A5077298622- biodegradable polymer synthesis and properties
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Electrospun Nanofibers in Biomedical Applications
- Circular RNAs in diseases
- Polymer crystallization and properties
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Clinical practice guidelines implementation
- Supercapacitor Materials and Fabrication
- Artificial Intelligence in Healthcare and Education
- Cardiovascular Effects of Exercise
- Additive Manufacturing and 3D Printing Technologies
- Dermatological and Skeletal Disorders
- Polymer Science and PVC
- Meta-analysis and systematic reviews
- Blood Coagulation and Thrombosis Mechanisms
- Vitamin K Research Studies
- Tissue Engineering and Regenerative Medicine
- Microplastics and Plastic Pollution
- Cardiac Fibrosis and Remodeling
- Parathyroid Disorders and Treatments
- Biofuel production and bioconversion
- Viral Infections and Immunology Research
- Anaerobic Digestion and Biogas Production
Austrian Centre of Industrial Biotechnology (Austria)
2023-2025
BOKU University
2023-2025
Magna Graecia University
2023-2024
The main cause of morbidity and mortality in diabetes mellitus (DM) is cardiovascular complications. Diabetic cardiomyopathy (DCM) remains incompletely understood. Animal models have been crucial exploring DCM pathophysiology while identifying potential therapeutic targets. Streptozotocin (STZ) has widely used to produce experimental both type 1 2 DM (T1DM T2DM). Here, we compared these two for their effects on cardiac structure, function transcriptome. Different doses STZ diet chows were...
In the last two decades, use of phthalates has been restricted worldwide due to their well-known toxicity. Nonetheless, are still widely used for versatility, high plasticization effect, low cost, and lack valuable alternatives. This study presents fully bio-based versatile glycerol trilevulinate plasticizer (GT) that was obtained by valorization levulinic acid. The mild-conditions solvent-free esterification synthesize GT optimized investigating product Fourier transform infrared NMR...
Poly(ethylene terephthalate) (PET) is still a major player in the plastics industry, especially for packaging. Despite attempts to derive its basic components from biological resources, production of terephthalic acid (TPA), one two PET monomers, depends on fossil resources. Alongside traditional polyesters, TPA building block also biodegradable polymers, such as poly(1,4-butylene adipate-co-1,4-butylene (PBAT). Here, PET, PBAT, and real plastic waste were successfully depolymerized using...
Abstract Polylactic acid (PLA) is a widely used biopolymer, but its brittleness and limited biodegradability hinder application as standalone material. To enhance properties, PLA can be compounded with plasticizers, ideally nontoxic from sustainable sources. While phthalates remain the predominant their known harmful effects have led to development of bio‐based alternatives like glycerol trilevulinate (GT). This study investigates plasticizing effect GT on amorphous (aPLA) semi‐crystalline...
Among novel renewable furanoate-based polyesters, poly(pentamethylene 2,5-furandicarboxylate) (PPeF) shows outstanding gas barrier properties and high flexibility. PPeF blending/copolymerization with another well-known bio-based polymer, poly(lactic acid) (PLA), leads to considerably better mechanical of the latter, making it suitable for flexible food packaging applications. In this work, enzymatic depolymerization PLA/PPeF blends different compositions (1, 3, 5, 20, 30, 50 wt % PPeF) a...
Cardiovascular calcification is a multifactorial and complex process involving an array of molecular mechanisms eventually leading to calcium deposition within the arterial walls. This increases stiffness, decreases elasticity, influences shear stress events related increased risk morbidity mortality associated with cardiovascular disease. In numerous in vivo vitro models, warfarin therapy has been shown cause vascular wall. However, exact formation remain largely unknown, although several...
This study focuses on the biochemical characterization of a new hydrolase (Thb) expressed from anaerobic Thermoanaerobacterales, which could be used to improve biogas plant efficiency for plastic waste treatment. The specificity Thb various polyesters, including polyethylene terephthalate (PET), polybutylene adipate (PBAT), succinate (PBS), and polylactic acid (PLA), was compared well-studied cutinase HiC Humicola insolens. Based gravimetric analysis quantification (high-performance liquid...
Background: Three-dimensional cell culture systems hold great promise for bridging the gap between in vitro cell-based model and small animal models to study tissue biology disease. Among 3D systems, stem-cell-derived spheroids have attracted significant interest as a strategy better mimic vivo conditions. Cardiac stem cell/progenitor (CSC)-derived (CSs) provide relevant platform cardiac regeneration. Methods: We compared three different scaffold-free (i) ultra-low attachment plates, (ii)...
Artificial intelligence (AI) is changing our clinical practice. This particularly true in cardiology where the clinician often required to handle a large amount of clinical, biological, and imaging data during decision making. In this context, AI can address need for fast accurate tools while reducing burden on clinicians improving efficiency healthcare systems. With inevitable shift towards more automated efficient systems, patients may benefit from diagnosis tailored treatment. A multitude...