A5065655312- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Vitamin C and Antioxidants Research
- T-cell and B-cell Immunology
- Vitamin D Research Studies
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Breastfeeding Practices and Influences
- Protein Degradation and Inhibitors
- Virus-based gene therapy research
- RNA modifications and cancer
- Exercise and Physiological Responses
- Single-cell and spatial transcriptomics
- Infant Nutrition and Health
- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 Impact on Reproduction
City Of Hope National Medical Center
2021-2023
Kiel University
2017-2021
University Hospital Schleswig-Holstein
2017-2020
University of Lübeck
2017-2020
Abstract Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. Due to their HLA-independent mode of action, allogeneic can be considered clinical application. To apply in adoptive immunotherapy, the methodology used obtain adequate cell numbers with optimal effector function vitro needs optimized, and safety efficacy also need proven. Therefore, we developed a novel formula improve expansion peripheral γδ from healthy donors. Then, humanized mouse model validate...
γδ T cells are of interest as effector for cellular immunotherapy due to their HLA-non-restricted lysis many different tumor cell types. Potential applications include the adoptive transfer in vitro-expanded cells. Therefore, it is important optimize culture conditions enable maximal proliferative and functional activity. Vitamin C (L-ascorbic acid) an essential vitamin with multiple effects on immune It a cofactor several enzymes, has antioxidant activity, epigenetic modifier. Here, we...
TGF-β is a pleiotropic cytokine with multiple roles in immunity. Apart from its suppressive activity, driving the differentiation of induced regulatory T cells (iTreg) but also polarization interleukin-9 (IL-9) producing helper 9 (Th9) cells. Human Vδ2 expressing γδ exert potent cytotoxicity towards variety solid tumor and leukemia/lymphoma target thus are focus current strategies to develop cell-based immunotherapies. Here we report that unexpectedly augments cytotoxic effector activity...
Human γδ T cells are potent cytotoxic effector cells, produce a variety of cytokines, and can acquire regulatory activity. Induction FOXP3, the key transcription factor (Treg), by TGF-β in human Vγ9 Vδ2 has been previously reported. Vitamin C is an antioxidant acts as multiplier DNA hydroxymethylation. Here we have investigated effect more stable phospho-modified (pVC) on TGF-β-induced FOXP3 expression resulting activity highly purified cells. pVC significantly increased stability also...
Abstract Outcomes for pediatric brain tumor patients remain poor, and there is optimism that chimeric antigen receptor (CAR) T cell therapy can improve prognosis. Here, we present interim results from the first six treated on an ongoing phase I clinical trial (NCT04510051) of IL13BBζ-CAR cells delivered weekly into lateral cerebral ventricles, identifying clonal expansion endogenous CAR-negative CD8 + in cerebrospinal fluid (CSF) over time. Additionally, five evaluable disease response,...
OPINION article Front. Immunol., 13 March 2018Sec. T Cell Biology Volume 9 - 2018 | https://doi.org/10.3389/fimmu.2018.00512