicine and Society
  • Autopsy Techniques and Outcomes
  • Forensic Entomology and Diptera Studies
  • Yersinia bacterium, plague, ectoparasites research
  • Historical Studies and Socio-cultural Analysis
  • Historical and Scientific Studies
  • Death, Funerary Practices, and Mourning
  • Health and Conflict Studies
  • Forensic and Genetic Research
  • Medical and Biological Sciences
  • Ethics in medical practice
  • Neurology and Historical Studies
  • Migration, Health and Trauma
  • Ethics in Clinical Research
  • Archaeology and ancient environmental studies
  • Empathy and Medical Education
  • Reproductive Health and Technologies
  • Aging, Elder Care, and Social Issues
  • Medical History and Research
  • Biomedical Ethics and Regulation
  • Medicine and Dermatology Studies History
  • Urological Disorders and Treatments

Université de Versailles Saint-Quentin-en-Yvelines
2016-2025

Hôpital Raymond-Poincaré
2007-2025

Institut de France
2020-2025

Université Paris-Saclay
2018-2025

Assistance Publique – Hôpitaux de Paris
2010-2025

Musée du Quai Branly – Jacques Chirac
2018-2024

Laboratoire Anthropologie, Archéologie, Biologie
2016-2024

Oxfam
2021

John Wiley & Sons (United States)
2021

Hudson Institute
2021

Although preventing excessive hyperglycemia during critical illness may provide clinical neuroprotection, it remains debated whether normoglycemia is without risk for the brain.To address this question, we compared neuropathological alterations in microglia, astrocytes, and neurons, with uncontrolled hyperglycemia, moderately controlled human illness. We further investigated time course an animal model.We analyzed brain specimens from patients who died intensive care unit critically ill...

10.1210/jc.2011-2971 article EN The Journal of Clinical Endocrinology & Metabolism 2012-03-23

The palace of King Ghezo in Abomey, capital the ancient kingdom Dahomey (present-day Benin), houses two sacred huts which are specific funerary structures. It is claimed that binder their walls made human blood. In study presented here, we conceived an original strategy to analyze proteins present on minute amounts cladding sampled from inner facade cenotaph wall and establish origin. extracted were proteolyzed resulting peptides characterized by high-resolution tandem mass spectrometry....

10.1002/pmic.202400048 article EN cc-by-nc-nd PROTEOMICS 2024-05-29

The forensic community does not agree on the need to perform histological examination at autopsy. aim of our study was determine usefulness systematic standard histology in autopsies. A prospective carried out 428 autopsy cases for which systematic. Mechanism death shown by gross anatomic findings discovered about 40% cases. Cause established only 8.4% Microscopic affected manner 13% Histology provided complementary information prior medical condition deceased 49% Traumatic lesions were...

10.1111/j.1556-4029.2009.01240.x article EN Journal of Forensic Sciences 2009-12-02

The French revolutionary Jean-Paul Marat (1743–1793) was assassinated in 1793 his bathtub, where he trying to find relief from the debilitating skin disease suffering from. At time of death, annotating newspapers, which got stained with blood and were subsequently preserved by sister. We extracted sequenced DNA stain also another section newspaper, we used for comparison. Results human sequence analyses compatible a heterogeneous ancestry Marat, mother being origin father born Sardinia....

10.1016/j.meegid.2020.104209 article EN cc-by-nc-nd Infection Genetics and Evolution 2020-01-29

Anthropological and palaeopathological examination of four male skeletons from Qumran (Near-East) revealed skeletal lesions that may be linked to an intense practice traditional Jewish rituals within this hyper-religious community the first-century CE: chronic inflammation external auditory canals frequent immersion in sacred baths (mikvah), osteo-articular following repeated genuflection anteflexion trunk.

10.1007/s10943-024-02230-1 article EN cc-by Journal of Religion and Health 2025-01-15

10.1016/j.jemep.2025.101056 article EN Ethics Medicine and Public Health 2025-01-01

10.1016/j.jemep.2025.101077 article EN Ethics Medicine and Public Health 2025-01-01

Abstract Ancient DNA provides a unique opportunity to study the history and spread of infectious diseases. Here, we analyzed 21 samples from collection 20th-century penis gourds (koteka) Papua New Guinea housed at Musée du quai Branly – Jacques Chirac in Paris. Despite presence environmental species, identified human-associated bacteria and, notably, an Epstein-Barr Virus (EBV) genome high coverage. Phylogenetic analysis placed this strain within Guinea–Indonesian cluster. These findings...

10.1093/infdis/jiaf189 article EN The Journal of Infectious Diseases 2025-04-09

10.1016/j.jemep.2025.101096 article EN Ethics Medicine and Public Health 2025-01-01

10.3917/sh.378.0056 article CA Sciences Humaines 2025-04-22

During the Middle Ages, partition of cadaver elite members was a current practice, with highly technical treatment given to symbolic organs such as heart. Considered mostly from theoretical point view, this notion dilaceratio corporis has never been biologically explored. To assess exact kind embalming reserved heart, we performed full biomedical analysis mummified heart English King Richard I (1199 A.D.). Here show among other aspects, that organ embalmed using substances inspired by...

10.1038/srep01296 article EN cc-by-nc-nd Scientific Reports 2013-02-28

ABSTRACT Intentional cranial deformations (ICD) have been observed worldwide but are especially prevalent in preColombian cultures. The purpose of this study was to assess the consequences ICD on three cavities (intracranial cavity, orbits, and maxillary sinuses) vault thickness, order screen for morphological changes due external constraints exerted by deformation device. We acquired CT‐scans 39 deformed 19 control skulls. studied thickness skull using qualitative quantitative methods....

10.1002/ajpa.22263 article EN American Journal of Physical Anthropology 2013-03-29

Abstract Naturally preserved and embalmed bodies from archeological contexts represent a powerful source of information for forensic investigators. They allow one to ascertain pathology, cause death, enhance diagnostic methodology, improve the analysis altered remains. We investigated complete head lung remnants 3,500‐year‐old Egyptian dignitary by radiological, microscopic, genetic approaches. The individual, middle‐aged male, suffered severe periodontitis, mild atherosclerosis, experienced...

10.1111/1556-4029.13138 article EN Journal of Forensic Sciences 2016-06-30

Scientific examination of the heart Blessed Pauline Jaricot-a French missionary figure-was carried out in 2022. As tandem mass spectrometry proteotyping has proven to be valuable obtain broad taxonomic repertoire a given sample without any priori information, we aimed at exploring conditions preservation relics and possible death. Metaproteomics high-resolution microtomography imaging approaches were combined. A dataset comprising 6731 MS/MS spectra was acquired 968 these could assigned...

10.3390/ijms24033011 article EN International Journal of Molecular Sciences 2023-02-03
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