A5017000616- Nanoplatforms for cancer theranostics
- Glycosylation and Glycoproteins Research
- Bioactive Compounds and Antitumor Agents
- Histone Deacetylase Inhibitors Research
- Phytochemical compounds biological activities
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Mass Spectrometry Techniques and Applications
- Immune cells in cancer
- Bone and Dental Protein Studies
- Advanced Proteomics Techniques and Applications
- Molecular Biology Techniques and Applications
- Inflammatory mediators and NSAID effects
- Cancer Research and Treatments
- Gastroesophageal reflux and treatments
- Carbon and Quantum Dots Applications
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Tannin, Tannase and Anticancer Activities
- Toxoplasma gondii Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and bioactivity of alkaloids
- Photodynamic Therapy Research Studies
- Animal Genetics and Reproduction
- Nephrotoxicity and Medicinal Plants
Nantong University
2019-2024
Chinese Academy of Sciences
2014-2024
Affiliated Hospital of Nantong University
2023-2024
Institute of Optics and Electronics, Chinese Academy of Sciences
2024
Qingdao University
2021
Affiliated Hospital of Qingdao University
2021
Chinese PLA General Hospital
2010-2020
Institute of Biophysics
2014-2017
Baylor College of Medicine
2014
Chinese Academy of Agricultural Sciences
2013
Sera of Hashimoto's thyroiditis (HT) patients are known to exhibit elevated levels anti-thyroglobulin IgG (TgAb IgG). Therefore, TgAb represents a hallmark this debilitating autoimmune disease. The aim our study was investigate the differential expression specific glycosylation patterns from HT and healthy blood donors. (n = 32) were divided into two subgroups, medium level group (mHT, n 15) high (hHT, 17), according serum detected by electrochemiluminescence immunoassay. purified affinity...
Aberrant changes of N-glycan modifications on proteins have been linked to various diseases including different cancers, suggesting possible avenue for exploring their etiologies based N-glycomic analysis. Changes in patterns during epithelial ovarian cancer development so far investigated mainly using serum, plasma, ascites, and cell lines. However, N-glycans tumor tissues progression remained largely undefined. To investigate whether correlate with oncogenesis cancer, we profiled from...
BACKGROUND:Periodontitis is a chronic inflammatory disease that causes gingival detachment and disintegration of alveolar bone. Salvianolic acid C (SAC) polyphenol compound with anti-inflammatory antioxidant activities isolated from Danshen, traditional Chinese medicine made the roots Salvia miltiorrhiza Bunge. The aim this study was to investigate mechanisms underlying its protective effects inhibition effect on inflammation apoptosis in human periodontal ligament stem cells (hPDLSCs)....
Carcinoembryonic antigen (CEA) is a protein commonly found in human serum, with elevated CEA levels being linked to the progression of wide range tumors. It currently used as biomarker for malign tumors such lung cancer and colorectal [Urol Oncol: Semin Orig Invest 352: 644-648, 2013 Lung Cancer 80: 45-49, 2013]. However, due its low specificity clinical applications, can be monitoring only, rather than tumor diagnosis. The function many glycoproteins critically dependent on their...
Rationale: Precise diagnosis and effective therapy of the tumor microenvironment (TME) remains a challenge. Fluorescence tracers for monitoring primary tumors are currently reported; however, they face challenges in accurately delineating real-time during surgery, including interference from background insufficient accumulation imaging reagents at sites. Additionally, although natural product podophyllotoxin (PPT) had potent broad anti-tumor activity, poor target specificity high toxicity...
Echinococcosis is a global public health issue that generally occurs in areas with developed animal husbandry. In search of safe and effective therapeutic agents against echinococcosis, we designed synthesized new 1,3-substituted β-carboline derivatives based on harmine. Among them, compounds 1a, 1c, 1e displayed potent inhibitory activity Echinococcus granulosus vitro, significantly better than albendazole The morphological detection revealed changed the ultrastructure protoscolices (PSCs)....
A simple, rapid, and reliable liquid–liquid extraction coupled to GC–MS method was developed validated for the quantification of 22 phthalate esters (PAEs) in honey royal jelly. Instrument parameters were tested obtain satisfactory separation between PAEs with high sensitivity. The procedure optimized order achieve best recovery. following criteria used validate method: linearity, LOD, lower LOQ, precision, accuracy, matrix effect carry‐over. Correlation coefficients >0.999 by applying...
