A5109909474- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Musculoskeletal synovial abnormalities and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune and Inflammatory Disorders Research
- Viral Infections and Immunology Research
- Platelet Disorders and Treatments
- T-cell and B-cell Immunology
- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Geotechnical Engineering and Soil Mechanics
- Sphingolipid Metabolism and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Vibration Control and Rheological Fluids
- Kawasaki Disease and Coronary Complications
- Ocular Diseases and Behçet’s Syndrome
- Immunodeficiency and Autoimmune Disorders
- Engineering Applied Research
- Proteoglycans and glycosaminoglycans research
- Atherosclerosis and Cardiovascular Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Geotechnical Engineering and Underground Structures
- Immunotherapy and Immune Responses
- Drug-Induced Ocular Toxicity
- Otitis Media and Relapsing Polychondritis
Juntendo University
2011-2025
Murayama Medical Center
2023
Nippon Steel (Japan)
2019
Tokyo Institute of Technology
2008
Abstract Objective: Recent SLE guidelines recommend using HCQ at < 5.0 mg/kg/day to reduce retinopathy risk but note that doses below this may increase flare risk, suggesting as ideal. Evidence is insufficient, especially among Japanese. Method: We retrospectively analyzed 321 patients treated with Juntendo University Hospital between December 2015 and March 2019. They were divided into a low-dose group (< 5 mg/kg /day, n = 205) high-dose (≥ 116). This study compared side...
Abstract Objectives Recent guidelines and recommendations for lupus nephritis (LN) suggest rapid glucocorticoid (GC) reduction; however, robust supporting evidence remains limited. This study aimed to evaluate the impact of GC reduction on renal outcomes in patients with proliferative LN. Methods We conducted a multicentre retrospective chart review GC-naïve, biopsy-proven LN available urinary protein-to-creatinine ratio (UPCR) data before 52 weeks after treatment. Patients who reduced their...
Objective: Systemic lupus erythematosus (SLE) is characterized by loss of B cell tolerance and the presence polyclonal activation. Syndecan-1 (CD138) expressed on plasma cells derived from cells, suspected to play a role in SLE. We evaluated level soluble CD138 (sCD138) surface expression patients with active SLE, also examined correlations among serum levels BAFF, proliferation-inducing ligand (APRIL), these patients.
To determine the degree of contribution and contributing factors ultrasound in diagnosis rheumatoid arthritis (RA) daily clinical practice predictive differences depending on seropositivity.We included 122 patients who presented with main complaint finger and/or wrist joint pain but for whom no definite was reached or treatment strategy provided. Ultrasound performed at least 22 joints (both joints, proximal interphalangeal joint, metacarpophalangeal joints), were followed ≥6 months. Factors...
To clarify the clinical features of systemic lupus erythematosus (SLE) patients, factors associated with flares, and changes over time.Patients having SLE a visiting history were entered into Juntendo University Database Erythematosus. We included 423 cases in long-term follow-up analysis, 383 followed for 10 years after initiation any therapeutic intervention (comparative analysis: 1973-1982, 82 cases; 1983-1992, 141, 1993-2002, 160). assessed patients' background characteristics, disease...
Journal Article Predictive value of bone destruction and duration clinical remission for subclinical synovitis in rheumatoid arthritis patients Get access Nao Tokai, Tokai Department Internal Medicine (I), Osaka Medical College Search other works by this author on: Oxford Academic Google Scholar Michihiro Ogasawara, Ogasawara Rheumatology, Juntendo University Faculty Medicine, Tokyo 113-8431, Japan Correspondence to: Dr. 2-1-1 Hongo, Bunkyo-ku, 113-8421, Japan. Tel: + 81-3-5802-1067. Fax:...
Objective. To determine whether weighting improves the correlation of ultrasound (US) score with serum matrix metalloproteinase-3 (MMP-3) level in rheumatoid arthritis (RA). Methods. As examination was performed on 100 RA patients, and severity synovial effusion hypertrophy blood flow were semi-quantitatively graded from 0 to 3 by using gray-scale (GS) power Doppler (PD) modes. We then calculated sums scores 28 joints each patient 2 modes, that is, GS28 PD28 scores, as well respective...
