A5045665079- Bone Tissue Engineering Materials
- Proteoglycans and glycosaminoglycans research
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Periodontal Regeneration and Treatments
- Collagen: Extraction and Characterization
- Electrospun Nanofibers in Biomedical Applications
- Titanium Alloys Microstructure and Properties
- Connective tissue disorders research
- Osteoarthritis Treatment and Mechanisms
- Dental materials and restorations
- Bone Metabolism and Diseases
- Cell Adhesion Molecules Research
- Corrosion Behavior and Inhibition
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- Bone and Dental Protein Studies
- Wound Healing and Treatments
- Bone health and osteoporosis research
- Bone health and treatments
- biodegradable polymer synthesis and properties
- RNA Interference and Gene Delivery
- Hydrogen embrittlement and corrosion behaviors in metals
Technische Universität Dresden
2013-2022
Max Bergmann Zentrum für Biomaterialien
2013-2022
Berlin-Brandenburger Centrum für Regenerative Therapien
2012-2020
Leibniz Institute for Solid State and Materials Research
2006-2017
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
2014
Leipzig University
2001-2014
Helmholtz-Zentrum Dresden-Rossendorf
1992-1993
Goethe University Frankfurt
1970-1971
The initial contact of osteoblasts with implant surfaces is an important event for osseointegration implants. Osseointegration Ti6Al4V may be improved by precoating its surface collagen type I. In this study, the adhesion rat calvarial to uncoated and I-coated titanium alloy was investigated over a period 24 h. Collagen I-coating accelerates in presence fetal calf serum. One hour after plating, no differences percentage adherent cells between were found. Adhesion reduced GRGDSP peptide about...
Collagen has found use as a scaffold material for tissue engineering well coating implants with view to enhancing osseointegration through mimicry of the bone extracellular matrix in vivo. The aim this study was compare collagen types I, II, and III regard their ability bind small leucine-rich proteoglycans (SLRPs) decorin biglycan during fibrillogenesis vitro phosphate buffer. In addition, influence SLRPs on proportion molecules incorporated into fibrils at high low ionic strength...
The influences of physical stimuli such as surface elasticity, topography, and chemistry over mesenchymal stem cell proliferation differentiation are well investigated. In this context, a fundamentally different approach was adopted, we have demonstrated the interplay inherent substrate conductivity, defined chemical composition cellular microenvironment, intermittent delivery electric pulses to drive toward osteogenesis. For this, conducting polyaniline (PANI) substrates were coated with...
Abstract: The aim of the present study was to analyse effect organic coating titanium implants on periimplant bone formation and bone/implant contact. Three types were used: (i) Ti6Al4V with polished surface (control 1) (ii) collagen 2) (iii) covalently bound RGD peptides. All had square cross‐sections an oblique diameter 4.6 mm inserted press fit into trephine burr holes in mandibles 10 beagle dogs. five animals each evaluated after a healing period 1 month 3 months, during which sequential...
Abstract The aim of the present study was to test hypothesis that organic coating titanium screw implants provides binding sites for integrin receptors can enhance periimplant bone formation. Ten adult female foxhounds received experimental in mandible 3 months after removal all premolar teeth. Four types were evaluated each animal: (1) with machined surface, (2) coated collagen I, (3) I and cyclic RGD peptide (Arg‐Gly‐Asp) low concentrations (100 μmol/mL), (4) high (1000 μmol/mL)....
Abstract: The aim of the present study was to test hypothesis that immobilization bone morphogenic protein (BMP2) on surface titanium implants can enhance peri‐implant formation. Ten adult female foxhounds received experimental screw in mandible 3 months after removal all premolar teeth. Three types implant surfaces were evaluated each animal: (i) with machined surface, (ii) coated collagen I, (iii) chondroitin sulphate (CS) and BMP2. Peri‐implant regeneration assessed using histomorphometry...
Abstract An electrochemical method for the deposition of calcium phosphate phases on titanium surfaces using galvanostatic mode is presented. Deposition was performed in a (Ca 2+ /H x PO 4 (3− )− )‐containing electrolyte near physiological conditions with regard to pH (6.4) and temperature (36°C). Cathodic alkalization leads first formation thin homogeneous layer that shows nanoscale surface topography alternating wall‐like elevations channels. It thought these channels prelayer are formed...
Type-I collagen, the major structural protein in bone, has beneficial properties regarding bone regeneration. Little is known about potential effects of collagen coating on orthopedic implants.3 to 6 microg/cm2 lyophilized type-I was absorbed titanium rods. Six coated and uncoated pins 0.9 mm diameter were inserted into tibia adult male Wistar rats for 1, 2, 4, 7, 14, 28 days. Specimens embedded methacrylate-based Technovit 9100N resin. From one portion cutting grinding sections obtained....
In this study, we have demonstrated that the modification of hyaluronan (hyaluronic acid; Hya) with sulfate groups led to different binding affinities for recombinant human bone morphogenetic protein-4 (rhBMP-4). The high-sulfated sHya2.8 (average degree sulfation (D.S.) 2.8) exhibited tightest interaction rhBMP-4, followed by low-sulfated sHya1.0, as determined surface plasmon resonance (SPR), ELISA, and competition ELISA. Unmodified Hya, chondroitin-sulfate (CS), heparan (HS) showed...
Dental implant materials serve a variety of purposes. The majority them are used as intraosseous appliances in the jaw bones for permanent anchorage tissue integrated prostheses. Successful clinical use these is based on integration into adjacent bone tissue. Compromised conditions and periimplant defects can impair this interaction require enhancement osteogenesis to accomplish desired level contact. Established techniques modifications surface morphology inorganic chemistry. Advanced...