Lei Gao

ORCID: 0000-0003-0377-2746
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About
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Research Areas
  • Fluid Dynamics and Turbulent Flows
  • Aerodynamics and Acoustics in Jet Flows
  • Computational Fluid Dynamics and Aerodynamics
  • Fluid Dynamics and Vibration Analysis
  • Heat Transfer Mechanisms
  • Plasma and Flow Control in Aerodynamics
  • Tribology and Lubrication Engineering
  • Land Use and Ecosystem Services
  • Tuberculosis Research and Epidemiology
  • Immunodeficiency and Autoimmune Disorders
  • MicroRNA in disease regulation
  • Combustion and flame dynamics
  • Catalytic Processes in Materials Science
  • Remote Sensing and Land Use
  • Immune responses and vaccinations
  • Mycobacterium research and diagnosis
  • Gear and Bearing Dynamics Analysis
  • Wind and Air Flow Studies
  • Lubricants and Their Additives
  • Catalysis and Oxidation Reactions
  • Hydraulic and Pneumatic Systems
  • Environmental and Biological Research in Conflict Zones
  • Plasma Diagnostics and Applications
  • Aerodynamics and Fluid Dynamics Research
  • Tribology and Wear Analysis

Nanjing University of Chinese Medicine
2025

Sichuan University
2008-2024

Changchun Normal University
2023-2024

Nanjing University of Aeronautics and Astronautics
2009-2024

Hong Kong Polytechnic University
2024

Central South University
2024

Université Laval
2024

Health Sciences and Nutrition
2024

Commonwealth Scientific and Industrial Research Organisation
2024

Université du Québec en Abitibi-Témiscamingue
2024

Depression, a prevalent psychiatric disorder of ambiguous etiology and high heterogeneity, has been recently linked to the primary visual cortex (V1). However, precise circuits mediating impact V1 on depressive-like behaviors are poorly understood. Here, we demonstrate that V1, specifically lateral posterior nucleus thalamus (LP)-projecting glutamatergic subpopulation (GluV1→LP neurons), shows reduced activity after chronic restraint stress (CRS) in male mice, leading behaviors. Optogenetic...

10.1038/s41467-024-55600-4 article EN cc-by-nc-nd Nature Communications 2025-02-06

Modifications have been made to an analytical model proposed by Shusser & Gharib ( J. Fluid Mech ., vol. 416, 2000 b , pp. 173–185) for the vortex ring formation and pinch-off process in a starting jet. Compared with previous models, present investigation distinguishes leading from its trailing jet so as consider details of terms properties ring, which are determined considering flux kinetic energy, impulse circulation into convective transportation. A two-stage has identified before...

10.1017/s0022112010001138 article EN Journal of Fluid Mechanics 2010-05-21

The effects of the nozzle exit geometry on unsteady propulsive characteristics single-pulsed jets are studied numerically. For both tube and orifice nozzles, jet configuration is parameterized by diameter ratio RD, which defined as entrance D0 to diameters D. It found that has significant influence during its entire ejection phase. total impulse production augmented considerably increases until a critical value RD_cir≈2.0 approached. larger nozzles over stems from persistent over-pressure...

10.1063/5.0176021 article EN Physics of Fluids 2024-01-01

The formation process of a vortex pair generated by two-dimensional starting jet has been investigated numerically over range Reynolds numbers from 500 to 2000. effects stroke ratio and nozzle configuration are examined. Only single can be observed in the vorticity field small ratios less than 10 while leading formed larger eventually disconnects trailing jet. (13.6 9.3) for straight an orifice have identified circulation criterion they further analysed four other criteria. Using contraction...

10.1017/jfm.2025.3 article EN Journal of Fluid Mechanics 2025-03-14

Introduction The clinical translation of mesenchymal stem cell-derived exosome faces critical challenges in scalable production, subpopulation stability, and therapeutic route optimization. This study systematically addresses these barriers to advance exosome-based therapies. Methods We established a 28-day biomanufacturing workflow using Hollow Fiber 3D bioreactor integrated with the RoosterBio exosome-harvesting system. Exosomes were subsequently purified rigorously characterized at...

