A5051000453- Cellular Mechanics and Interactions
- Electrohydrodynamics and Fluid Dynamics
- 3D Printing in Biomedical Research
- Microfluidic and Capillary Electrophoresis Applications
- Mathematical Biology Tumor Growth
- Gene Regulatory Network Analysis
- Heat and Mass Transfer in Porous Media
- Evolution and Genetic Dynamics
- Traumatic Brain Injury and Neurovascular Disturbances
- Field-Flow Fractionation Techniques
- Bacillus and Francisella bacterial research
- Groundwater flow and contamination studies
- Advanced Biosensing Techniques and Applications
- Heat shock proteins research
- Fluid Dynamics and Turbulent Flows
- Lattice Boltzmann Simulation Studies
- Analytical Chemistry and Sensors
- Microfluidic and Bio-sensing Technologies
- Mesenchymal stem cell research
- Particle Dynamics in Fluid Flows
- Innovative Microfluidic and Catalytic Techniques Innovation
- Micro and Nano Robotics
- GABA and Rice Research
- Cell Image Analysis Techniques
- Pituitary Gland Disorders and Treatments
University of Copenhagen
2016-2024
Technical University of Denmark
2009-2014
In multicellular organisms and complex ecosystems, cells migrate in a social context. Whereas this is essential for the basic processes of life, influence neighboring on individual remains poorly understood. Previous work isolated has observed stereotypical migratory behavior characterized by short-time directional persistence with long-time random movement. We discovered much richer dynamic context, significant variations directionality, displacement, speed, which are all modulated local...
Introduction High cell density is known to enhance adipogenic differentiation of mesenchymal stem cells, suggesting secretion signaling factors or cell-contact-mediated signaling. By employing microfluidic biochip technology, we have been able separate these two processes and study the pathways. Methods results Adipogenic human adipose-derived cells (ASCs) cultured in a system was investigated under perfusion conditions with an medium supplemented supernatant from differentiating ASCs...
Abstract Taylor–Aris dispersion, the shear-induced enhancement of solute diffusion in flow direction solvent, has been studied intensely past half century for case steady and single-frequency pulsating flows. Here, combining Aris’s method moments with Dirac’s bra–ket formalism, we derive an expression effective diffusivity valid transient dispersion any given time-dependent, multi-frequency solvent through straight channels. Our theory shows that may be greatly enhanced by time-dependent...
Abstract Based on the method of moments, we derive a general theoretical expression for time-dependent dispersion an initial point concentration in steady and unsteady laminar flows through long straight channels any constant cross-section. We retrieve generalize previous case-specific results, furthermore predict new phenomena. In particular, transient phase before well-described Taylor–Aris limit is reached, find anomalous diffusion with dependence temporal scaling exponent release point,...
An understanding of all fluid dynamic time scales is needed to fully understand and hence exploit the capabilities flow in microfluidic systems. We propose use harmonically oscillating microfluidics as an analytical tool for deduction these scales. Furthermore, we suggest system-level equivalent circuit theory adequate behavior system. A novel pressure source capable operation desired frequency range presented this generic analysis. As a proof concept, study fairly complex system...
To date hydrocephalus researchers acknowledge the need for rigorous but utilitarian fluid mechanics understanding and methodologies in studying normal hydrocephalic intracranial dynamics. Pressure volume models electric circuit analogs introduced pressure into conservation; control analysis enforces independent conditions on volume. Previously, utilization of clinical measurements has been limited to relative amplitude timing flow, waveforms; qualitative approaches without a clear framework...
By diversifying, cells in a clonal population can together overcome the limits of individuals. Diversity single-cell growth rates allows to survive environmental stresses, such as antibiotics, and grow faster than undiversified population. These functional cell-cell variations arise stochastically, from noise biochemical reactions, or deterministically, by asymmetrically distributing damaged components. While each mechanisms is well understood, effect combined unclear. To evaluate...
Abstract By diversifying, cells in a clonal population can together overcome the limits of individuals. Diversity single-cell growth rates allows to survive environmental stresses, such as antibiotics, and grow faster than undiversified population. These functional cell-cell variations arise stochastically, from noise biochemical reactions, or deterministically, by asymmetrically distributing damaged components. While each mechanism is well understood, effect combined mechanisms unclear. To...