A5088214601- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- RNA modifications and cancer
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Protein Structure and Dynamics
- ATP Synthase and ATPases Research
- Supramolecular Chemistry and Complexes
- Metal-Organic Frameworks: Synthesis and Applications
- Histone Deacetylase Inhibitors Research
- Photosynthetic Processes and Mechanisms
- Genetics and Neurodevelopmental Disorders
- Biochemical and Molecular Research
- Helicobacter pylori-related gastroenterology studies
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- Plant Disease Resistance and Genetics
- Covalent Organic Framework Applications
- Protein Degradation and Inhibitors
New York University Abu Dhabi
2019-2020
New York University
2018
Wayne State University
2011-2016
Calixarenes are a common motif in supramolecular chemistry but have rarely been incorporated structurally well-defined covalent 2D materials. Such task is challenging, especially without template, because of the nonplanar configuration and conformational flexibility calixarene ring. Here, we report first-of-a-kind solvothermal synthesis calix[4]arene-based polymer (CX4-NS) that porous, covalent, isolated as few-layer thick (3.52 nm) nanosheets. Experimental theoretical characterization...
Abstract Probing the role of surface structure in electrostatic interactions, we report first observation sequence-dependent dsDNA condensation by divalent alkaline earth metal cations. Disparate behaviors were found between two repeating sequences with 100% AT content, a poly(A)-poly(T) duplex (AA-TT) and poly(AT)-poly(TA) (AT-TA). While AT-TA exhibits non-distinguishable from random-sequence genomic DNA, AA-TT condenses all ions. We characterized these interactions experimentally...
Histone deacetylases (HDAC's) became increasingly important targets for therapy of various diseases, resulting in a pressing need to develop HDAC class- and isoform-selective inhibitors. Class IIa possess only minimal deacetylase activity against acetylated histones, but have several other client proteins as substrates through which they participate epigenetic regulation. Herein, we report the radiosyntheses second generation class IIa–specific radiotracers:...
Most bacteria and all archaea misacylate the tRNAs corresponding to Asn Gln with Asp Glu (Asp-tRNAAsn Glu-tRNAGln).The GatCAB enzyme of most converts misacylated Glu-tRNAGln Gln-tRNAGln in order enable incorporation glutamine during protein synthesis. The conversion process involves intramolecular transfer ammonia between two spatially separated active sites. This study presents a computational analysis putative tunnels that have been suggested describe Molecular dynamics simulations...
The Helicobacter pylori (Hp) Asp-tRNAAsn/Glu-tRNAGln amidotransferase (AdT) plays important roles in indirect aminoacylation and translational fidelity. AdT has two active sites, separate subunits. Kinetic studies have suggested that interdomain communication occurs between these subunits; however, this mechanism is not well understood. To explore domain–domain AdT, we adapted an assay optimized it to kinetically characterize the kinase activity of Hp AdT. This was applied analysis a series...
Abstract Probing the role of surface structure in electrostatic interactions, we report first observation sequence-dependent dsDNA condensation by divalent alkali cations. Disparate behaviors were found between two repeating sequences with 100% AT content, a poly(A)-poly(T) duplex (AA-TT) and poly(AT)-poly(TA) (AT-TA). While AT-TA exhibits non-distinguishable from random-sequence genomic DNA, AA-TT condenses all ions (Mg 2+ , Ca Sr Ba ). We characterized these interactions experimentally...
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to The Kinase Activity of the Helicobacter pyloriAsp-tRNAAsn/Glu-tRNAGln Amidotransferase Is Sensitive Distal Mutations in Its Putative Ammonia TunnelLiangjun Zhao, Sajeewa W. Dewage, Michael J. Bell, Keng-Ming Chang, Shirin Fatma, Nilesh Joshi, Gayathri Silva, G. Andres Cisneros*, and Tamara L. Hendrickson*Cite this: Biochemistry 2013, 52, 13, 2381Publication Date (Web):March 20,...