A5040551037- Hemophilia Treatment and Research
- Hematopoietic Stem Cell Transplantation
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Blood Coagulation and Thrombosis Mechanisms
- Blood groups and transfusion
- Chronic Myeloid Leukemia Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Hematological disorders and diagnostics
- Hepatitis C virus research
- CAR-T cell therapy research
- Blood donation and transfusion practices
- Heparin-Induced Thrombocytopenia and Thrombosis
- Renal Transplantation Outcomes and Treatments
- Blood transfusion and management
- T-cell and B-cell Immunology
- Multiple Myeloma Research and Treatments
- Polyomavirus and related diseases
- HIV/AIDS Research and Interventions
McMaster University
2016-2025
Juravinski Cancer Centre
2022-2024
Juravinski Hospital
1982-2024
Hamilton Health Sciences
2000-2018
Health Sciences Centre
2017
Regional Municipality of Niagara
2002-2009
McMaster University Medical Centre
1981-2008
Canadian Blood Services
2002-2006
Canadian Hemophilia Society
1995-2006
Walker (United States)
2006
Febrile, nonhemolytic transfusion reactions are the most frequent adverse to platelets. A number of observations argue against widely held view that these result from interaction between antileukocyte antibodies in recipient and leukocytes platelet product. We sought determine whether substances plasma or cells product cause transfused platelets.We separated standard concentrates into their cellular components then both portions random order. Patients were monitored for during all...
Summary. The objectives of this paper were to study the reported haemophilia A prevalence (per 100 000 males) on a country‐by‐country basis and address following: Does vary by national economies? We collected data for 106 countries from World Federation Hemophilia (WFH) annual global surveys literature. found that varied considerably among countries, even wealthiest countries. high income was 12.8 ± 6.0 (mean SD) whereas it 6.6 4.8 rest world. Within country, there strong trend increasing...
BACKGROUND : Removal of the plasma supernatant from platelets before transfusion is effective in preventing acute reactions to caused by cytokines. Prestorage WBC reduction may be even more at as WBCs are removed and WBC‐derived cytokines do not accumulate this component. This study evaluates effectiveness removal two methods prestorage for platelets. STUDY DESIGN AND METHODS Platelets given adults with hematologic malignancies were randomly allocated one three types: a platelet storage...
BACKGROUND: Recent data suggest that most reactions to platelets are caused by white cell (WBC)‐derived cytokines accumulate in the plasma portion of component during storage. On basis this theory, effectiveness two interventions prevent reactions, poststorage WBC reduction and depletion, were compared. STUDY DESIGN: A multiple crossover design was used, which platelet components for transfusion a patient randomly reduced after storage, or supernatant removed. Adults >17 years age, with...
Summary The Bethesda assay is widely used to monitor the development and progress of Factor VIII:C inhibitors. VIII stability in substrate plasma (normal pool) compromised by pH shift reduction protein concentration. Preliminary study, Verbruggen colleagues (8), suggested a spuriously positive results may result from buffering normal pool with imidazole 7.4 substituting deficient for buffer control incubation mix. These laboratory findings have now been confirmed performance both standard...
The objectives of this article were to study the reported prevalence haemophilia B (HB) on a country-by-country basis and analyse whether HB varied by national economy. is proportion diagnosed, cases in population at specific point time. We collected data for 105 countries from World Federation Hemophilia annual global surveys. Our results showed that considerably among countries, even wealthiest countries. (per 100 000 males) highest income was 2.69 ± 1.61 (mean SD), whereas rest world 1.20...
Summary The present study was initiated to evaluate the safety and efficacy of Haemate-P® (Humate-P® in North America) (anti-hemophilic FVIII/VWF complex [human] dried, pasteurized) dosed ristocetin cofactor units (VWF:RCo) treatment von Willebrand disease (VWD) patients Canada. This retrospective data collection reviewed medical records VWD treated under Canadian Emergency Drug Release Program from November 22, 1991, April 30, 1996. Data accomplished by on-site retrieval source for 97...
PURPOSE To determine whether interferon maintenance therapy improves overall survival and response duration in patients with multiple myeloma who have responded to induction melphalan prednisone. PATIENTS AND METHODS In a multicenter trial, symptomatic clinical stage I II III were registered at diagnosis those melphalan-prednisone (MP) randomized either receive (2 mU/m2) subcutaneously three times per week or no maintenance. MP was discontinued both groups once stable plateau of the...
Summary The European Group for Blood and Marrow Transplantation (EBMT) devised a scoring system to predict survival after allogeneic haematopoietic stem cell transplantation (HSCT) chronic myeloid leukaemia (CML). present International Bone Transplant Registry study of 3211 patients tested the EBMT Risk Score in independent population, investigated value adding other variables, evaluated new risk score specifically phase compared allograft scores with established by Sokal 1984 Hasford 1998...
Sixty-seven patients with newly diagnosed acute nonlymphocytic leukemia (ANLL) who were considered to be poor candidates for treatment cytosine arabinoside (ara-C)/anthracycline antibiotic therapy treated high-dose ara-C (HDara-C) remission induction therapy. Thirty-four of the 67 had a hematologic disorder before developing or history exposure marrow toxins, 23 greater than 70 years old, and 10 medical problems that felt contraindication an anthracycline antibiotic. Forty-two percent...
Abstract The hemophilias are a group of disorders associated with chronic burden morbidity and early mortality. Improvements in these adverse features have been achieved by the use clotting factor concentrates within comprehensive centers specialized care providing home infusion programs. Offsetting effects from transfusion‐transmitted hepatitis HIV infection recent decline. net impact changes merits assessment. To test priori hypotheses that increasing severity VIII deficiency would be an...
Summary. Haemorrhagic manifestations in patients with haemophilia A and B are considered quite similar for comparable level of factor deficiency. We investigated the bleeding frequency usage between HA HB disease severities. collected data on bleeds concentrate utilization over 3 years, from January 2001 to December 2003. Information was gathered home infusion logs recorded by or their parents, treatment records Hemophilia Clinic Hospital Emergency Department. Data were available 58 severe...
Abstract Von Willebrand disease (VWD) is the commonest inherited disorder of hemostasis and majority women with this experience excessive uterine bleeding. Yet very little information available on health‐related quality life (HRQL) in individuals VWD. To test a priori hypotheses that these will have poorer HRQL than members general population, burden morbidity correlate severity VWD, cross‐sectional study was undertaken population‐based cohort regional hemophilia program Ontario, Canada. A...
The life expectancy of individuals with haemophilia was close to that the general population in early 1980s. Since then, has decreased, due transfusion-transmitted virus infections. Deaths were investigated by analysing 2450 records from Canadian Hemophilia Registry, for years 1980-1995. tabulated age, year and cause, compared male calculating standardized mortality ratios (SMRs). median at 1 age calculated various subpopulations impact characteristics assessed survival regression modelling....