A5084032511- Thyroid Cancer Diagnosis and Treatment
- Blood properties and coagulation
- Thyroid and Parathyroid Surgery
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parathyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- BRCA gene mutations in cancer
- Lipid metabolism and disorders
- Erythrocyte Function and Pathophysiology
- Microtubule and mitosis dynamics
- Medical Imaging and Pathology Studies
- Thyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Head and Neck Anomalies
- Protease and Inhibitor Mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Blood transfusion and management
- Peripheral Artery Disease Management
- Biomarkers in Disease Mechanisms
Sapienza University of Rome
2013-2022
Oulu University Hospital
2010
Fondazione IRCCS Istituto Nazionale dei Tumori
2003
University of Palermo
1987-2002
University of Pavia
1999
Istituto Superiore di Sanità
1998
University of Modena and Reggio Emilia
1997
Policlinico Umberto I
1997
In Brief Objective: To conduct a retrospective study of 39 patients with papillary carcinoma the thyroid histologic vascular invasion (VI+) and 361 without any sign (VI−). Summary Background Data: present study, we undertook analysis to assess whether histologically determined can be considered predictive factor for prognosis. Methods: By means evaluated department's database who had undergone total thyroidectomy from January 1993 December 1999. Results: Group I consisted (VI−) comprising...
Background The rapid and dramatic incursion of the Internet social networks in everyday life has revolutionised methods exchanging data. Web 2.0 represents evolution as we know it. users are no longer passive receivers, actively participate delivery information. Medical education cannot evade this process. Increasingly, students using tablets smartphones to instantly retrieve medical information on web or materials their Facebook pages. educators ignore continuing revolution, therefore...
The new Italian cytological classification (2014) of thyroid nodules replaced the TIR3 category old (2007) with two subclasses, TIR3A and TIR3B, aim reducing rate surgery for benign diseases. Moreover, imaging reporting data system (TI-RADS) score appears to ameliorate stratification malignancy risk. We evaluated whether has improved diagnostic accuracy its association TI-RADS could improve prediction. retrospectively analyzed 70 from patients classified as according who underwent...
Thyroid nodules that are read on cytology as follicular or Hürthle cell neoplasms (FN and HN, respectively) indeterminate for malignancy require surgery to differentiate benign from malignant nodules. We analyzed FN HN with determine if there were differences in the rate types of thyroid was influenced by age sex.We 463 an cytological diagnosis 140 HN. The histopathological after thyroidectomy method establishing type malignancy.For entire series 603 patients 106 (17.6%) cancer; 80 these had...
The urokinase plasminogen activating system is implicated in neoplastic progression, and high tissue levels of components correlate with poor prognosis various human cancers.The objective the study was to investigate prognostic relevance activator (uPA), its cognate receptor (uPAR), inhibitor 1 (PAI-1) papillary thyroid cancer (PTC).The expression uPA, uPAR, PAI-1 genes analyzed PTC normal matched tissues by quantitative RT-PCR. case consisted 99 patients (21 males 78 females) affected...
In a group of normal controls and in diabetics subdivided for type we evaluated the following red blood cell parameters: superoxide dismutase (SOD), glutathione peroxidase (GSH.Px), catalase (C-ase), content (GSH) membrane-protein-sulphydryl groups (P-SH). There was no difference enzymatic activities dismutase, normals diabetics. However, erythrocyte GSH as well membrane P-SH discriminate from also type. None these parameters related to filterability considered reflection deformability....
It has been suggested that patients with papillary thyroid cancer (PTC) harbouring the BRAF(V600E) mutation have a worse prognosis. We showed in PTC high levels of urokinase plasminogen activator (uPA) and its cognate receptor (uPAR) inversely correlate disease-free interval (DFI).To investigate effects on expression uPA uPAR to evaluate prognostic relevance alone or combination uPAR. DESIGN/SETTING/PATIENTS/INTERVENTION: The case study included 91 PTC. All underwent thyroidectomy...
We here analyzed the prevalence of extra-thyroidal malignancies (EM) in 6,386 female patients affected by different thyroid disease (TD). At first, an age-matched analysis EM all was performed. then evaluated four TD diagnostic categories: non-nodular (n = 2,159); solitary nodule 905); multinodular 2,871); differentiated cancers 451). Finally, were grouped based on absence 3,820) or presence anti-thyroglobulin (TgAb) and/or anti-thyroperoxidase (TPOAb) 2,369), anti-Thyroid Stmulating Hormone...
A number of reports indicated that Aurora-A or Aurora-B overexpression represented a negative prognostic factor in several human malignancies. In thyroid cancer tissues deregulated expression Aurora kinases has been also demonstrated, butno information regarding its possible role differentiated is available. Here, weevaluated and mRNA relevance series 87 papillary cancers (PTC), with median follow-up 63 months. The analysis levels PTC tissues, compared to normal matched revealed their was...
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) CTLA-4 (CD80 CD86) represents a tumor strategy to escape the immune surveillance. Here, expression PD-L1 , PD-L2 CD80 CD86 was evaluated at mRNA level in 94 patients affected by papillary thyroid carcinoma (PTC) 11 anaplastic (ATC). Variations mRNAs PTC were then correlated with clinicopathological features. all genes deregulated ATC tissues compared normal tissues. In particular, downregulation observed above ATC. addition, increased...
The American Joint Committee on Cancer has revised the Tumor-Node-Metastasis (TNM) staging system for papillary thyroid cancer (PTC) patients. We examined impact of this new classification (TNM-8) patient stratification and estimated prognostic value clinicopathological features disease-free interval (DFI) in a cohort 1148 PTC Kaplan–Meier analyses showed that all parameters analyzed, except age multifocality, were associated significantly with DFI. Cox regression identified tall cell...
The transcription factors involved in epithelial–mesenchymal transition (EMT-TFs) silence the genes expressed epithelial cells (e.g., E-cadherin) while inducing those typical of mesenchymal vimentin). core set EMT-TFs comprises Zeb1, Zeb2, Snail1, Snail2, and Twist1. To date, information concerning their expression profile clinical utility during thyroid cancer (TC) progression is still incomplete. We evaluated EMT-TF, E-cadherin, vimentin mRNA levels 95 papillary TC (PTC) 12 anaplastic...
Background —Cryptosporidiosis has been shown to be a common cause of diarrhoea in both immunocompetent and immunosuppressed individuals. There are very few data on the distribution Cryptosporidium parvum along gastrointestinal tract. Aims —To evaluate location parasites digestive tract patients with AIDS. Methods —Gastrointestinal localisation C was studied 71 AIDS who underwent upper and/or lower endoscopy biopsy for chronic diarrhoeal illness other disorders unexplained origin. Results...