Abstract A visible‐light‐induced method was developed to synthesize selenylated cyclic boronic esters through intermolecular oxyselenenylation. This can be performed under additive‐free and photocatalyst‐free conditions generates potentially pharmaceutically useful heterocycles. plausible reaction mechanism proposed based on several control experiments previous reports.
The p53 tumor suppressor gene is highly mutated in human cancers. Individuals who inherit one mutant allele are susceptible to a wide range of types, including breast cancer and sarcoma. We recently generated knockout rats through targeting embryonic stem cells. Here we show that homozygous for the null prone early onset spontaneous sarcomas lymphoma with high incidence metastases. Heterozygous also predisposed cancer, but delayed wider spectrum types compared homozygotes. Importantly, up...
A novel theranostic co-prodrug SCB has been designed by combining a from CDDO-Me and SAHA with biotin-coupled near-infrared (NIR) probe hemicyanine via redox-responsive linker thiolactate to enhance the tumor efficacy reduce toxic side effects using both active passive targeting strategies. displayed reactive oxygen species (ROS)- glutathione (GSH)-dependent release of NIR fluorescence two parent drugs. Furthermore, administration caused selective illumination tissues for >24 h, thereby...
A series of novel canthin-6-one (CO) derivatives (8a–l) were designed and synthesized by introducing different amide side chains at the C-2 position, their water solubility, antiproliferative activity, preliminary mechanism investigated. Most compounds displayed high cytotoxicity exhibiting low-micromolar IC50 values against four human cancer cell lines, especially HT29 cells. Meanwhile, solubility active CO was significantly improved. Among these compounds, compound 8h with N-methyl...
A novel hybrid CHC was designed and synthesized by conjugating β-carboline with an important active fragment N -hydroxyacrylamide of histone deacetylase (HDAC) inhibitor amide linkage to enhance antitumor efficacy/potency or even block drug resistance. displayed high antiproliferative effects against drug-sensitive SUMM-7721, Bel7402, Huh7, HCT116 cells drug-resistant Bel7402/5FU IC 50 values ranging from 1.84 3.27 μM, which were two-to four-fold lower than those FDA-approved HDAC SAHA....
Detection of low-abundance biomarkers using mass spectrometry (MS) is often hampered by non-target molecules in biological fluids. In addition, current procedures for sample preparation increase consumption and limit analysis throughput. Here, a simple strategy proposed to construct an antibody-modified target plate high-sensitivity MS detection markers such as insulin, fluids.The was first modified with gold nanoparticle, then functionalized corresponding antibody through chemical...
The accurate diagnosis and effective therapy of malignant tumors is still a challenge owing to its poor prognosis, recurrence, drug resistance. In this study, tumor microenvironment responsive high O2-economic effect nano-theranostic agent GOx@NPs was constructed through the self-assembly GOx CDDO-Fe, which synthesized by coupling natural chemotherapeutic CDDO-Me blocked ferrocene (Fc) with near-infrared (NIR) fluorescence probe hemicyanine (I-CyOH) via redox-responsive linker...
High quality clinical samples are critical for meaningful interpretation of data obtained in both basic and translational medicine. More specifically, optimized pre-analysis handling to bio-sample is crucial avoiding biased analysis a setting. A universally applicable method the evaluation sample therefore great demand.The fingerprint pattern low molecular weight (LMW) peptides sera directly associated with process. Previous studies enrichment/isolation LMW have shown that can be enriched by...
To investigate the clinical significance of color ultrasound, magnetic resonance imaging (MRI), miR-21, and CA199 in diagnosis pancreatic cancer (PC).A total 160 patients with PC admitted to our hospital from April 2018 February 2021 were included group, another 100 benign disease during same period group. Color ultrasound MRI used for examination two groups patients, sensitivity, accuracy, specificity methods preoperative calculated, respectively. A healthy people who underwent physical...
Bacterial artificial chromosome (BAC) libraries have been invaluable tools for the genome-wide genetic dissection of complex organisms. Here, we report construction and characterization a high-redundancy BAC library from very valuable pig breed in China, Wuzhishan miniature ( Sus scrofa ), using its blood cells fibroblasts, respectively. The contains approximately 153,600 clones ordered 40 superpools 10 × 384-deep well microplates. average insert size was estimated to be 152.3 kb,...