A5079939331- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Tracheal and airway disorders
- Head and Neck Surgical Oncology
- Esophageal and GI Pathology
- Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Oral and Maxillofacial Pathology
- Ear and Head Tumors
- Voice and Speech Disorders
- Thyroid and Parathyroid Surgery
- Dysphagia Assessment and Management
- Bone Tumor Diagnosis and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Head and Neck Anomalies
- Nutrition and Health in Aging
- Cleft Lip and Palate Research
- Cardiac, Anesthesia and Surgical Outcomes
- Thyroid Disorders and Treatments
- Meningioma and schwannoma management
- Gastric Cancer Management and Outcomes
- Enhanced Recovery After Surgery
- Oral health in cancer treatment
National Cancer Center Hospital East
2016-2025
University of Tokyo Hospital
2023
Tokyo Medical and Dental University Hospital
2023
Shinshu University
2017
Yamaguchi Red Cross Hospital
2006-2010
Mie University
2010
Meiji (Japan)
1985
Abstract Background To determine the safety, preliminary efficacy, pharmacokinetics, and immunogenicity of a single cycle RM-1929 photoimmunotherapy, an anti-EGFR antibody cetuximab conjugated with light-activatable dye (IRDye ® 700DX), in Japanese patients recurrent head neck squamous cell carcinoma (rHNSCC). Methods Patients received fixed dose (640 mg/m 2 ) light treatment (50 J/cm for superficial illumination; 100 fiber diffuser length interstitial illumination). Safety, tumor response...
Abstract Background There are no published reports evaluating the ability of artificial intelligence (AI) in endoscopic diagnosis superficial laryngopharyngeal cancer (SLPC). We presented our newly developed diagnostic AI model for SLPC detection. Methods used RetinaNet object and normal mucosal images obtained from narrow‐band imaging were learning validation data sets. Each independent set comprised 400 800 images. The was constructed stage‐wise evaluated at each stage using Results In...
Photoimmunotherapy is a novel cancer treatment that recently became covered by national health insurance in Japan, but decision-making remains challenging for unresectable advanced or recurrent head and neck cancer. We aimed to clarify the characteristics of patients whom photoimmunotherapy was indicated retrospective chart review. Patients aged ≥20 years diagnosed with who started receiving systemic therapy at National Cancer Center Hospital East from January 2016 through December 2020 were...
Concomitant chemoradiation therapy is a standard treatment for head and neck cancer. Thus, salvage surgery has become necessary treatment. The aim of the study was to evaluate results by each site neck, especially oropharynx, hypopharynx larynx.This retrospective, single-institute study. primary endpoint overall survival. Secondary endpoints were disease-free survival, locoregional control rate after surgery, indication reasons contraindications post-operative complication predictors...
Ultrasound (US) imaging is a first-line medical modality for detecting thyroid cancer; however, it suffers from operator-dependent variability in image quality and diagnostic accuracy. To address this issue, various robotic US systems have been proposed to assist examinations. Nevertheless, ensuring an appropriate contact force that balances patient safety during scanning remains challenge. Thyroid procedures require physicians be very cautious applying pressure the neck due sensitivity of...
Early-stage oral or oropharyngeal carcinomas are often treated with surgical resection. Resulting wounds that too large for primary closure can be covered skin grafts patches made from various biomaterials. Recently, polyglycolic acid sheets have been used this purpose.We six patients resulting the resection of squamous cell carcinoma by grafting sheet patches. All were initially at National Cancer Center East Hospital March 2010 through July 2012. After mucosal resection, attached fibrin...
Delayed cervical lymph node metastasis (CLNM) is the most negative prognostic factor of tongue squamous cell carcinoma (SCC). This study analyzed relationship between clinicopathologic factors, including anatomic invasive depth (AID), and CLNM. A total 212 patients with clinically node-negative (cN0) SCC who had undergone partial glossectomy through mouth were eligible for this retrospective study. The deepest portions where cells invaded as determined by microscopic analyses classified into...
