A5040639227- Biosimilars and Bioanalytical Methods
- PARP inhibition in cancer therapy
- Prostate Cancer Treatment and Research
- Lipoproteins and Cardiovascular Health
- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- Pesticide Residue Analysis and Safety
- Analytical Methods in Pharmaceuticals
- Clinical Laboratory Practices and Quality Control
- Advanced Biosensing Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Statistical Methods in Clinical Trials
- Cell Image Analysis Techniques
- Protein purification and stability
- Radiopharmaceutical Chemistry and Applications
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Cholesterol and Lipid Metabolism
- Wildlife-Road Interactions and Conservation
- Inflammation biomarkers and pathways
- Genetics, Bioinformatics, and Biomedical Research
- Receptor Mechanisms and Signaling
- Cancer Genomics and Diagnostics
- Actinomycetales infections and treatment
- Analytical Chemistry and Chromatography
All India Institute of Medical Sciences Raipur
2024
Janssen (United States)
2013-2024
Springhouse
2013-2024
Johnson & Johnson (United States)
2018-2024
University of Alabama at Birmingham
2023-2024
College of Medical Sciences
2023
Smt. N.H.L. Municipal Medical College
2021-2023
B.J. Medical College
2023
Creative Commons
2023
Janssen (Belgium)
2014-2022
The 2013 7th Workshop on Recent Issues in Bioanalysis was held Long Beach, California, USA, where close to 500 professionals from pharmaceutical and biopharmaceutical companies, CROs regulatory agencies convened discuss current topics of interest bioanalysis. These 'hot' topics, which covered both small large molecules, were the starting point for fruitful exchanges knowledge, sharing ideas among speakers, panelists attendees. discussions led specific recommendations pertinent bioanalytical...
Advances in the technologies to enable patient-centric sampling (PCS) have potential improve blood sample collection by enabling clinical trial participants collect samples via self-collection or with help of a caregiver their home. Typically, assess pharmacokinetics and pharmacodynamics drug during development are collected at site venous draw. In this position paper International Consortium for Innovation Quality Pharmaceutical Development (IQ), value PCS can bring patients, datasets...
The 2014 8th Workshop on Recent Issues in Bioanalysis (8th WRIB), a 5-day full immersion the evolving field of bioanalysis, took place Universal City, California, USA. Close to 500 professionals from pharmaceutical and biopharmaceutical companies, contract research organizations regulatory agencies worldwide convened share, review, discuss agree approaches address current issues interest bioanalysis. topics covered included both small large molecules, involved LCMS, hybrid LBA/LCMS, LBA...
The 2014 8th Workshop on Recent Issues in Bioanalysis (8th WRIB), a 5-day full immersion the evolving field of bioanalysis, took place Universal City, California, USA. Close to 500 professionals from pharmaceutical and biopharmaceutical companies, contract research organizations regulatory agencies worldwide convened share, review, discuss agree approaches address current issues interest bioanalysis. topics covered included both small large molecules, involved LCMS, hybrid LBA/LCMS, LBA...
There is continuing interest in the development and application of various microsampling technologies for drug development. The AAPS bioanalytical community subgroup European Bioanalysis Forum conducted a survey their members (39 individual organizations). This gives snapshot current practices demonstrates that implementation approaches becoming increasingly commonplace, but not universal. Greater adoption was observed nonclinical studies, particularly nonregulatory. A number respondents...
Selective cyclooxygenase (COX)-2 inhibitors have been extensively studied for colorectal cancer (CRC) chemoprevention. Celecoxib has reported to reduce the incidence of adenomas and CRC but is also associated with an increased risk cardiovascular events. Here, we report a series gut-restricted, selective COX-2 characterized by high colonic exposure minimized systemic exposure. By establishing acute ex vivo 18F-FDG uptake attenuation as efficacy proxy, identified subset analogues that...
A sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method coupled with dansylation was developed for the simultaneous quantification of exogenously administered deuterated 17beta-estradiol-d4 (E2-d4) and its metabolite, estrone-d4 (E1-d4), in mouse plasma brain homogenates. The reaction simple, fast, sensitive, a lower limit 50 pg/mL achieved by using microL plasma. Interference from endogenous 17beta-estradiol estrone samples minimized use deuterated-E2 as well utilizing...
An interference leached from polypropylene tubes was identified to be a sulfoxide oxidative product of didodecyl 3,3'-thiodipropionate (DDTDP) that is used prevent degradation synthetic polymers. A sulfone DDTDP the also observed. The interfering compounds were isolated by LC and characterized using time-of-flight mass spectrometry NMR. Authentic products prepared reacting with hydrogen peroxide reaching an unequivocal structural assignment. In conclusion, when analytes interest are...
Bioanalysis Zone carried out a survey to evaluate the use of and attitudes DBS analysis among our readership in bioanalytical community. has generated huge amount interest recent years. We wanted take snapshot field determine whether consensus is emerging on future DBS. asked you for your honest opinions delivered! You can view full results at www.bioanalysis-zone.com. have selection short opinion articles below, giving range viewpoints current DBS, alongside some results.
The purpose of the study was to assess amount serum copper, zinc, and copper-to-zinc ratio in sickle cell anemia patients healthy subjects relate parameters with an objective disease severity score. Further, see correlation between copper zinc levels fetal hemoglobin level (SCA) both stable state during crisis.
Abstract STING (Stimulator of Interferon Genes) is an important mediator innate and adaptive immunity that responds to invading cytosolic bacterial viral pathogens, double stranded DNA from transformed cells. Activation the cGAS-STING pathway leads pleiotropic cytokine (IFN-α, IFN-β, TNF-α, IL-6) production, maturation activation macrophages, MHC class II expressing dendritic cells (DCs) with generation CD8+ T JNJ-67544412 (JNJ-4412) a cyclic dinucleotide (CDN) developed as agonist. JNJ-4412...
Abstract The Stimulator of Interferon Genes (STING) protein is a key mediator innate immunity that plays central role in the immune response to invading pathogens (bacterial, viral) and transformed cells. A next generation human STING agonist, JNJ-‘6196 was developed cures mice their tumors preclinical models when administered by IV route. rationally selected have weaker binding affinity fast off rate but functionally strong cytokine inducer an efficient activator dendritic exhibits unique...
Abstract Patients with prostate cancer whose tumors bear deleterious mutations in DNA-repair pathways often respond to PARP inhibitors. Studies were conducted compare the activity of several inhibitors vitro and their tissue exposure vivo efficacy mice bearing PC-3M-luc-C6 grown subcutaneously or bone. Niraparib, olaparib, rucaparib, talazoparib compared proliferation assays, using tumor cell lines a cell-free PARP-trapping assay. cells approximately 12- 20-fold more sensitive inhibition...
Historically patients with severely depressed or elevated white blood cell (WBC) counts during infection were felt to have worse outcomes. To test this assumption we prospectively analyzed all infections on the surgical services at University of Virginia hospital between December 1, 1996 and April 1999. Among 1737 infectious episodes 59 presented leukopenia (WBC count < = 3,000 cells/microL) whereas 66 leukemoid responses > 30,000 cells/microL). Compared other infected leukopenic had higher...