A5040431905- Microfluidic and Capillary Electrophoresis Applications
- Electrowetting and Microfluidic Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
Technische Universität Braunschweig
2021-2025
Two-phase biocatalysis in batch reactions often suffers from inefficient mass transfer, inconsistent reaction conditions, and enzyme inactivation issues. Microfluidics offer uniform controlled environments ensuring better reproducibility enable efficient, parallel processing of many small-scale reactions, making more scalable. In particular, the use microfluidic droplets can increase interfacial area between two phases therefore also rates. For these reasons, slug flow has been extensively...
This Perspective discusses the literature related to two-phase biocatalysis in microfluidic droplets. Enzymes used as catalysts are generally less stable organic media than their native aqueous environments; however, chemical and pharmaceutical compounds often insoluble water. The use of aqueous/organic provides a solution this problem has therefore become standard practice for multiple biotransformations. In batch, is limited by mass transport, limitation that can be overcome with systems....