We aimed to clarify the suitable surgical management around paratracheal area of patients who undergo total pharyngolaryngectomy based on pathological results hypopharyngeal cancer. The study was conducted under a multicenter, retrospective observational design in Japan. analyzed histopathological lymph node metastasis and thyroid invasion, recurrence for 184 underwent initial surgery among 280 participants. There were significant differences frequency nodes as cN advances (P = 0.0344) cT...
<b>Background and study aims: </b>Local failure after radiation therapy for pharyngeal squamous cell carcinoma (PSCC) is problematic. The safety of endoscopic resection lesions within the (RT) field has not been assessed. We evaluated salvage in patients with locoregional definitive radiotherapy PSCC. <b>Patients methods: </b>We retrospectively clinical outcomes long-term survival 16 initially treated more than 60 Gy These later presented 19 superficial metachronous or recurrent PSCC were...
The incidence rate has been increasing for superficial head and neck squamous cell carcinoma (HNSCC) discovered through surveillance endoscopic study using narrow band imaging (NBI), a procedure mainly used high-risk patients with esophageal (ESCC). However, there are few reports on the natural history of HNSCC. aim this retrospective was to investigate HNSCC.From January 2007 December 2012, 535 consecutive histologically confirmed HNSCCs at oropharynx, hypopharynx, or larynx in 319 were...
Abstract Background Perioperative management methods that reduce surgery-associated invasiveness and improve the quality of postoperative recovery are being promoted as enhanced after surgery programs in various areas. Early enteral nutrition mobilization essential elements for surgery; however, their safety feasibility unclear head neck with free tissue transfer reconstruction. This study aimed to clarify these uncertainties. Methods is a retrospective before–after study. From 2018 2022,...
Abstract Background We investigate the feasibility of using artificial intelligence (AI) to identify recurrent laryngeal nerve (RLN) during endoscopic thyroid surgery and evaluated its accuracy. Methods In this retrospective study, we develop an AI model a dataset videos, including hemithyroidectomy procedures performed between April 2019 September 2023 at National Cancer Center Hospital East, Chiba, Japan. Semantic segmentation deep learning methods were applied analyze videos. Results...
Hypopharyngeal cancers frequently go undetected until advanced stages. However, recent advances in endoscopic technology have enabled earlier detection of hypopharyngeal cancer. We evaluated the effectiveness larynx-preserving surgery for cancer.We retrospectively analyzed 99 patients with squamous cell carcinoma who underwent partial hypopharyngectomy larynx preservation between September 1992 and December 2009 at National Cancer Center Hospital East. Of these, 91 as initial treatment;...
The indication for elective neck dissection patients with clinically T4aN0 (cT4aN0) glottic cancer is not established. objective of this study was to evaluate the role cT4aN0 cancer. We assessed laryngeal squamous cell carcinoma who underwent total laryngectomy between 1998 and 2014 conducted a retrospective analysis. considered occult metastasis positive when confirmed by histological When late metastases did undergo therapeutic dissection, presence judged on basis computed tomography....
Understanding the miss rate and characteristics of missed pharyngeal laryngeal cancers during upper gastrointestinal endoscopy may aid in reducing endoscopic this cancer type. However, little is known regarding such cancers. Therefore, aim study was to investigate oro-hypopharyngeal cancers, risk factors associated with cancers.Patients who underwent were pathologically diagnosed squamous cell carcinoma from January 2019 November 2020 at our institution retrospectively evaluated. Missed...
Post-operative concurrent chemoradiotherapy significantly improves the rates of locoregional control and disease-free survival in high-risk patients but has significant adverse effects. Percutaneous endoscopic gastrostomy opioid-based pain increase treatment completion can result dysphagia.The rate duration use prophylactically placed percutaneous gastrostomies were evaluated 43 who underwent post-operative radiotherapy or from April 2007 through March 2010. All completed received 60 Gy more...