A5054098528- Natural Compound Pharmacology Studies
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Biological Activities
- Phytochemistry and biological activity of medicinal plants
- Synthesis of Organic Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Traditional and Medicinal Uses of Annonaceae
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Synthesis of Indole Derivatives
- Malaria Research and Control
- Chromatography in Natural Products
- Polymer composites and self-healing
- Carbohydrate Chemistry and Synthesis
- Photochromic and Fluorescence Chemistry
Universitas Gadjah Mada
2019-2024
Epidermal growth factor receptor (EGFR) is found to be overexpressed in cancer cells as it controls angiogenesis, cell signaling, and proliferation mechanisms. Therefore, EGFR has been known a common target for the initial screening of new anticancer agents. Either xanthone or chalcone evaluated agents, their activity strongly depends on type position attached functional group. molecular hybridization between could yield novel agents through inhibition mechanism. Herein, series...
Indonesia is rich with essential oils such as anise and clove leave oils. In respect to explore the potential utilization of these resources, it has been conducted transformation p-hydroxybenzaldehyde vanillin (4-hydroxy-3-methoxy benzaldehyde) respectively derived from oil leaves a series C-arylcalix[4]resorcinarenes C-arylcalix[4]pyrogallolarene macrocycles. Treatment aldehydes resorcinol in presence HCl absolute ethanol at reflux for 8 h afforded C-4-hydroxyphenylcalix[4]resorcinarene...
Abstract In the present work, three hydroxyxanthones were synthesized in 11.15–33.42% yield from 2,6-dihydroxybenzoic acid as starting material. The chemical structures of prepared have been elucidated by using spectroscopic techniques. Afterward, evaluated antioxidant agents through radical scavenging assay; and anticancer vitro assays against WiDr, MCF-7, HeLa cancer cell lines. Hydroxyxanthone 3b was categorized a strong agent (IC 50 = 349 ± 68 µM), while other compounds moderate > 500...
The previous study showed that xanthone had antiplasmodial activity. Xanthone, with additional hydroxyl groups, was synthesized to increase its One of the strategies evaluate a compound can be developed into an antimalarial drug is by testing mechanism in inhibiting heme polymerization. In acidic condition, hematin polymerized β-hematin vitro, which analog hemozoin Plasmodium. This conducted activity hydroxyxanthone derivative compounds on two strains Plasmodium falciparum 3D-7 and FCR-3,...
An application of moderately T2-weighted 3D TSE-FS pulse sequence to MRI myelography in investigation patient with cervical spondylotic radiculopathyHusbani Mohd Amin Rebuan, Elinah Ali, Mohdezani Aziz, Nasir Mohamad, Mainul Haque
Nowadays, cancer is one of the most fatal diseases in developed and developing countries. Therefore, it an urgent need to find more effective anticancer drugs among recent commercially available standard drugs. Xanthone derivatives have been researched as due their ease synthesis structure modification, well excellent activity. In this work, vitro activity hydroxyxanthones against human liver carcinoma cell line (HepG2) was evaluated. Among twenty-two hydroxyxanthones,...
Breast cancer is a severe global disease for women as the number of deaths increases annually. Therefore, attempts to find new anticancer agents are critical and inevitable. In this work, we report investigation on activity xanthone cinnamoylbenzene compounds against two breast cell lines, i.e., T47D MCF-7, through experimental in vitro theoretical silico assays. Xanthone exhibit with half-maximal inhibitory concentration (IC50) 136.7–194.3 235.8–262.4 µg/mL MCF-7 cells, respectively....