A5052108006- Drug Solubulity and Delivery Systems
- Nanocomposite Films for Food Packaging
- Advanced Drug Delivery Systems
- Antimicrobial agents and applications
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Curcumin's Biomedical Applications
- Advancements in Transdermal Drug Delivery
- Antimicrobial Peptides and Activities
- Click Chemistry and Applications
- biodegradable polymer synthesis and properties
- Pineapple and bromelain studies
- Polydiacetylene-based materials and applications
- Protein purification and stability
- Advanced biosensing and bioanalysis techniques
- Porphyrin and Phthalocyanine Chemistry
- Chemical Synthesis and Analysis
- Surfactants and Colloidal Systems
- Polymer Surface Interaction Studies
- Analytical Methods in Pharmaceuticals
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Biopolymer Synthesis and Applications
- Ocular Surface and Contact Lens
- Photodynamic Therapy Research Studies
University of Iceland
2015-2024
Physiol (Belgium)
2019
University of Utah
2019
Fundação para a Ciência e Tecnologia
2019
Pharmaceutical Biotechnology (Czechia)
2015-2016
RMIT University
2010-2013
National University Hospital of Iceland
2003
Tokyo Institute of Technology
1999
University of Copenhagen
1990-1993
Ørsted (Denmark)
1990-1993
Polysaccharides are among the most abundant bioresources on earth and consequently need to play a pivotal role when addressing existential scientific challenges like climate change shift from fossil-based sustainable biobased materials. The Research Roadmap 2040 of European Polysaccharide Network Excellence (EPNOE) provides an expert's view how future research development strategies evolve fully exploit vast potential polysaccharides as renewable bioresources. It is addressed academic...
A series of soft quaternary ammonium antimicrobial agents, which are analogues to currently used preservatives such as cetyl pyridinium chloride and benzalkonium chloride, were synthesized. These consist long alkyl chain connected a polar headgroup via chemically labile spacer group. They characterized by facile nonenzymatic enzymatic degradation form their original nontoxic building blocks. However, chemical stability has be adequate in order for them have effects. Stability studies...
A highly efficient method for chemical modification of chitosan biopolymers by reductive amination to yield N,N-dialkyl derivatives was developed. The use 3,6-O-di-tert-butyldimethylsilylchitosan as a precursor enabled the first 100% disubstitution amino groups with long alkyl chains. corresponding mono N-alkyl were also synthesized, and all compounds then quaternized using an optimized procedure. These well-defined studied antibacterial activity against Gram positive S. aureus, E. faecalis,...
A series of water-soluble cationic chitosan derivatives were prepared by chemoselective functionalization at the amino group five different parent chitosans having varying degrees acetylation and molecular weight. The quaternary moieties introduced alkyl spacer lengths from polymer backbone (C-0, C-2 C-6) with aid 3,6-di-O-tert-butyldimethylsilyl protection backbone, thus allowing full (100%) substitution free groups. All characterized using 1H-NMR, 1H-1H COSY FT-IR spectroscopy, while...
Grafting of anoplin to chitosan polymers in varying density and orientation leads a 30-fold activity enhancement reduction toxicity towards red blood cell more than two orders magnitude.
Curcumin is the main constituent of curry. In its ground state it shows chemo-preventive, chemo-therapeutic and anti-inflammatory effects. For immunostimulating action has been considered for development drugs suitable treating AIDS cystic fibrosis. Further biological induced in curcumin by photoactivation: environmental conditions electronically excited can act as a singlet oxygen generator. Moreover, cytotoxicity enhanced light exposure antibacterial effects are photosensitized. This work...
In this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ). The NPs are based on chitosan (CS) conjugate polymers synthesized with different amounts of photosensitizer tetraphenylchlorin (TPC). These TPC–CS high loading capacity and strong drug retention due to π–π stacking interactions between aromatic groups polymers. CS 10% side chains TPC were found be optimal in terms NP stability. loaded MRT CBZ...
We have studied the effect of chitosan sponges, produced from batches with distinct degree deacetylation (DDA) and molecular weight (Mw), on adhesion, growth differentiation primary human osteoblasts an aim to offer a suitable tool for guided bone regeneration. All sponges revealed similar microstructure, irrespective DDA (58, 73, 82, 88, 91 %) Mw (749, 547, 263, 215, 170 kDa, respectively). Cell spreading was higher having DDA. Higher induced more pronounced increase in alkaline phosphatase...