10.3389/fcell.2025.1550447 article EN cc-by Frontiers in Cell and Developmental Biology 2025-05-27

Abstract Experiments on a circular starting jet generated by piston–cylinder arrangement, over range of Reynolds number from $2600$ to $5600$ , are conducted so as investigate the development trailing shear layer during leading vortex ring formation, well corresponding effects pinch-off process. Results obtained digital particle image velocimetry (DPIV) show that secondary vortices start develop in only after critical time scale, ‘formation number’, is achieved. The subsequent growth reduces...

10.1017/jfm.2012.138 article EN Journal of Fluid Mechanics 2012-04-30

An analytical model that can be used to predict the circulation growth process for non-impulsive starting jets has been developed by extending over-pressure correction impulsive jets. Only jet velocity function U0(t) is needed obtain of jet. The generated nozzle and orifice configurations are performed numerically with two acceleration schemes (represented kinds functions) different stage stroke ratios LaD (modifying time ta in each LaD=0.05:0.2:1.25) verify accuracy proposed model....

10.1063/5.0147768 article EN Physics of Fluids 2023-05-01

Recent development in the Web of Things (WoT) domain makes it possible to access sensor data via web. While due different structures and interfaces networks, it's not that easy fully integrating their web then share reuse later. This paper introduces a platform using RESTful API help data. First explains significance advantage adopting style API, points out architecture this platform. Later proposes protocols Finally typical application scene is described analyzed.

10.1109/itap.2011.6006157 article EN International Conference on Internet Technology and Applications 2011-08-01

The limiting process of vortex ring formation in starting forced plumes, with Richardson number the range −0.06 ≤ Ri 0.06, was studied numerically under Boussinesq approximation. examination dynamics flow evolution reveals that plume-ambient density difference affects pinch-off mainly through three mechanisms, i.e., baroclinic production vorticity, buoyancy acceleration (or deceleration) on vortical structures, and its effect trailing shear layer instability. As increases from negative to...

10.1063/1.4966648 article EN Physics of Fluids 2016-11-01

The formation process of the leading vortex ring in starting jets with uniform background co- and counter-flow has been studied numerically for $-0.5\leq R_v\leq 0.5$ , where $R_v$ is ratio velocity to jet velocity. For cases counter-flow, normal would be destroyed when $R_v<-0.4$ i.e. trailing overtake through centre, a phenomenon reminiscent leapfrogging. As increases, number $F_{t^*}$ decreases from $9.6$ at $R_v=-0.4$ $1.92$ $R_v=0.5$ . An analytical model based on kinematic criterion...

10.1017/jfm.2023.586 article EN Journal of Fluid Mechanics 2023-08-07

Non-small cell lung cancer (NSCLC) is the most prevalent subtype of histologically, and an increasing number evidences have shown during past years that long non-coding RNAs (lncRNAs) are involved in tumorigenesis.Here we found a RNA, GATA2-AS1, repressing NSCLC cells proliferation via regulating GATA2.GATA2-AS1 gene located at antisense strand GATA2 on chromosome while GATA2-AS1 RNA interacts with GATA1 protein promoter region then inhibits its transcription.Moreover, transcriptionally...

10.4149/neo_2019_190210n112 article EN Neoplasma 2019-01-01

Bump-type gas foil bearing is a special type of sliding bearing, especially suitable for supporting rotors with light loads and high speeds. In this paper, deformation model bump established by using elastic mechanics theory. A fluid-structure interaction algorithm proposed according to Reynolds equation compressible gas. On basis, method calculating the static dynamic characteristics bump-type considering structure parameters foil. The presented validated data reported in existing research....

10.1177/1350650120912609 article EN Proceedings of the Institution of Mechanical Engineers Part J Journal of Engineering Tribology 2020-03-16
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