A5011776550- Blood groups and transfusion
- Platelet Disorders and Treatments
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Autoimmune Bullous Skin Diseases
- Ethics and Legal Issues in Pediatric Healthcare
- Biomedical Ethics and Regulation
- T-cell and B-cell Immunology
- Blood transfusion and management
- Reproductive System and Pregnancy
- Organ Donation and Transplantation
- Complement system in diseases
- Potassium and Related Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinal and Optic Conditions
- Immune cells in cancer
- Renal Diseases and Glomerulopathies
- Nutrition and Health in Aging
- Acute Lymphoblastic Leukemia research
- Retinal Diseases and Treatments
- Cancer-related gene regulation
- Immune Response and Inflammation
Universitätsklinikum Erlangen
2025
At Bristol
2020-2025
University Hospitals Bristol NHS Foundation Trust
2017-2023
NHS Blood and Transplant
2021-2022
University Hospitals Bristol and Weston NHS Foundation Trust
2021
National Health Service
2020
Great Western Hospital
2019
University of Maryland, Baltimore County
2017
University of Bonn
2012
Vienna Biocenter
2001
β-Catenin is essential for E-cadherin–mediated cell adhesion in epithelial cells, but it also forms nuclear complexes with high mobility group transcription factors. Using a mouse mammary system, we have shown previously that conversion of cells to fibroblastoid phenotype (epithelial-mesenchymal transition) involves downregulation E-cadherin and upregulation β-catenin transcriptional activity. Here, demonstrate transient expression exogenous both arrested growth or caused apoptosis,...
// Lucas A. Horn 1,* , Nicholas G. Ciavattone 2,* Ryan Atkinson 1 Netsanet Woldergerima Julia Wolf Virginia K. Clements Pratima Sinha Munanchu Poudel and Suzanne Ostrand-Rosenberg Department of Biological Sciences, University Maryland Baltimore County, Baltimore, MD, USA 2 Marlene Stewart Greenebaum Comprehensive Cancer Center, Maryland, * These authors contributed equally to this project Correspondence to: Ostrand-Rosenberg, email: Keywords : tumor-induced immune suppression, checkpoint...
ABSTRACT Autologous stem cell transplant (ASCT) requires the collection of hematopoietic progenitor cells, commonly by apheresis (HPC‐A). These CD34+ cells can be mobilized using Granulocyte Colony Stimulating Factor (G‐CSF) only or chemomobilization plus G‐CSF. Both methods may additionally include Plerixafor. The emergence COVID‐19 led to recommendations for preferential G‐CSF mobilization. To assess impact this recommendation on HPC‐A harvesting, we analyzed data from NHS Blood and...
Acute thrombotic thrombocytopenic purpura (TTP) is a life-threatening emergency and plasma exchange (PEX) the initial treatment shown to reduce acute mortality.To compare current practice in United Kingdom (UK) against standards set out 2012 British Society of Haematology guideline, better understand issues affecting prompt initiation PEX.The trainee research network HaemSTAR conducted retrospective nationwide review adults presenting UK hospitals with first episode TTP.Data on 148 patients...
Summary Regulatory B (Breg) cells are potentially implicated in the pathogenesis of immune thrombocytopenia (ITP). We analysed a prospective cohort newly diagnosed steroid naïve ITP patients enrolled multicentre FLIGHT trial and found that numbers Bregs their peripheral blood were similar to healthy controls. In contrast, Breg significantly reduced treated with systemic immunosuppression (glucocorticoids or mycophenolate mofetil). also demonstrate glucocorticoid treatment impairs...
Extra-corporeal photopheresis (ECP) requires anticoagulation to prevent circuit clotting. Unfractionated heparin (UFH) is currently the only anticoagulant licensed for ECP system in use United Kingdom (UK). Acid citrate dextrose-A (ACD-A) preferred most other apheresis procedures. Anecdotal evidence suggested variability practice across UK with some providers using off-label ACD-A.We developed a survey together Photopheresis Society establish current practice.This was distributed all 17...