A5022565845- Pluripotent Stem Cells Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Tissue Engineering and Regenerative Medicine
- Cancer therapeutics and mechanisms
- Mesenchymal stem cell research
- Bioactive Compounds and Antitumor Agents
- Medical Research and Treatments
- Electron Spin Resonance Studies
- CRISPR and Genetic Engineering
- Endoplasmic Reticulum Stress and Disease
- Selenium in Biological Systems
- Animal Genetics and Reproduction
- Parkinson's Disease Mechanisms and Treatments
- Wnt/β-catenin signaling in development and cancer
- Calcium signaling and nucleotide metabolism
- Cancer-related molecular mechanisms research
- Synthesis and biological activity
- Folate and B Vitamins Research
- Nanoparticles: synthesis and applications
- Redox biology and oxidative stress
- Autophagy in Disease and Therapy
- Neurological disorders and treatments
- Chemotherapy-induced organ toxicity mitigation
- Biochemical and biochemical processes
- 3D Printing in Biomedical Research
Tabriz University of Medical Sciences
2018-2024
Hamedan University of Medical Sciences
2021-2024
β-LAPachone (B-LAP) is a naphthoquinone that possesses antioxidant properties. In the present investigation, protective effect of B-LAP against doxorubicin (DOX)-induced cardiotoxicity was examined in mice. Thirty-five mice were divided into 5 groups: control group, (5 mg/kg) DOX (15 DOX+B-LAP (2.5 group and group. administered orally for 14 days experimental period. A single dose injected intraperitoneally on day 3. Cardiac function, histoarchitecture, indices oxidative stress circulating...
Background: Various effects, such as oxidative stress and the induction of apoptotic genes, have been reported regarding selenium nanoparticles (SeNPs) on human cell lines. Objectives: This report studied effects SeNPs SW480, a colon cancer line. Methods: The SW480 lines were investigated using MTT assay, measurement reactive oxygen species (ROS) activities enzymes, study Bax, Bcl2, P53 gene expression. Results: cells treated with showed an increase in expression Bax P53, along decrease Bcl2...
Cisplatin is an effective antineoplastic agent; its clinical utility, however, limited by a few salient toxic side effects like nephrotoxicity. This study aimed to determine the potential protective of tangeretin, citrus-derived flavonoid, against renal tubular cell injury in cisplatin-induced toxicity rats.Tangeretin was injected intraperitoneally at 2.5 and 5 mg/kg doses for 10 days, single dose cisplatin (8 mg/kg) on 7th day. Tests kidney function tissues urine together with oxidative...
Non-small cell lung cancer is the most common type of cancer, accounting for more than 80% this tumor. Ubiquitin-specific protease (USP) 14 one 100 deubiquitinating enzymes that overexpressed in and has been validated as a therapeutic target. The aim study to determine whether accumulation ubiquitinated proteins results endoplasmic reticulum (ER) stress-mediated autophagy. To inhibit USP-14, A549 cells were treated with USP-14 siRNA IU1-47 (20 μM). protein level, mRNA expression, cycle...
Cell adhesion, as dynamic interactions between cell-cell and cell-matrix, has an essential role in cancer cell migration. Integrins membrane receptors are involved adhesion signal transduction. Aberrant expression of integrins is associated with the adhesion. Targeting process migration could be helpful to prevent metastasis. Amygdalin a cyanoglycoside compound anti-cancer properties, while its effect on not completely clear. The cytotoxic amygdalin breast lines (MCF-7 MDA-MB- 231) human...
Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. Through the acid acylation process, this enzyme orchestrates post-translational modifications to proteins involved in cell development and differentiation. In study, we used biochemical methods, immunostaining, covalent labeling evaluate whether a small molecule modulating unsaturated acids can influence early endodermal differentiation human-induced pluripotent stem cells (iPSCs).The hiPSCs were...
Abstract Doxorubicin (DOX) is a widely used antineoplastic drug, but its clinical use limited by significant toxicities, such as hepatotoxicity. In this study, we evaluated the effects of β‐lapachone (β‐LAP), natural quinone‐containing compound, in mouse model DOX‐induced β‐LAP was orally administered at 1.25, 2.5, and 5 mg/kg for 4 days, single dose DOX (20 mg/kg) injected intraperitoneally on second day. Histopathological changes, liver function markers, antioxidant inflammatory markers...
Abstract Porcupine (Porcn) enzyme plays an essential role in Wnt signaling activation. Stearoyl‐CoA desaturase‐1 (SCD1) is required to provide Porcn substrates. The aim of this study was determine the effect a novel inhibitor on fate human embryonic stem cells (hESCs) and reliance SCD1 activity. hESCs were cultured feeder layer or Matrigel‐coated plates. Small molecules WNT974 (LGK‐974) CAY10566 used inhibit activity, respectively. We assessed inhibition viability, expression targets,...
Abstract In type 2 diabetes, dyslipidemia and increased serum free fatty acids (FFAs) exacerbate the development of disease through a negative effect on insulin secretion. Adipose‐derived mesenchymal stem cells (AdMSCs) play key role in regenerative medicine, these can potentially be applied as novel therapeutic resources treatment diabetes. this study, AdMSCs were treated with diabetic or nondiabetic FFAs isolated from women menopausal age. Serum analyzed using gas–liquid chromatography....
<title>Abstract</title> Background Selenium nanoparticles (SeNPs) have special applications in biochemistry and physics that enable various effects, such as oxidative stress or antioxidant activity. In the present study, effect of SeNPs on SW480 cell lines via MTT assay, determination ROS enzymes activities, gene expression Bax, Bcl2, P53 were studied. Results The results showed levels increased after 24 hours treatment with selected concentrations. Moreover, activities SOD, CAT, GPx...
This study explores the role of LINC00839 and its potential interaction with miR-195-5p/cyclin E1 (CCNE1) axis in oral squamous cell carcinoma (OSCC). Using The Cancer Genome Atlas, we analyzed lncRNA, miRNA, mRNA sequencing data for OSCC. Different online tools were applied to detect lncRNA-related miRNAs their target mRNAs, forming a lncRNA/miRNA/mRNA axis. Co-expression analysis determined correlation between lncRNA expression. Afterward, protein-protein network functional enrichment...
Abstract Background: Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. This enzyme can orchestrate posttranslational modification proteins involved in the development and differentiation cells through acid acylation process. In this study, we evaluated whether a small molecule modulating unsaturated acids influences early endodermal induced pluripotent stem cells, using biochemical methods immunostaining. Methods: The hiPSCs were cultured an...