A5033613894- Carbohydrate Chemistry and Synthesis
- Drug Transport and Resistance Mechanisms
- Enzyme Catalysis and Immobilization
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Tannin, Tannase and Anticancer Activities
- Asymmetric Hydrogenation and Catalysis
- Computational Drug Discovery Methods
- Natural Antidiabetic Agents Studies
- Click Chemistry and Applications
- Plant biochemistry and biosynthesis
- Microbial Natural Products and Biosynthesis
- Synthesis of Organic Compounds
- Natural product bioactivities and synthesis
- Cancer therapeutics and mechanisms
- Nanoparticle-Based Drug Delivery
- Synthesis and Biological Evaluation
- Synthesis and properties of polymers
- Nanoplatforms for cancer theranostics
- Catalysis for Biomass Conversion
- Organoboron and organosilicon chemistry
Tampere University
2020-2021
Maa- ja Vesitekniikan Tuki Ry
2019
The development of multidrug resistance (MDR) is a major cause failure in cancer chemotherapy. Several abietane diterpenes with antitumoral activities have been isolated from Plectranthus spp. such as 6,7-dehydroroyleanone (DHR, 1) and 7α-acetoxy-6β-hydroxyroyleanone (AHR, 2). royleanone derivatives were prepared through hemisynthesis natural compounds 1 2 to achieve small library products enhanced anti-P-glycoprotein activity. Nonetheless, some tend be unstable. Therefore, reason lack...
Cancer is among the leading causes of death worldwide. One most challenging obstacles in cancer treatment multidrug resistance (MDR). Overexpression P-glycoprotein (P-gp) associated with MDR. The growing incidence and development MDR drive search for novel more effective anticancer drugs to overcome problem. Royleanones are natural bioactive compounds frequently found Plectranthus spp. cytotoxic diterpene 6,7-dehydroroyleanone ( 1 ) main component P. madagascariensis (Pers.) Benth. essential...
Aim: Quinic acid (QA) is a cyclic polyol exhibiting anticancer properties on several cancers. However, potential role of QA derivatives against glioblastoma not well established. Methodology & results: Sixteen novel and QA-16 encapsulated poly (lactic-co-glycolic acid) nanoparticles (QA-16-NPs) were screened for their anti-glioblastoma effect using standard cell molecular biology methods. Presence tertiary hydroxy silylether groups in the lead compound identified antitumor activity. have 90%...
The O,O-silyl group migrations on a quinic acid-derived cyclitol have been studied, and the ease of migration was observed to be dependent silicon substituents reaction conditions. Conditions were found improve formation main isomer during that could integrated into formal synthesis vitamin D receptor modulator VS-105 in first total metabolite from African ant Crematogaster nigriceps.
The installation of vicinal mesylate and silyl ether groups in a quinic acid derivative generates system prone for stereoselective borane-catalyzed hydrosilylation through siloxonium intermediate. diversification the reaction conditions allowed construction different defunctionalized fragments foreseen as useful synthetic fragments. selectivity was rationalized on basis deuteration experiments computational studies.