A5103108153- Developmental Biology and Gene Regulation
- Hedgehog Signaling Pathway Studies
- Microtubule and mitosis dynamics
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Genetic and Kidney Cyst Diseases
- Acute Myeloid Leukemia Research
- Cell death mechanisms and regulation
- Ocular Disorders and Treatments
- Congenital heart defects research
- Genomic variations and chromosomal abnormalities
- MicroRNA in disease regulation
St. Jude Children's Research Hospital
2020-2023
Imaging Center
2020-2023
Morphogens function in concentration-dependent manners to instruct cell fate during tissue patterning. The cytoneme morphogen transport model posits that specialized filopodia extend between morphogen-sending and responding cells ensure appropriate signaling thresholds are achieved. How morphogens transported along deployed from cytonemes, how quickly a cytoneme-delivered, receptor-dependent signal is initiated, whether these processes conserved across phyla not known. Herein, we reveal the...
The bone marrow microenvironment (BME) drives drug resistance in acute lymphoblastic leukemia (ALL) through leukemic cell interactions with (BM) niches, but the underlying mechanisms remain unclear. Here, we show that interaction between ALL and mesenchymal stem cells (MSCs) integrin β1 induces an epithelial-mesenchymal transition (EMT)-like program MSC-adherent cells, resulting enhanced survival. Moreover, single-cell RNA sequencing analysis of ALL-MSC co-culture identifies a hybrid cluster...
Abstract Progressive ventricular enlargement, a key feature of several neurologic and psychiatric diseases, is mediated by unknown mechanisms. Here, using murine models 22q11-deletion syndrome (22q11DS), which associated with schizophrenia in humans, we found progressive enlargement lateral third ventricles deceleration ciliary beating on ependymal cells lining the walls. The cilia-beating deficit observed brain slices vivo caused elevated levels dopamine receptors (Drd1), are expressed...
Summary Morphogens function in concentration-dependent manners to instruct cell fate during tissue patterning. Molecular mechanisms by which these signaling gradients are established and reinforced remain enigmatic. The cytoneme transport model posits that specialized filopodia extend between morphogen-sending responding cells ensure appropriate signal activation thresholds achieved across developing tissues. How morphogens transported along deployed from cytonemes is not known. Herein we...