A5101569947- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Fungal Biology and Applications
- Anorectal Disease Treatments and Outcomes
- Chemokine receptors and signaling
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Pharmacological Effects of Natural Compounds
- Diverticular Disease and Complications
- Intraperitoneal and Appendiceal Malignancies
- Traditional Chinese Medicine Analysis
- Appendicitis Diagnosis and Management
- Genomics, phytochemicals, and oxidative stress
- Hernia repair and management
- Phytochemistry and Biological Activities
- Full-Duplex Wireless Communications
- Immunotherapy and Immune Responses
- Inflammatory Biomarkers in Disease Prognosis
- Chemotherapy-related skin toxicity
- Endoplasmic Reticulum Stress and Disease
- Ginseng Biological Effects and Applications
- Cell Adhesion Molecules Research
- Gastrointestinal disorders and treatments
Krirk University
2025
Chiayi Chang Gung Memorial Hospital
2013-2022
Weatherford College
2022
Chang Gung University
2011-2021
Tao Yuan General Hospital
2021
Colon and Rectal Surgery Associates
2021
Chang Gung Memorial Hospital
2005-2020
Memorial Hospital of South Bend
2004-2014
Hericium erinaceus, an edible mushroom, has been demonstrated to potentiate the effects of numerous biological activities. The aim this study was investigate whether H. erinaceus mycelium could act as anti-inflammatory agent bring about neuroprotection using a model global ischemic stroke and mechanisms involved. Rats were treated with its isolated diterpenoid derivative, erinacine A, after ischemia reperfusion brain injuries caused by occlusion two common carotid arteries. production...
Stromal cell-derived factor-1 (SDF-1) (CXC chemokine ligand-12)/CXC receptor 4 (CXCR4) is involved in the carcinogenesis of human gastric cancer, where it stimulates angiogenesis and favors metastasis tumor cells to distant organs. In addition, resistin suggested be an important link between obesity development cancer. Resistin has identified as player inflammatory responses, emerged a mediator inflammation-associated A limited number studies have investigated association SDF-1 with Herein,...
Abstract Background Hericium erinaceus is an edible mushroom; its various pharmacological effects which have been investigated. This study aimed to demonstrate whether efficacy of oral administration H. mycelium (HEM) and isolated diterpenoid derivative, erinacine A, can act as anti-neuroinflammatory agent bring about neuroprotection using MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model Parkinson’s disease, results in motor disturbances, addition elucidating the mechanisms...
Baicalein is the flavonoids with multiple pharmacological activities. The aim of our study was to investigate effects baicalein on colorectal cancer (CRC) and recognize targets treatment. To better understand baicalein's target, proteomic approaches were used purify identify protein substrates using 2D difference gel electrophoresis (2D SDS‐PAGE) elucidate proteins differential display. Results from this that treatment CRC cells results in reduced cell proliferation. As a result, displays...
Hericium erinaceus, a valuable pharmaceutical and edible mushroom, contains potent bioactive compounds such as H. erinaceus mycelium (HEM) its derived ethanol extraction of erinacine A, which have been found to regulate physiological functions in our previous study. However, HEM or A with post-treatment regimens also shows effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, but mechanisms remain unknown. By using annexin-V–fluorescein-isothiocyanate...
Abstract Although JC virus (JCV), a human polyomavirus, has been detected in colon cancers, the association between JCV and cancer remains controversial. In Taiwan, prevalence of infection patients not reported. Thus, purpose this study was to investigate cancers Taiwan. Formalin‐fixed, paraffin‐embedded tissues from 22 were examined study. Nested PCR performed detect viral genomic DNA. The product nested flanking regulatory region sequenced further. Viral large tumor protein, LT, late...
