Francesco Secci

ORCID: 0000-0003-0443-2890
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About
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Research Areas
  • Asymmetric Synthesis and Catalysis
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Asymmetric Hydrogenation and Catalysis
  • Synthetic Organic Chemistry Methods
  • Chemical Synthesis and Analysis
  • Chemical Synthesis and Reactions
  • Cyclopropane Reaction Mechanisms
  • Sulfur-Based Synthesis Techniques
  • Oxidative Organic Chemistry Reactions
  • Catalytic C–H Functionalization Methods
  • Synthesis and Catalytic Reactions
  • Crystallography and molecular interactions
  • Radical Photochemical Reactions
  • Luminescence and Fluorescent Materials
  • Catalytic Alkyne Reactions
  • Chemical synthesis and alkaloids
  • Advanced Synthetic Organic Chemistry
  • Plant and animal studies
  • Analytical Chemistry and Sensors
  • Organoboron and organosilicon chemistry
  • Synthesis and Biological Evaluation
  • Synthesis of Indole Derivatives
  • Multicomponent Synthesis of Heterocycles
  • Traditional and Medicinal Uses of Annonaceae

University of Cagliari
2016-2025

Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2016-2025

University of Milan
2024

University of Florence
2022

Universidade Estadual de Campinas (UNICAMP)
2022

Université de Bordeaux
2022

Niigata University
2022

University of L'Aquila
2022

Korea Research Institute of Chemical Technology
2022

Yeungnam University
2022

In the last decade a certain number of new cyclobutane and cyclobutanone synthesis functionalization protocols have been published. Organo- biocatalyzed eco-friendly approaches to cyclobutane-containing molecules developed with interesting results. Also, successful total bioactive compounds drugs recently reported where four membered ring represented key intermediate. Therefore, rising interest in this field represents great point discussion for scientific community, disclosing synthetic...

10.3390/molecules181215541 article EN cc-by Molecules 2013-12-13

Regioselective synthesis of 2,4,5- or 3,4,5-trisubstituted 2,3-dihydrofurans has been realized by using donor−acceptor cyclopropanes a Corey ylide reaction with α-sulfenyl-, α-sulfinyl-, α-sulfonylenones. The method allowed straightforward the natural product calyxolane B.

10.1021/ol0514606 article EN Organic Letters 2005-09-17

RGB cameras are one of the most relevant sensors for autonomous driving applications. It is undeniable that failures vehicle may compromise task, possibly leading to unsafe behaviors when images subsequently processed by system altered. To support definition safe and robust architectures intelligent systems, in this paper we define failure modes a camera, together with an analysis effects known mitigations. Further, build software library generation corresponding failed feed them six object...

10.1109/tdsc.2022.3156941 article EN cc-by IEEE Transactions on Dependable and Secure Computing 2022-03-07

A new protocol for the catalytic asymmetric deprotonation of a phosphine borane using s-BuLi and substoichiometric quantities chiral diamines is reported. The method involves three sequential additions s-BuLi, use (−)-sparteine or (+)-sparteine surrogate facilitates access to P-stereogenic phosphines with opposite configuration. exemplified by synthesis each enantiomer precursors QuinoxP*, trichickenfootphos, Mini-PHOS.

10.1021/jo200708e article EN The Journal of Organic Chemistry 2011-04-21

Abstract A catalytic enantioselective synthesis of α‐arylaminocyclobutanones from racemic α‐hydroxycyclobutanone and a selection N ‐alkylanilines has been established, via tandem condensation/keto‐enol tautomerization process reminiscent the Amadori Heyns rearrangements. magnified image

10.1002/adsc.201301021 article EN Advanced Synthesis & Catalysis 2014-03-12

A new solvent-free Brønsted acid catalysed cascade reaction has been established, allowing access to highly substituted tryptamines under mild conditions.

10.1039/c5cc06855j article EN Chemical Communications 2015-01-01

Severe acute respiratory syndrome-related Coronavirus 2 (SARS-CoV-2) has infected more than 762 million people to date and caused approximately 7 deaths all around the world, involving 187 countries. Although currently available vaccines show high efficacy in preventing severe complications patients, number of mutations S proteins current variants is responsible for level immune evasion transmissibility virus reduced effectiveness acquired immunity. In this scenario, development safe...

10.3390/v16050665 article EN cc-by Viruses 2024-04-24

A novel synthesis of optically active α-arylamino ketones through an organocatalytic enantioselective Amadori–Heyns rearrangement is described.

10.1039/c3cc45278f article EN Chemical Communications 2013-01-01

N-Phenylsulfonyl (S)-proline catalyzes the direct aldol reaction of 3-substituted cyclobutanones and aryl aldehydes in good yield with excellent diastereoselectivity enantioselectivity. This desymmetrization process provides highly functionalized control over three contiguous stereogenic centers.

10.1039/c2ob25813g article EN Organic & Biomolecular Chemistry 2012-01-01

Abstract An organocatalytic enantioselective synthesis of α‐(benzylamino)cyclobutanones has been achieved by employing a tandem condensation/intramolecular rearrangement/proton transfer reaction and starting from racemic α‐hydroxycyclobutanone selection benzylamines. This sequence afforded the products in good to high yields with moderate enantioselectivities.

