A5000802354- Maternal and fetal healthcare
- Trauma and Emergency Care Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Maternal and Perinatal Health Interventions
- Cervical Cancer and HPV Research
- Airway Management and Intubation Techniques
- Pregnancy and preeclampsia studies
- AI in cancer detection
- Sepsis Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Healthcare professionals’ stress and burnout
- Innovations in Medical Education
- Emergency and Acute Care Studies
- Head and Neck Cancer Studies
- Empathy and Medical Education
- Tracheal and airway disorders
- Grief, Bereavement, and Mental Health
- Colorectal and Anal Carcinomas
- Health Systems, Economic Evaluations, Quality of Life
- Molecular Biology Techniques and Applications
- Patient-Provider Communication in Healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Disaster Response and Management
Cardiff and Vale University Health Board
2012-2025
National Health Service Wales
2024-2025
University Hospital of Wales
2010-2025
Cardiff University
2011-2024
Keele University
2024
Shrewsbury and Telford Hospital NHS Trust
2024
University of Aberdeen
2024
Primary Health Care
2024
University of Oxford
2024
Queen Elizabeth University Hospital
2016-2024
Haemostatic impairment may exacerbate postpartum haemorrhage (PPH). Previously, we described a distinct coagulopathy, associated with multiple causes of PPH including placental abruption and amniotic fluid embolus, termed acute obstetric coagulopathy (AOC). AOC is characterised by very high plasmin/antiplasmin complexes rapid depletion functional fibrinogen factor (F)V. To determine mechanisms underlying investigated plasma from 12 women (here defined as >25,000 ng/mL) 21 severe...
It is universally accepted that high-risk human papillomavirus (HR-HPV) the cause of cervical dysplasia and cancer. More recently, it has been shown HPV also a marker clinical outcome in oropharyngeal However, contemporary information lacking on both prevalence infection vulvar cancer (VSCC), its precursor lesion, intraepithelial neoplasia (VIN) influence HPV-status prognosis this malignancy. We have conducted detailed population-based study to examine rates progression VIN VSCC,...
This study aimed to determine whether breastfeeding duration and the timing of solid food were independently associated with being overweight or obese in early childhood. Subjects 953 children participating Study Mothers Infants Life Events Affecting Oral Health (SMILE) birth cohort study, based Adelaide, Australia. Socio-demographic information data on age introduction collected at birth, 3, 4, 6, 12, 24 months via mailed online questionnaires completed by mothers. The weight height...
Abstract Background Visual estimation of blood loss following delivery often under-reports actual bleed volume. To improve accuracy, quantitative measurement was introduced for all births in the 12 hospitals providing maternity care Wales. This intervention incorporated into a quality improvement programme (Obstetric Bleeding Strategy Wales, OBS Cymru). We report incidence postpartum haemorrhage Wales over 1-year period using measurement. Methods prospective, consecutive cohort included...
Postpartum haemorrhage (PPH) is a major cause of maternal morbidity and mortality its incidence increasing in many countries despite management guidelines. A national quality improvement programme called the Obstetric Bleeding Strategy for Wales (OBS Cymru) was introduced all obstetric units Wales. The aim to reduce moderate PPH (1000 mL) progressing massive (> 2500 need red cell transfusion.A care bundle into 12 included women giving birth 2017 2018 (n = 61,094). prompted: universal risk...
Background: The association between physician self-reported empathy and burnout has been studied in the past with diverse findings. We aimed to determine among United States emergency medicine (EM) physicians using a novel combination of tools for validation. Methods: This was prospective single-center observational study. Data were collected from EM physicians. From December 1, 2018 January 31, 2019, we used Jefferson scale (JSE) assess Copenhagen inventory (CBI) burnout. divided into...
In this study we use artificial intelligence (AI) to categorise endometrial biopsy whole slide images (WSI) from digital pathology as either “malignant”, “other or benign” “insufficient”. An is a key step in diagnosis of cancer, biopsies are viewed and diagnosed by pathologists. Pathology increasingly digitised, with slides on screens rather than through the lens microscope. The availability these driving automation via application AI. A model that classifies manner proposed would allow...
The trade in primates as pets is a global enterprise and access to the Internet has increased, so too of live online. While quantifying primate physical markets relatively straightforward, limited insights have been made into via Internet. Here we followed three-pronged approach estimate prevalence ease purchasing online countries with different socioeconomic characteristics. We first conducted literature review, which found that Malaysia, Thailand, USA, Ukraine, South Africa, Russia stood...
Abstract Purpose: We sought to identify the genomic abnormalities in squamous cell carcinomas (SCC) arising ovarian mature cystic teratoma (MCT), a rare gynecological malignancy of poor prognosis. Experimental design: performed copy number, mutational state, and zygosity analysis 151 genes SCC MCT (n = 25) using next-generation sequencing. The presence high-/intermediate-risk HPV genotypes was assessed by quantitative PCR. Genomic events were correlated with clinical features outcome....
Background Post-partum haemorrhage (PPH) is one of the leading causes maternal mortality and morbidity worldwide. The Obstetric Bleeding Strategy (OBS) care bundle for PPH management was adopted into Welsh national guidelines in 2019 (as OBS Cymru), currently being implemented across 36 sites rest UK through stepped-wedge cluster randomised controlled trial. We conducted a qualitative evaluation five years after its adoption to inform plans optimising implementation UK. Methods ethnographic...
Background Postpartum haemorrhage (PPH) contributes to substantial maternal morbidity. Research into PPH has led improvements in care which have been incorporated the Obstetric Bleeding Strategy for Wales. Intervention A national quality improvement team supported local teams implementing multiple interventions including risk assessment, objective measurement of blood loss, multiprofessional assessment (at bedside at 1000 mL loss) and point-of-care (POC) testing coagulation guide product...
Telehealth and Medicine Today (THMT) editors members of the International Society for Telemedicine eHealt (ISfTeH) this face-paced conversation. Hear frontline experts discuss real world experiences opinions about AI, improving patient care, operational efficiency within healthcare sector. Topics that will be discussed conversation include are: How to move beyond pilot purgatory focus on what really matters - outcomes. Drawing real-world examples from community-based Practical strategies...