The capacity of adult mammals to regenerate sensory hair cells is not well defined. To explore early steps in this process, we examined reactivation a transiently expressed developmental gene, Atoh1 , mouse utricles after neomycin-induced cell death culture. Using an adenoviral reporter for enhancer, found that transcription activated some progenitors (supporting cells) 3 d neomycin treatment. By 18 neomycin, the number with transcriptional activity increased significantly, but few acquired...

Objectives To develop a version of the Montreal Cognitive Assessment (MoCA) to be administered severely hearing impaired (HI‐MoCA), and assess its performance in two groups cognitively intact adults over age 60. Study Type Test development followed by prospective subject recruitment. Methods The MoCA was converted into timed PowerPoint (Microsoft Corp., Redmond, WA) presentation, verbal instructions were visual instructions. Two subjects 60 recruited. All passed screening questionnaires...

Background: The proton charge radius extracted from recent muonic hydrogen Lamb shift measurements is significantly smaller than that atomic and electron scattering measurements. discrepancy has become known as the puzzle.Purpose: In an attempt to understand discrepancy, we review high-precision results Mainz, Jefferson Lab, Saskatoon, Stanford.Methods: We make use of stepwise regression techniques using $F$ test well Akaike information criterion systematically determine predictive variables...

Listening to speech in noise is effortful for individuals with hearing loss, even if they have received a prosthesis such as aid or cochlear implant (CI). At present, little known about the neural functions that support listening effort. One form of activity has been suggested reflect effort power 8–12 Hz (alpha) oscillations measured by electroencephalography (EEG). Alpha two cortical regions associated listening—left inferior frontal gyrus (IFG), and parietal cortex—but these relationships...

Abstract Objectives/Hypothesis: Cochlear implantation is now the standard of care in patients with significant sensorineural hearing loss. It well known that severe loss also experience disabling tinnitus. The purpose this study was to assess effects cochlear implants on perception tinnitus using Tinnitus Handicap Inventory (THI). Study Design: Prospective, longitudinal 142 implant patients. Methods: THI administered pre‐ and postimplantation. Outcome measures were obtained 12 months after...

Controversy still exists regarding the impact of age on speech recognition following cochlear implant in postlingually deaf adults. In some studies elderly recipients did not perform as well younger patients standard tests. Furthermore, previous have shown that implantation improves quality life, measured by self-administered questionnaires, but sample sizes these been relatively small, thus making stratification a challenge.The primary objective was to assess whether at which patient...

Cochlear implantation has become a mainstream treatment option for patients with severe to profound sensorineural hearing loss. During cochlear implant, there are key surgical steps which influenced by anatomical variations between each patient. The aim of this study is determine if potential predictors difficulties that may be encountered during the cortical mastoidectomy, facial recess approach and round window access in implant surgery based upon pre-operative temporal bone CT scan.Fifty...

Background In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of cochlear duct, polarized orientation stereociliary bundles, differentiation periotic mesenchyme, and homeostasis stria vascularis. neonatal tissue can drive proliferation cells in sensory region, suggesting that could be used to regenerate epithelium damaged adult ear. Manipulation regeneration will require an understanding dynamics pathway gene expression We present a comprehensive...

The microRNA (miR)-183/96/182 cluster plays important roles in the development and functions of sensory organs, including inner ear. Point-mutations seed sequence miR-96 result non-syndromic hearing loss both mice humans. However, lack a functionally null mutant has hampered evaluation cluster's physiological functions. Here we have characterized loss-of-function mouse model (miR-183CGT/GT), which miR-183/96/182 gene is inactivated by gene-trap (GT) construct. homozygous show profound...

Objectives: To predict postoperative cochlear implant performance with heterogeneous text and numerical variables using supervised machine learning techniques. Study Design: A approach comprising neural networks decision tree-based ensemble algorithms were used to 1-year based on retrospective data. Setting: Tertiary referral center. Patients: One thousand six hundred four adults who received one from 1989 2019. Two eighty two objective demographic, audiometric, patient-reported outcome...

Hearing preservation (HP) in the context of cochlear implantation (CI) is indicative an atraumatic insertion, which could potentially offer a clinical advantage to performance, whether such was intended for application electoacoustic stimulation (EAS). Our goal determine degree HP after full-length electrode array (MedEl FLEXsoft).Prospective, within-subject repeated measure design.Adult patients with residual low-frequency hearing who received 31.5-mm FlexSoft were included. Implantation...

To investigate the effects of unilateral multi-channel cochlear implant surgery on health-related quality life and to determine if there is an age-related impact implantation these effects.Prospective study.Tertiary health-care center.The Short Form-36 survey (SF-36) was administered 283 age-stratified patients before after surgery.Precochlear postcochlear changes in as determined by SF-36 questionnaire.There were significant increases precochlear scores for 5 8 domains: vitality, physical...

To evaluate whether the depth of cochlear implant array within cochlea affects performance outcomes 1 year following implantation.A retrospective case review 120 patients who were implanted with Advanced Bionics HiFocus 1J. Post-implantation plain-radiographs retrospectively reviewed, and insertion was measured in degrees from round window to electrode tip. Correlation between 1-year post-activation Hearing Noise Test (HINT) scores analyzed. Intrascala position not assessed.Depth ranged 180°...

Moderate noise exposure may cause acute loss of cochlear synapses without affecting the hair cells and hearing threshold; thus, it remains "hidden" to standard clinical tests. This synaptopathy is one main pathologies noise-induced (NIHL). There no effective treatment for NIHL, mainly because lack a proper drug-delivery technique. We hypothesized that local magnetic delivery gene therapy into inner ear could be beneficial NIHL. In this study, we used superparamagnetic iron oxide...

Abstract Objectives/Hypothesis: Evaluate the characteristics and outcomes of patients with autoimmune inner ear disease (AIED) who have undergone cochlear implantation (CI) compare post‐CI performance in AIED to matched controls. Study Design: Retrospective case control study. Methods: cohort was comprised 25 adult implantees (AIED [n = 18], Cogan syndrome 7]). The group defined by rapidly progressive bilateral sensorineural hearing loss leading unusable within weeks months. Patients...

Ménière's disease (MD) that results in bilateral severe to profound sensorineural hearing loss is a rare indication for cochlear implantation; only few studies exist documenting performance these patients. The primary objective was compare the difference preoperative 12-month postoperative speech perception scores among subjects with MD and controls. Groupwise comparisons of secondary outcomes (Tinnitus Handicap Inventory [THI] scores, 36-Item Short Form [SF-36] dizziness) were also...

Objective To investigate glucocorticoid uptake in auditory hair cells following transtympanic versus systemic administration of dexamethasone. Study design Controlled experimental study. Setting Translational science laboratory. Methods Swiss-Webster mice were injected with dexamethasone via or administration. At 1, 6, 12 hours post-injection the temporal bones harvested. After cryosectioning, immunohistochemical staining was performed using an antibody for Results Dexamethasone labelling...