A5059030052- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cystic Fibrosis Research Advances
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Parvovirus B19 Infection Studies
- Immune responses and vaccinations
- Cell Adhesion Molecules Research
- NF-κB Signaling Pathways
- Diabetes and associated disorders
- Prenatal Screening and Diagnostics
- Legionella and Acanthamoeba research
- TGF-β signaling in diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Lymphocytic Leukemia Research
- Platelet Disorders and Treatments
- Cholesterol and Lipid Metabolism
- Connective Tissue Growth Factor Research
- Liver physiology and pathology
- Neurogenetic and Muscular Disorders Research
- Gastrointestinal disorders and treatments
Cairo University
2014-2024
The prevalence of childhood infection with Helicobacter pylori is high, especially in developing countries. Non-invasive methods for detection children should be inexpensive, easy to perform, well tolerated and have a high diagnostic accuracy. We aimed compare the reliability, specificity sensitivity H. stool antigen (HpSA) test 13C-urea breath (13C-UBT) diagnosis limited resource setting.The samples 60 symptomatic dyspeptic mean age 7.2 ±3.7 years (2-15 years) were evaluated using rapid One...
Abstract Background Caspase recruitment domain family, member 11 (CARD11) is an important protein which plays a fundamental role in the activation of NF-κβ pathway lymphocytes. CARD11 deficiency can be inherited either autosomal dominant or recessive forms and present with different phenotypes including combined immunodeficiency, atopic dermatitis, other variable manifestations. The report describes clinical immunological defects two unrelated patients missense homozygous variants presenting...
ABSTRACT Objectives To present the current status of prenatal diagnosis services and results from largest thalassaemia center in Egypt treating 3000 patients. Traditionally, has not been successful reducing births affected children Egypt, because majority women undergoing continued to have pregnancies. Methods Seventy‐one pregnant mothers at risk for β‐thalassaemia underwent by chorionic villus sampling ( n = 57) or amniocentesis 14) between 11 14 weeks gestation. Molecular characterization...
Summary Mutations affecting recombination activation genes RAG1 and RAG2 are associated with variable phenotypes, depending on the residual recombinase activity. The aim of this study is to describe a variety clinical phenotypes in RAG-deficient patients from highly consanguineous Egyptian population. Thirty-one RAG mutations (from 28 families) were included 2013 2017. On basis clinical, immunological genetic data, subdivided into three groups; classical T–B– severe combined immunodeficiency...
One consequence of hepatitis C virus (HCV) infection is an elevated cancer risk. During chronic viral infection, deoxyribonucleic acid (DNA) damage being induced by reactive oxygen and nitrogen species, which may play a pathogenic role in HCV-induced carcinogenesis. The study investigated DNA peripheral blood lymphocytes from patients with hepatocellular carcinoma (HCC) those HCV without associated cirrhosis normal controls. As measure for genomic damage, the comet assay (single cell gel...
Background: DNA methylation is an epigenetic process that refers to chromatin-based mechanisms in the regulation of gene expression without alternation. It mediated by methyltransferases (DNMTs). The methyltransferase 3B (DNMT3B) contains a C-to-T single nucleotide polymorphism (SNP; rs2424913) Promotor region, 149 base pairs from transcription start site, which reported significantly increase activity. Objective: To investigate prevalance rs2424913 located DNMT3B Promotor. Methods: In...
Human inborn errors of immunity (IEI) are a group inherited genetic disorders the immune system. IEI Patients suffer from severe repeated infections, autoimmunity, lymphadenopathy and/or increased susceptibility to malignancies. due absence, disproportion, or loss function cells; mostly in autosomal recessive manner, hence more common countries with high rate consanguinity. Definite diagnosis is achieved by analysis, however it not always available.to report on different categories and...
Hepatitis C virus (HCV) is a major cause of chronic liver disease in Egypt, leading to hepatic fibrosis, cirrhosis (LC), and hepatocellular carcinoma (HCC). Liver fibrosis characterized by excessive deposition extracellular matrix (ECM). Newly-recognized pathogenic mechanisms point the epithelial-mesenchymal transition (EMT) hepatocytes synthesizing (myo-) fibroblasts. Transforming growth factor-beta (TGF-β1), bone morphogenic protein (BMP)-7, connective tissue factor (CTGF) are biomarkers...
Primary immunodeficiency (PID) patients are prone to developing viral infections and should not be vaccinated with live vaccines. In such patients, prolonged excretion divergence may occur they subsequently act as reservoirs in the community introducing mutated virus jeopardizing polio eradication. One hundred thirty PID cases were included for poliovirus detection stool assessment of detected polioviruses from oral vaccine (OPV) virus. Clinical presentations detectable specimens...
Liver transplant is the cornerstone line of treatment for chronic liver diseases; however, long list complications and obstacles stand against this operation. Searching new modalities illness a must. In present research, we aimed to compare effects undifferentiated human mesenchymal stem cells, in vitro differentiated adult hepatocytes an experimental model failure.Undifferentiated cord blood cells were isolated, pro-pagated, characterized by morphology, gene expression analysis, flow...
Summary Severe combined immunodeficiency (SCID) is fatal if not treated with immune reconstitution. In Egypt, T-B+ SCID accounts for 38·5% of diagnoses. An accurate genetic diagnosis essential choosing appropriate treatment modalities and offering counseling to the patient's family. The objectives this study were describe clinical, immunological molecular characteristics a cohort twenty Egyptian patients SCID. initial (based on clinical features flow cytometry) was followed by investigation...
Abstract Background Purine nucleoside phosphorylase (PNP) deficiency is a rare, autosomal recessive, inborn error of immunity. It characterized by progressive immune abnormalities ranging from severe combined immunodeficiency (SCID) to less profound than SCID, neurological and autoimmunity. Early detection diagnosis before the development life-threatening complications are crucial. Methods Immune cell subsets were assessed flow cytometry, serum immunoglobulins uric acid levels evaluated,...
The existence of multiple autoimmune disorders in diabetics may indicate underlying primary defects immune regulation. study aims at estimation CD4(+) CD25(+high) cells among diabetic children with manifestations, and identification disease characteristics those children. Twenty-two cases type 1 diabetes associated other diseases were recruited from the Diabetic Endocrine Metabolic Pediatric Unit (DEMPU), Cairo University along twenty-one normal subjects matched for age sex as a control...
Abstract Background Novel direct-acting antiviral agents have shown great efficacy and tolerability in HCV-monoinfected patients. However, data are lacking regarding their safety HIV/HCV-genotype (GT) 4-coinfected Methods A single-centre, prospective study including HIV/HCV-GT patients who were treated with sofosbuvir daclatasvir (SOF/DCV) was conducted for 12 wk. Sustained virological response (SVR) at week post-treatment (SVR12), adverse events (AEs) changes liver stiffness measurement...