B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are known to be crucial for maturation survival, increased expression of these factors in various autoimmune diseases has been reported. Human cells produce two IgA subclasses: IgA1 IgA2, the latter being abundant distal intestine, saliva, colostrum bronchial fluid. We investigated parameters patients with mixed connective tissue disease (MCTD) complicated by interstitial lung (ILD+), compared them those MCTD without...
Nonlinear soil properties as well bedrock outcrop strong motions are back-calculated using 4-depth downhole recorded at the Kashiwazaki-Kariwa nuclear power plant during 2007 Niigata-ken Chuetsu-oki earthquake. Adopted in inverse analysis genetic algorithms (GA) combined with a 1-D equivalent-linear response which strain-dependent damping ratios assumed frequency domain. The inversion results show that surface layer down to depth of 70 m exhibited nonlinear behavior shear modulus ratio about...
ニューモシスシス肺炎(Pneumocystis pneumonia;以下PCP)を併発した自験20例の膠原病患者の臨床データを解析し,厚生労働省研究班のST合剤の予防投与基準の有用性について検証した.19例(95%)は間質性肺炎(Interstitial...
To determine which grade of ultrasound (US) synovitis corresponds to clinically involved joints in rheumatoid arthritis (RA) and develops a new US-adjusted composite measure.Clinical US examinations were performed on 137 patients with RA (28 joints). Synovial effusion, hypertrophy, blood flow semiquantitatively graded from 0 3 using gray scale (GS) power Doppler (PD) modes. We calculated simple disease activity index (SDAI) assessed feasibility, external validity by comparing erythrocyte...
<h3>Background</h3> In SLE, immune complexes are overproduced and deposited in tissues where they ultimately cause damage. The immunocomplexes, which the myocardium, blood vessels atrioventricular valves, have been suggested to damage relevant tissues, but it remains unclear cases tissue progresses a point that surgical treatment is required. <h3>Objectives</h3> purpose of our study was classify heart diseases into valvular (V), ischemic (I) aortic aneurysms (A), compare each class terms...
Hydroxychloroquine (HCQ) has been positioned as an anchor drug for systemic lupus erythematosus (SLE). There is evidence supporting the benefits of HCQ; however, effect additional HCQ in maintenance therapy remains unclear.Thirty patients with SLE who visited Juntendo University Hospital were receiving before treatment and able to complete more than 104 weeks analyzed. Anti-DNA antibody titers, IgG CH50 levels, dose corticosteroids, disease activity index (SLEDAI), achievement Lupus Low...
A 40-year-old man who was diagnosed with bronchial asthma and eosinophilia transferred to our hospital due a worsening respiratory status. He eosinophilic granulomatosis polyangiitis (EGPA), pneumoniae. Cardiac magnetic resonance (CMR) imaging indicated Löffler endocarditis. Treatment initiated using intravenous methylprednisolone, cyclophosphamide, heparin as anticoagulation therapy. Three months later, CMR showed the improvement of LV myocardium.
A friction damper is one of useful displacement-depending energy dissipation devices; however, it necessary to obtain the mechanical characteristics each material through various experiments. Also conventional design methods obtaining optimal stiffness distribution adjust response story drift angle target values inconvenient for dampers. In this paper, dynamic loading tests dampers with different kinds materials are conducted, and compared. Further, an alternative method response-controlled...
Abstract Background Rheumatoid arthritis (RA) is characterized by persistent synovitis, which evaluated using ultrasound. Ultrasound-based global assessment of the joints correlated with serum cytokine levels. This correlation was validated in cross-sectional but not prospective studies. We aimed to verify this validity a study RA patients treated interleukin (IL)-6 receptor inhibitor tocilizumab. Methods Twenty-four consecutive started on tocilizumab treatment were prospectively enrolled....