A5001203438- Cystic Fibrosis Research Advances
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Tissue Engineering and Regenerative Medicine
- Muscle Physiology and Disorders
- Tracheal and airway disorders
- Infant Development and Preterm Care
- Electrospun Nanofibers in Biomedical Applications
- Congenital Anomalies and Fetal Surgery
- Asthma and respiratory diseases
- Pneumonia and Respiratory Infections
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Clinical Nutrition and Gastroenterology
- Child Nutrition and Feeding Issues
- Congenital heart defects research
- Genetics, Aging, and Longevity in Model Organisms
- Healthcare Regulation
- Dental Trauma and Treatments
- Cardiac electrophysiology and arrhythmias
- Silk-based biomaterials and applications
- Folate and B Vitamins Research
- Biological Research and Disease Studies
- Intestinal Malrotation and Obstruction Disorders
- Dental Health and Care Utilization
Universidade de São Paulo
2016-2025
Hospital Regional de Presidente Prudente
2024
Universidade Estadual de Campinas (UNICAMP)
2004-2023
Hospital de Clínicas da Unicamp
2008-2023
PluriCell (Brazil)
2021
Biotech (Brazil)
2021
Universidade Federal de Minas Gerais
2021
Stem Cell Institute
2016
Masaryk University
2008
Abstract Satellite cells (SCs) are the main muscle stem responsible for its regenerative capacity. In muscular dystrophies, however, a failure of process results in degeneration and weakness. To analyze effect different degrees SCs behavior, we studied adult dystrophic strains: DMD mdx , Large myd / with variable histopathological alterations. Similar were observed models, which maintained normal levels PAX7 expression, retained Pax7-positive pool, their proliferation Moreover, elevated...
Abstract Background Measurements of CFTR function in rectal biopsies ex vivo have been used for diagnosis and prognosis Cystic Fibrosis (CF) disease. Here, we aimed to evaluate this procedure regarding: i) viability the specimens obtained by biopsy forceps bioelectrical biochemical laboratory analyses; ii) overall assessment (comfort, invasiveness, pain, sedation requirement, etc.) from patients perspective assess its feasibility as an outcome measure clinical trials. Methods We compared...
Objective: To analyze the characteristics of cystic fibrosis (CF) care centers (CFCCs) in Brazil. Methods: A questionnaire was sent to coordinators all 51 registered CFCCs between May and September 2021. Results: The response rate 100%. Southeastern Brazil is region where most country are located (21 centers; 41%), followed by southern northeastern regions (11 each; 21.5%), central-western (6; 12%), northern (2; 4%). total 4,371 patients with CF were cared for during study period, ranging...
The mdx mouse is a good genetic and molecular murine model for Duchenne Muscular Dystrophy (DMD), progressive devastating muscle disease. However, this inappropriate testing new therapies due to its mild phenotype. Here, we transferred the mutation 129/Sv strain with aim create more severe DMD. Unexpectedly, functional analysis of first three generations mdx129 showed amelioration phenotype, associated less connective tissue replacement, regeneration than original mdxC57BL. Transcriptome...
The scant ability of cardiomyocytes to proliferate makes heart regeneration one the biggest challenges science. Current therapies do not contemplate re-muscularization. In this scenario, stem cell-based approaches have been proposed overcome lack regeneration. We hypothesize that early-stage hiPSC-derived (hiPSC-CMs) could enhance cardiac function rats after myocardial infarction (MI). Animals were subjected permanent occlusion left ventricle (LV) anterior descending coronary artery (LAD)....
To determine whether abnormal continuous glucose monitoring (CGM) readings (hypoglycemia/hyperglycemia) can predict the onset of cystic fibrosis-related diabetes (CFRD) and/or clinical impairment (decline in BMI FEV1) pediatric patients with fibrosis (CF).This was a longitudinal prospective cohort study involving CF without at baseline. The mean follow-up period 3.1 years. underwent 3-day CGM, performed oral tolerance test (OGTT), and had FEV1 determined OGTT, FEV1, were reassessed end...
Abstract The scant ability of cardiomyocytes to proliferate makes heart regeneration one the biggest challenges science. Current therapies do not contemplate re-muscularization. In this scenario, stem cell-based approaches have been proposed overcome lack regeneration. We hypothesize PluriCell hiPSC-derived (hiPSC-CMs) could enhance rat’s cardiac function after myocardial infarction (MI). Animals were subjected permanent occlusion Left-Ventricle (LV) anterior descending coronary artery...