A5054251763- HIV/AIDS drug development and treatment
- Influenza Virus Research Studies
- Computational Drug Discovery Methods
- Malaria Research and Control
- Fungal and yeast genetics research
- RNA and protein synthesis mechanisms
- HIV Research and Treatment
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Hepatitis C virus research
- Viral Infections and Immunology Research
Indian Institute of Technology Roorkee
2025
Banaras Hindu University
2022-2023
Indian Institute of Technology BHU
2022-2023
Structural virology has emerged as the foundation for development of effective antiviral therapeutics. It is pivotal in providing crucial insights into three-dimensional frame viruses and viral proteins at atomic or near atomic-level resolution. Structure-based assessment components, including capsids, envelope proteins, replication machinery, host interaction interfaces, are instrumental unravelling multiplex mechanisms infection, replication, pathogenesis. The structural elucidation...
Malaria represents a major global health concern, primarily due to the emergence of resistance against most currently available antimalarial drugs. This pressing issue necessitates discovery novel agents combat escalating resistance. A cyclin-dependent kinase (CDK)-like protein, Pfmrk, found in Plasmodium falciparum, plays crucial role regulating cell proliferation and exhibits 36.28% sequence homology with its human counterpart hCDK7. Pfmrk forms complex plasmodial cyclin (Pfcyc-1)...
Abstract Malaria is a major global health issue due to the emergence of resistance most available antimalarial drugs. There an urgent need discover new antimalarials tackle issue. A CDK-like protein, Pfmrk from Plasmodium falciparum , plays crucial role in regulating cell proliferation and shares 36.28% homology with humans CDK (hCDK7). complex Pfcyc-1 stimulates kinase activity. Also, P. falciparum, which has highest sequence human cyclin (Cyclin H), binds activates cyclin-dependent way....