10.1002/ejoc.201500460 article EN European Journal of Organic Chemistry 2015-06-02

Citrazinic acid (CZA) is a weakly fluorescent molecular compound whose optical properties are dependent on aggregation states and chemical environment. This molecule its derivatives have been recently identified as the source of intense blue emission carbon dots obtained from citric with nitrogen source, such ammonia or urea. has strong tendency to aggregate form tautomers largely unexplored. At extreme acidic basic pH values, we observed an "anomalous" response citrazinic acid, attributed...

10.1021/acsomega.0c00775 article EN publisher-specific-oa ACS Omega 2020-05-05

The cyclopropene scaffold has emerged as a valuable platform in modern synthesis. Here, we present streamlined flow-based approach for the generation of cyclopropenyllithium and its functionalization with various electrophiles single, continuous flow process. This method eliminates need laborious temperature changes cryogenic conditions, significantly reduces process time from starting material to products. Compared traditional batch processes, our enables use single organolithium reagent...

10.1021/acs.orglett.5c01516 article EN cc-by-nc-nd Organic Letters 2025-05-21

[reaction: see text] Acid-catalyzed ring expansion of chiral cyclopropyl and cyclobutyl derivatives for the synthesis carbo- heterocyclic compounds is reported. The starting materials have been successfully prepared by l-proline-catalyzed direct asymmetric aldol reactions 1-phenylthiocycloalkyl carboxaldehydes with ketones.

10.1021/ol063084a article EN Organic Letters 2007-01-12

The first examples of the asymmetric synthesis P-stereogenic vinylic phospholene boranes are described. synthetic approach is concise and flexible. route involves (i) deprotonation-allylation a dimethyl phosphine borane; (ii) telescoped regioselective deprotonation, paraformaldehyde trapping, hydroxyl group elimination to give diene; (iii) ring-closing metathesis.

10.1021/ol303253h article EN Organic Letters 2012-12-21

Abstract We describe a photochemical reaction using two starting materials, cyclopent‐2‐enone and an alkene, which are transformed in controlled manner via the initial [2+2]‐photocycloaddition adducts into cyclobutene aldehydes (conveniently trapped as stable acetals) or unprecedented angular tricyclic 4:4:4 oxetane‐containing skeletons. These compounds formed through tandem triple cascade processes, respectively. Small libraries of each compound class were prepared, thus suggesting that...

10.1002/anie.201803571 article EN Angewandte Chemie International Edition 2018-04-12

Abstract A practical method for the synthesis of optically active α‐amino cyclobutanones has been developed, via an organocatalytic asymmetric condensation reaction between racemic 2‐hydroxycyclobutanone and chiral N ‐alkyl‐α‐amino acid ester derivatives.

10.1002/ajoc.201400020 article EN Asian Journal of Organic Chemistry 2014-04-01

A general strategy for the synthesis of indolyl cyclopropanecarbaldehydes and ketones via a Brønsted acid-catalyzed indole nucleophilic addition/ring-contraction reaction sequence has been exploited. The procedure leads to wide panel cyclopropyl carbonyl compounds in generally high yields with broad substrate scope.

10.1021/acs.orglett.9b02617 article EN Organic Letters 2019-09-06

Abstract The first highly enantioselective organocatalytic rearrangement of α‐acyloxy‐β‐keto sulfides to α‐acyloxy thioesters has been developed which provides a number important synthetic building blocks in high yield and with excellent enantioselectivities ( ee : up 92%).

10.1002/adsc.201000376 article EN Advanced Synthesis & Catalysis 2010-11-16

An eco-friendly methodology for the direct α-sulfanylation of ketones has been developed by using diaryl disulfides as sulfanyl source affording ketosulfides in good to excellent yields and high selectivity.

10.1039/c5ra17913k article EN RSC Advances 2015-01-01

An unprecedented and conceptually novel chiral Brønsted base/Brønsted acid catalytic method for the enantioselective synthesis of α-amino thioesters through a tandem condensation-intramolecular rearrangement-protonation has been developed which provides number important synthetic building blocks in good yield with moderate to enantioselectivities.

10.1039/c1ob06623d article EN Organic & Biomolecular Chemistry 2011-10-25

A general strategy for the synthesis of arylthio cyclopropyl carbaldehydes and ketones via a Brønsted acid catalyzed arylthiol addition/ring contraction reaction sequence has been exploited. The procedure led to wide panel in generally high yields with broad substrate scope. Mechanistic aspects synthetic applications this were investigated.

10.1039/c8cc07571a article EN Chemical Communications 2018-01-01

An original tandem reaction consisting of a Wittig reaction–ring contraction process between α-hydroxycyclobutanone and phosphonium ylides has been developed. Highly functionalized cyclopropanecarbaldehydes are obtained in good to high yield.

10.1021/acs.orglett.9b02690 article EN Organic Letters 2019-09-13
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