A5058823611- Asymmetric Synthesis and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Cyclopropane Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Crystallography and molecular interactions
- Radical Photochemical Reactions
- Luminescence and Fluorescent Materials
- Catalytic Alkyne Reactions
- Chemical synthesis and alkaloids
- Advanced Synthetic Organic Chemistry
- Plant and animal studies
- Analytical Chemistry and Sensors
- Organoboron and organosilicon chemistry
- Synthesis and Biological Evaluation
- Synthesis of Indole Derivatives
- Multicomponent Synthesis of Heterocycles
- Traditional and Medicinal Uses of Annonaceae
University of Cagliari
2016-2025
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2016-2025
University of Milan
2024
University of Florence
2022
Universidade Estadual de Campinas (UNICAMP)
2022
Université de Bordeaux
2022
Niigata University
2022
University of L'Aquila
2022
Korea Research Institute of Chemical Technology
2022
Yeungnam University
2022
In the last decade a certain number of new cyclobutane and cyclobutanone synthesis functionalization protocols have been published. Organo- biocatalyzed eco-friendly approaches to cyclobutane-containing molecules developed with interesting results. Also, successful total bioactive compounds drugs recently reported where four membered ring represented key intermediate. Therefore, rising interest in this field represents great point discussion for scientific community, disclosing synthetic...
Regioselective synthesis of 2,4,5- or 3,4,5-trisubstituted 2,3-dihydrofurans has been realized by using donor−acceptor cyclopropanes a Corey ylide reaction with α-sulfenyl-, α-sulfinyl-, α-sulfonylenones. The method allowed straightforward the natural product calyxolane B.
RGB cameras are one of the most relevant sensors for autonomous driving applications. It is undeniable that failures vehicle may compromise task, possibly leading to unsafe behaviors when images subsequently processed by system altered. To support definition safe and robust architectures intelligent systems, in this paper we define failure modes a camera, together with an analysis effects known mitigations. Further, build software library generation corresponding failed feed them six object...
A new protocol for the catalytic asymmetric deprotonation of a phosphine borane using s-BuLi and substoichiometric quantities chiral diamines is reported. The method involves three sequential additions s-BuLi, use (−)-sparteine or (+)-sparteine surrogate facilitates access to P-stereogenic phosphines with opposite configuration. exemplified by synthesis each enantiomer precursors QuinoxP*, trichickenfootphos, Mini-PHOS.
Abstract A catalytic enantioselective synthesis of α‐arylaminocyclobutanones from racemic α‐hydroxycyclobutanone and a selection N ‐alkylanilines has been established, via tandem condensation/keto‐enol tautomerization process reminiscent the Amadori Heyns rearrangements. magnified image
A new solvent-free Brønsted acid catalysed cascade reaction has been established, allowing access to highly substituted tryptamines under mild conditions.
Severe acute respiratory syndrome-related Coronavirus 2 (SARS-CoV-2) has infected more than 762 million people to date and caused approximately 7 deaths all around the world, involving 187 countries. Although currently available vaccines show high efficacy in preventing severe complications patients, number of mutations S proteins current variants is responsible for level immune evasion transmissibility virus reduced effectiveness acquired immunity. In this scenario, development safe...
A novel synthesis of optically active α-arylamino ketones through an organocatalytic enantioselective Amadori–Heyns rearrangement is described.
N-Phenylsulfonyl (S)-proline catalyzes the direct aldol reaction of 3-substituted cyclobutanones and aryl aldehydes in good yield with excellent diastereoselectivity enantioselectivity. This desymmetrization process provides highly functionalized control over three contiguous stereogenic centers.
Abstract An organocatalytic enantioselective synthesis of α‐(benzylamino)cyclobutanones has been achieved by employing a tandem condensation/intramolecular rearrangement/proton transfer reaction and starting from racemic α‐hydroxycyclobutanone selection benzylamines. This sequence afforded the products in good to high yields with moderate enantioselectivities.
Citrazinic acid (CZA) is a weakly fluorescent molecular compound whose optical properties are dependent on aggregation states and chemical environment. This molecule its derivatives have been recently identified as the source of intense blue emission carbon dots obtained from citric with nitrogen source, such ammonia or urea. has strong tendency to aggregate form tautomers largely unexplored. At extreme acidic basic pH values, we observed an "anomalous" response citrazinic acid, attributed...
The cyclopropene scaffold has emerged as a valuable platform in modern synthesis. Here, we present streamlined flow-based approach for the generation of cyclopropenyllithium and its functionalization with various electrophiles single, continuous flow process. This method eliminates need laborious temperature changes cryogenic conditions, significantly reduces process time from starting material to products. Compared traditional batch processes, our enables use single organolithium reagent...
[reaction: see text] Acid-catalyzed ring expansion of chiral cyclopropyl and cyclobutyl derivatives for the synthesis carbo- heterocyclic compounds is reported. The starting materials have been successfully prepared by l-proline-catalyzed direct asymmetric aldol reactions 1-phenylthiocycloalkyl carboxaldehydes with ketones.
The first examples of the asymmetric synthesis P-stereogenic vinylic phospholene boranes are described. synthetic approach is concise and flexible. route involves (i) deprotonation-allylation a dimethyl phosphine borane; (ii) telescoped regioselective deprotonation, paraformaldehyde trapping, hydroxyl group elimination to give diene; (iii) ring-closing metathesis.
Abstract We describe a photochemical reaction using two starting materials, cyclopent‐2‐enone and an alkene, which are transformed in controlled manner via the initial [2+2]‐photocycloaddition adducts into cyclobutene aldehydes (conveniently trapped as stable acetals) or unprecedented angular tricyclic 4:4:4 oxetane‐containing skeletons. These compounds formed through tandem triple cascade processes, respectively. Small libraries of each compound class were prepared, thus suggesting that...
Abstract A practical method for the synthesis of optically active α‐amino cyclobutanones has been developed, via an organocatalytic asymmetric condensation reaction between racemic 2‐hydroxycyclobutanone and chiral N ‐alkyl‐α‐amino acid ester derivatives.
A general strategy for the synthesis of indolyl cyclopropanecarbaldehydes and ketones via a Brønsted acid-catalyzed indole nucleophilic addition/ring-contraction reaction sequence has been exploited. The procedure leads to wide panel cyclopropyl carbonyl compounds in generally high yields with broad substrate scope.
Abstract The first highly enantioselective organocatalytic rearrangement of α‐acyloxy‐β‐keto sulfides to α‐acyloxy thioesters has been developed which provides a number important synthetic building blocks in high yield and with excellent enantioselectivities ( ee : up 92%).
An eco-friendly methodology for the direct α-sulfanylation of ketones has been developed by using diaryl disulfides as sulfanyl source affording ketosulfides in good to excellent yields and high selectivity.
An unprecedented and conceptually novel chiral Brønsted base/Brønsted acid catalytic method for the enantioselective synthesis of α-amino thioesters through a tandem condensation-intramolecular rearrangement-protonation has been developed which provides number important synthetic building blocks in good yield with moderate to enantioselectivities.
A general strategy for the synthesis of arylthio cyclopropyl carbaldehydes and ketones via a Brønsted acid catalyzed arylthiol addition/ring contraction reaction sequence has been exploited. The procedure led to wide panel in generally high yields with broad substrate scope. Mechanistic aspects synthetic applications this were investigated.
An original tandem reaction consisting of a Wittig reaction–ring contraction process between α-hydroxycyclobutanone and phosphonium ylides has been developed. Highly functionalized cyclopropanecarbaldehydes are obtained in good to high yield.