A5045782024- Adenosine and Purinergic Signaling
- Chemokine receptors and signaling
- Chemical Synthesis and Analysis
- Immunotherapy and Immune Responses
- Click Chemistry and Applications
- Testicular diseases and treatments
- T-cell and B-cell Immunology
- Viral Infections and Vectors
- Nanoplatforms for cancer theranostics
- Essential Oils and Antimicrobial Activity
- Obstructive Sleep Apnea Research
- Urinary and Genital Oncology Studies
- Lipid metabolism and biosynthesis
- Neuroblastoma Research and Treatments
- Bee Products Chemical Analysis
- RNA modifications and cancer
- Chemotherapy-induced organ toxicity mitigation
- S100 Proteins and Annexins
- interferon and immune responses
- Sleep and Wakefulness Research
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Sleep and related disorders
- Bladder and Urothelial Cancer Treatments
- Pregnancy and Medication Impact
Fudan University
2025
Zhongshan Hospital
2025
People's Hospital of Cangzhou
2023
Merck & Co., Inc., Rahway, NJ, USA (United States)
2003-2022
Peking University
2021
Peking University Third Hospital
2021
Genomics Institute of the Novartis Research Foundation
2021
Wenzhou Medical University
2017-2019
Second Xiangya Hospital of Central South University
2015
Central South University
2015
Pharmacological activation of the STING (stimulator interferon genes)-controlled innate immune pathway is a promising therapeutic strategy for cancer. Here we report identification MSA-2, an orally available non-nucleotide human agonist. In syngeneic mouse tumor models, subcutaneous and oral MSA-2 regimens were well tolerated stimulated interferon-β secretion in tumors, induced regression with durable antitumor immunity, synergized anti-PD-1 therapy. Experimental theoretical analyses showed...
Naïve T cells, when activated by specific antigen and cytokines, up-regulate adhesion molecules as well chemokine receptors on their surface, which allows them to migrate inflamed tissues. Human studies have shown that CXCR3 is one of the induced during cell activation. Moreover, CXCR3-positive cells are enriched at inflammatory sites in patients with autoimmune diseases such rheumatoid arthritis multiple sclerosis. In this study, we use a mouse model inflammation demonstrate required for...
Abstract Pharmacologic antagonism of CCR5, a chemokine receptor expressed on macrophages and activated T cells, is an effective antiviral therapy in patients with macrophage-tropic HIV infection, but its efficacy modulating inflammation immunity only just beginning to be investigated. In this regard, the recruitment CCR5-bearing cells into clinical allografts hallmark acute rejection may anticipate chronic rejection, whereas conventionally immunosuppressed renal transplant homozygous for...
Recent data suggest that the inhibition of arginase (ARG) has therapeutic potential for treatment a number indications ranging from pulmonary and vascular disease to cancer. Thus, high demand exists selective small molecule ARG inhibitors with favorable druglike properties good oral bioavailability. In light significant challenges associated unique physicochemical previously disclosed inhibitors, we use structure-based drug design combined focused optimization strategy discover class boronic...
Comprehensive synthetic strategies afforded a diverse set of structurally unique bicyclic proline-containing arginase inhibitors with high degree three-dimensionality. The analogs that favored the Cγ-exo conformation proline improved potency over initial lead. novel reported here not only enable access to previously unknown stereochemically complex derivatives but also provide foundation for future synthesis analogs, which incorporate inherent three-dimensional character into building...
Abstract Purpose To investigate the effect of intraoperative remimazolam sedation on postoperative sleep quality in elderly patients after total joint arthroplasty. Methods Between May 15, 2021 and March 26, 2022, 108 (age ≥ 65 years) who received arthroplasty under neuraxial anesthesia were randomized into group (a loading dose 0.025–0.1 mg/kg followed by an infusion rate 0.1–1.0 mg/kg/h till end surgery) or routine (sedation was given patient’s requirement dexmedetomidine 0.2–0.7 μg/kg/h)....
LONP1 is an AAA+ protease that maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression of promotes cancer cell proliferation resistance to apoptosis-inducing reagents. Despite the importance in human biology disease, very few inhibitors have been described literature. Herein, we report development selective boronic acid-based using structure-based drug design as well first structures bound various inhibitors. Our efforts led several...
Anacetrapib is an inhibitor of cholesteryl ester transfer protein (CETP), associated with reduction in LDL cholesterol and increase HDL hypercholesterolemic patients. was not taken forward into filing/registration as a new drug for coronary artery diease, despite the observation ∼9% cardiovascular risk large phase III outcomes trial (REVEAL). displayed no adverse effects throughout extensive preclinical safety evaluation, major signals were observed clinical trials studying anacetrapib,...
There is currently no consensus on the optimal management of de novo unilateral upper tract urothelial carcinoma (UTUC) in renal transplant recipients. We aimed to compare surgical and oncological outcomes simultaneous bilateral radical nephroureterectomy (SBRNU) (URNU) determine appropriate method.Patients who developed UTUC after transplantation underwent treatment at our center were included study. Outcomes compared between SBRNU group (underwent RNU within 3 months) URNU using...
Abstract Arginase overexpression has been associated with poor survival rates in advanced cancer patients treated Keytruda. High levels of may lead to a depletion arginine within the tumor microenvironment, inhibiting immune response. Thus, arginase inhibition potential greatly enhance immunotherapy treatment. Discovering novel inhibitors was met several challenges including analyzing/purifying extremely polar chemical matter without chromophores, synthetically challenging space, and...