A5059587893- Barrier Structure and Function Studies
- Kruppel-like factors research
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Vagus Nerve Stimulation Research
- Long-Term Effects of COVID-19
- Neurological Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Medicinal plant effects and applications
- Fibroblast Growth Factor Research
- Phytochemicals and Antioxidant Activities
- Ginkgo biloba and Cashew Applications
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- Neuroinflammation and Neurodegeneration Mechanisms
State Research Institute Centre for Innovative Medicine
2021-2024
Ikerbasque
2023
China Medical University
2023
The blood-brain barrier (BBB) (discovered and defined by Max Lewandowsky Lina Stern, not, as it is universally, yet erroneously believed, Paul Ehrlich (Verkhratsky Pivoriunas, 2023)) that separates the nervous system from circulation evolutionarily conserved arthropods to man. primeval BBB of invertebrates some early vertebrates was made solely glial cells secured (in invertebrates) septate junctions; in most vertebrates, including mammals, associated with endothelial tight junctions. This,...
Abstract Multiple paracrine factors regulate the barrier properties of human brain capillary endothelial cells (BCECs). Understanding precise mode action these remains a challenging task, because limited availability functionally competent BCECs and use serum‐containing medium. In present study, we employed defined protocol for producing from inducible pluripotent stem cells. We found that autocrine secretion basic fibroblast growth factor (bFGF) is necessary establishment tight barrier, as...
Abstract The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 instigated the most serious global health crisis. Clinical presentation COVID-19 frequently includes neurological and neuropsychiatric symptoms. However, it is presently unknown whether to which extent pathological impairment blood-brain barrier (BBB) contributes development neuropathology during progression. In present study, we used human induced pluripotent stem cells-derived brain...
Abstract The pandemic of Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) instigated the most serious global health crisis. Clinical presentation COVID-19 frequently includes neurological and neuropsychiatric symptoms. However, it is presently unknown whether to which extent pathological impairment blood-brain barrier (BBB) contributes development neuropathology during progression. In present study we used human induced pluripotent...
Abstract Multiple paracrine factors have been implicated in the regulation of barrier properties human brain endothelial cells (BECs) different physiologic and pathologic settings. We recently demonstrated that autocrine secretion basic fibroblast growth factor (bFGF) by BECs is necessary for establishment (as high trans-endothelial electric resistance, TEER), whereas exogenous bFGF inhibits TEER a concentration-dependent manner. In present study we analysed contribution MAPK/ERK STAT3...
Abstract Multiple paracrine factors regulate barrier properties of human brain capillary endothelial cells (BCECs). Understanding precise mode action these remains a challenging task because the limited availability functionally competent BCECs and use serum-containing medium. In present study we employed defined protocol for producing from inducible pluripotent stem cells. We found that autocrine secretion basic fibroblast growth factor (bFGF) is necessary establishment tight barrier, as...