A5071647355- Nanoplatforms for cancer theranostics
- Advanced Photocatalysis Techniques
- Carbon and Quantum Dots Applications
- Graphene and Nanomaterials Applications
- Osteoarthritis Treatment and Mechanisms
- Advanced Nanomaterials in Catalysis
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Hip and Femur Fractures
- Shoulder and Clavicle Injuries
- Copper-based nanomaterials and applications
- Bone fractures and treatments
- Luminescence and Fluorescent Materials
- Pelvic and Acetabular Injuries
- Elbow and Forearm Trauma Treatment
- Spinal Fractures and Fixation Techniques
- Bone health and osteoporosis research
- Cancer-related gene regulation
- MXene and MAX Phase Materials
- Nanocluster Synthesis and Applications
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Bone health and treatments
- Inflammatory mediators and NSAID effects
Shanghai Jiao Tong University
2016-2025
Shanghai Sixth People's Hospital
2016-2025
Yancheng Second People's Hospital
2023-2024
Liaoning Technical University
2024
People’s Hospital of Wenshan Prefecture
2022
Leshan Normal University
2021
Harvard University
2004-2014
Brigham and Women's Hospital
2008-2014
Sichuan University
2013
The First Affiliated Hospital, Sun Yat-sen University
2008-2010
Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for guided therapy (SDT). It is challenging, however, to realize a single material that simultaneously endowed both NIR emitting activities. Herein, we report the design of class NIR-emitting from phosphorescent carbon dot (CD) narrow bandgap (1.62 eV) long-lived excited triplet states (11.4 μs), two which can enhance SDT as thermodynamically dynamically favorable factors under...
The immunosuppressive tumor microenvironment (TME) is a huge hurdle in immunotherapy. Sono-immunotherapy new treatment modality that can reverse TME, but the sonodynamic effects are compromised by overexpressed glutathione (GSH) and hypoxia TME. Herein, this work reports sono-immunotherapy strategy using Pd
Abstract Sonodynamic therapy as a promising noninvasive modality is being developed for tumor therapy, but there lack of next‐generation sonosensitizers that can generate full ROS at high yields and simultaneously deplete elevated levels glutathione (GSH) in cells. Semiconductor p‐n junctions are engineered high‐efficacy sonodynamic eradication using pyridine N‐doped carbon dots (N‐CDs) p ‐type semiconductor oxygen‐deficient TiO 2− x nanosheets n semiconductor. The rate constants 1 O 2 •OH...
Metal-free layered black phosphorus (BP) nanosheets with an excellent photothermal effect and large surface areas have been widely applied in biomedicine but are easily oxidized ambient conditions yielding insulating oxides adsorbed on its surface. Several chemical-functionalized strategies explored to protect thin layers of BP; however, the performance passivated BP often decreases significantly, falling behind single due strong structure perturbation. Herein, we designed constructed 0D/2D...
Developing efficient therapeutic strategies for combating bacterial infection remains a challenge owing to the indiscriminate utilization of antibiotics and prevalence multidrug-resistant (MDR) bacteria. Herein, highly graphitic-N-doped graphene quantum dots (N-GQDs) with NIR-II photothermal conversion properties were synthesized first time antibacterial therapy. The obtained N-GQDs exhibited strong NIR absorption ranging from 700 1200 nm, achieving high efficiency 77.8% 50.4% at 808 1064...
Abstract Repairing infected bone defects is hindered by the presence of stubborn bacterial infections and inadequate osteogenic activity. The incorporation harmful antibiotics not only fosters emergence multidrug‐resistant bacteria, but also diminishes properties scaffold materials. In addition, it essential to continuously monitor degradation kinetics materials at defect sites, yet majority repair lack imaging capability. To address these issues, this study reports for first time...
ABSTRACT Human skeletal aging is characterized as a gradual loss of bone mass due to an excess resorption not balanced by new formation. Using human marrow cells, we tested the hypothesis that there age‐dependent increase in osteoclastogenesis intrinsic changes regulatory factors [macrophage‐colony stimulating factor (M‐CSF), receptor activator NF‐κB ligand (RANKL), and osteoprotegerin (OPG)] their receptors [c‐fms RANK]. In cells (BMCs), c‐fms (r = 0.61, P 0.006) RANK expression 0.59,...
Sonosensitizers play crucial roles in the controlled production of reactive oxygen species (ROS) under ultrasound (US) irradiation with high tissue-penetration depth for noninvasive solid tumor therapy. It is desirable to fabricate structurally simple yet multifunctional sonosensitizers from ultrafine nanoparticles ROS-based multimode therapy overcome monomode limitations such as low ROS yields and endogenous reductive glutathione (GSH) treatment resistance. We report facile high-temperature...
Currently, one of the major hurdles hindering clinical applications photothermal therapy (PTT) and photothermal-chemo combination (PCT) is lack highly efficient, readily derived, irradiation-safe agents in biologically transparent window. Herein, we report first design rational construction 0D/2D/0D sandwich heterojunctions for greatly enhanced PTT PCT performances using 0D N-doped carbon dots 2D MoS2 nanosheets as assembly units. The well-matching enabled an additional enhancement NIR...
Vitamin D is important for bone health, with low vitamin levels being associated skeletal fragility and fractures. Among its other biological activities, 1,25-dihydroxyvitamin (1,25(OH)(2) D), stimulates the in vitro differentiation of human marrow stromal cells (hMSCs) to osteoblasts, which can be monitored by increases alkaline phosphatase enzyme activity or osteocalcin gene expression. In this study, we tested hypotheses that age clinical attributes subjects influence responsiveness hMSCs...
Abstract Accumulating evidence suggests that circular RNAs (circRNAs) are abundant and play critical roles in the nervous system. However, their functions axon regeneration after neuronal injury unclear. Due to its robust capacity, peripheral system is ideal for seeking regulatory circRNAs regeneration. In present work, we obtained an expression profile of dorsal root ganglions (DRGs) rat sciatic nerve crush by RNA sequencing (RNA-Seq) found level circ-Spidr was obviously increased using...