Obesity has been shown to be associated with the risk of colorectal cancer (CRC). Adipokines produced by adipose tissue are linked some malignancies, including CRC. Visfatin is an adipokine a biomarker CRC malignant potential. In addition, stromal cell-derived factor-1 (SDF-1) reported play role in progression. Although relationship between visfatin and established, underlying mechanism not clarified. We investigated molecular governing interaction stimulation SDF-1 expression human cell...
Erinacine A, a major active component of diterpenoid derivative isolated from Hericium erinaceus mycelium, has been demonstrated to exert anticancer effects. Herein, we present an investigation the molecular mechanism erinacine A induction associated with cancer cells' aggressive status and death. proteomic approach was used purify identify differentially expressed proteins following treatment its action in apoptotic targets A. Our results demonstrate that HCT-116 DLD-1 cells increased cell...
Machine learning has emerged as a core technology in domains such big data, the Internet of Things (IoT), and cloud computing. The training machine models typically requires extensive datasets, often gathered through crowdsourcing methods. These datasets frequently contain significant amounts private information, including personally identifiable information (e.g., phone numbers, identification numbers) sensitive data financial, medical, health records). efficient cost-effective protection...
Caffeic acid phenethyl ester (CAPE), a component of propolis, is reported to possess anti-inflammatory, anti-bacterial, anti-viral, and anti-tumor activities. Previously, our laboratory demonstrated the in vitro vivo bioactivity CAPE addressed role p53 p38 mitogen-activated protein kinase (MAPK) pathway regulating CAPE-induced apoptosis C6 glioma cells.C6 cancer cell lines were exposed doses CAPE; DNA fragmentation MAPKs NGF/P75NTR levels then determined. SMase activity ceramide content...
Erinacine A, which is one of the major bioactive diterpenoid compounds extracted from cultured mycelia H. erinaceus, displays great antitumorigenic activity. However, molecular mechanisms underlying erinacine A inducing cancer cell apoptosis in colorectal (CRC) remain unclear. This study found that treatment with not only triggers activation extrinsic pathways (TNFR, Fas, FasL, and caspases) but also suppresses expression antiapoptotic molecules Bcl-2 Bcl-XL via a time-dependent manner DLD-1...
The stromal cell-derived factor-1 (SDF-1)/CXC receptor 4 (CXCR4) axis plays an important role in tumor angiogenesis and invasiveness colorectal cancer (CRC) progression. In addition, metastatic CRC remains one of the most difficult human malignancies to treat because its chemoresistant behavior. However, mechanism by which correlation occurs between CXCR4 clinical response chemotherapy unknown. We generated cells with increasing doses oxaliplatin (OXA) 5-Fluorouracil (5FU) develop resistance...
The CC chemokine receptor 6 (CCR6) and its ligand CCL20 are involved in human colorectal cancer (CRC) carcinogenesis can promote the progression of CRC. In addition, interleukin-17 (IL-17), produced by a T cell subset named "Th17," has been identified as an important player inflammatory responses, emerged mediator inflammation-associated cancer. However, relevance IL-17 development CRC still remains to be explored. This study aimed investigate effect on migration cells. Human HCT-116 cells...
Abstract Background The CXC chemokine ligand 12 (CXCL12)/stromal cell-derived factor-1 (SDF-1) and receptor 4 (CXCR4) axis is involved in human colorectal cancer (CRC) carcinogenesis can promote the progression of CRC. Interaction between CRC cells endothelium a key event tumor progression. aim this study was to investigate effect SDF-1 on adhesion cells. Methods Human DLD-1 were used intercellular molecule-1 (ICAM-1) expression cell endothelium. Results treatment induced increased level...
A high level of serum resistin has recently been found in patients with a number cancers, including colorectal cancer (CRC). Hence, may play role CRC development. Fulvic acid (FA), class humic substances, possesses pharmacological properties. However, the effect FA on pathophysiology remains unclear. The aim this study was to investigate endothelial adhesion and determine whether elicits an antagonistic mechanism neutralize effect. Human HCT-116 (p53-negative) SW-48 (p53-positive) cells...